| 1 | Thu Nov 7 | vs Kennesaw St | W86-55 | 1-0 | 1.000 | - | | The Knapp Center · Des Moines, IA |
| 2 | Mon Nov 11 | at Cincinnati | L59-81 | 1-1 | .500 | - | | Fifth Third Arena · Cincinnati, OH |
| 3 | Wed Nov 13 | vs Kansas City | W76-58 | 2-1 | .667 | - | | The Knapp Center · Des Moines, IA |
| 4 | Sun Nov 17 | vs TBD | W98-53 | 3-1 | .750 | - | | The Knapp Center · Des Moines, IA |
| 5 | Thu Nov 21 | vs Lehigh | W74-58 | 4-1 | .800 | - | | The Knapp Center · Des Moines, IA |
| 6 | Mon Nov 25 | vs Miami OH | L59-67 | 4-2 | .667 | - | | The Knapp Center · Des Moines, IA |
| 7 | Tue Nov 26 | at Northeastern | W59-56 | 5-2 | .714 | - | | Matthews Arena · Boston, MA |
| 8 | Wed Nov 27 | vs Murray St | W63-53 | 6-2 | .750 | - | | The Knapp Center · Des Moines, IA |
| 9 | Tue Dec 3 | vs Milwaukee | W56-53 | 7-2 | .778 | - | | The Knapp Center · Des Moines, IA |
| 10 | Sat Dec 7 | vs SE Missouri St | W78-73 | 8-2 | .800 | - | | The Knapp Center · Des Moines, IA |
| 11 | Sat Dec 14 | at #14Dayton | L47-78 | 8-3 | .727 | - | | UD Arena · Dayton, OH |
| 12 | Tue Dec 17 | vsTBD | W92-74 | 9-3 | .750 | - | | The Knapp Center · Des Moines, IA |
| 13 | Sat Dec 21 | at Air Force | W85-80 | 10-3 | .769 | - | | Clune Arena · Colorado Springs, CO |
| 14 | Tue Dec 31 | at Bradley | L72-80 | 10-4 | .714 | - | | Carver Arena · Peoria, IL |
| 15 | Sat Jan 4 | vs Indiana St | W80-76 | 11-4 | .733 | - | | The Knapp Center · Des Moines, IA |
| 16 | Tue Jan 7 | vs Loyola Chicago | W65-62 | 12-4 | .750 | - | CBS | The Knapp Center · Des Moines, IA |
| 17 | Sat Jan 11 | at Valparaiso | L61-66 | 12-5 | .706 | - | | Athletics-Recreation Center · Valparaiso, IN |
| 18 | Thu Jan 16 | vs Illinois St | W84-74 | 13-5 | .722 | - | | The Knapp Center · Des Moines, IA |
| 19 | Sun Jan 19 | at S Illinois | L49-66 | 13-6 | .684 | - | | Banterra Center · Carbondale, IL |
| 20 | Wed Jan 22 | at Evansville | W73-50 | 14-6 | .700 | - | | Ford Center · Evansville, IN |
| 21 | Sun Jan 26 | vs Missouri St | W71-69 | 15-6 | .714 | - | | The Knapp Center · Des Moines, IA |
| 22 | Wed Jan 29 | atIndiana St | L56-58 | 15-7 | .682 | - | | Hulman Center · Terre Haute, IN |
| 23 | Sat Feb 1 | vsS Illinois | L72-79 | 15-8 | .652 | - | | The Knapp Center · Des Moines, IA |
| 24 | Wed Feb 5 | vsBradley | W73-60 | 16-8 | .667 | - | | The Knapp Center · Des Moines, IA |
| 25 | Sat Feb 8 | at Northern Iowa | L73-83 | 16-9 | .640 | - | | McLeod Center · Cedar Falls, IA |
| 26 | Wed Feb 12 | atMissouri St | L62-97 | 16-10 | .615 | - | | Great Southern Bank Arena · Springfield, MO |
| 27 | Sun Feb 16 | vsEvansville | W85-80 | 17-10 | .630 | - | | The Knapp Center · Des Moines, IA |
| 28 | Wed Feb 19 | vsValparaiso | W77-75 (OT) | 18-10 | .643 | - | | The Knapp Center · Des Moines, IA |
| 29 | Sat Feb 22 | atIllinois St | L53-57 | 18-11 | .621 | - | | Redbird Arena · Normal, IL |
| 30 | Tue Feb 25 | atLoyola Chicago | L60-64 | 18-12 | .600 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 31 | Sat Feb 29 | vsNorthern Iowa | L43-70 | 18-13 | .581 | - | ESPN2 | The Knapp Center · Des Moines, IA |
| 32 | Thu Mar 5 | vsIllinois St | W75-65 | 19-13 | .594 | - | | The Knapp Center · Des Moines, IA |
| 33 | Fri Mar 6 | atNorthern Iowa | W77-56 | 20-13 | .606 | - | | McLeod Center · Cedar Falls, IA |
| 34 | Sat Mar 7 | atBradley | L66-76 | 20-14 | .588 | - | CBS | Carver Arena · Peoria, IL |
