| 1 | Tue Nov 9 | vs TBD | W87-61 | 1-0 | 1.000 | - | | The Knapp Center · Des Moines, IA |
| 2 | Sun Nov 14 | vs South Dakota | W99-50 | 2-0 | 1.000 | - | | The Knapp Center · Des Moines, IA |
| 3 | Sat Nov 20 | vs Richmond | W73-70 | 3-0 | 1.000 | - | | The Knapp Center · Des Moines, IA |
| 4 | Thu Nov 25 | vs Belmont | L69-74 | 3-1 | .750 | - | ESPNU | The Knapp Center · Des Moines, IA |
| 5 | Fri Nov 26 | vs Alabama | L71-80 | 3-2 | .600 | - | ESPNU | The Knapp Center · Des Moines, IA |
| 6 | Sun Nov 28 | vs North Texas | L54-57 | 3-3 | .500 | - | ESPNU | The Knapp Center · Des Moines, IA |
| 7 | Thu Dec 2 | vs Valparaiso | W73-66 | 4-3 | .571 | - | ESPNU | The Knapp Center · Des Moines, IA |
| 8 | Sun Dec 5 | vs St Thomas (MN) | W74-64 | 5-3 | .625 | - | | The Knapp Center · Des Moines, IA |
| 9 | Wed Dec 8 | at Omaha | W78-70 | 6-3 | .667 | - | | Baxter Arena · Omaha, NE |
| 10 | Sat Dec 11 | at Clemson | L80-90 (OT) | 6-4 | .600 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 11 | Thu Dec 16 | vs Jackson St | W70-65 (OT) | 7-4 | .636 | - | | The Knapp Center · Des Moines, IA |
| 12 | Sun Dec 19 | vs UT Martin | W80-54 | 8-4 | .667 | - | | The Knapp Center · Des Moines, IA |
| 13 | Wed Dec 22 | vs Chicago St | W87-50 | 9-4 | .692 | - | | The Knapp Center · Des Moines, IA |
| 14 | Tue Dec 28 | vsTBD | W82-53 | 10-4 | .714 | - | | The Knapp Center · Des Moines, IA |
| 15 | Sun Jan 2 | at Missouri St | L56-61 | 10-5 | .667 | - | | Great Southern Bank Arena · Springfield, MO |
| 16 | Wed Jan 5 | at S Illinois | PPD | 25-11 | .694 | - | | Banterra Center · Carbondale, IL |
| 17 | Sat Jan 8 | at Evansville | W60-59 | 11-5 | .688 | - | | Ford Center · Evansville, IN |
| 18 | Wed Jan 12 | vs Illinois St | W86-75 | 12-5 | .706 | - | | The Knapp Center · Des Moines, IA |
| 19 | Mon Jan 17 | atS Illinois | W60-59 | 13-5 | .722 | - | | Banterra Center · Carbondale, IL |
| 20 | Wed Jan 19 | vs Bradley | L71-83 | 13-6 | .684 | - | | The Knapp Center · Des Moines, IA |
| 21 | Sat Jan 22 | at Northern Iowa | W82-74 (OT) | 14-6 | .700 | - | ESPNU | McLeod Center · Cedar Falls, IA |
| 22 | Wed Jan 26 | atIllinois St | W89-88 (OT) | 15-6 | .714 | - | | Redbird Arena · Normal, IL |
| 23 | Sun Jan 30 | vs Loyola Chicago | W77-68 | 16-6 | .727 | - | ESPN2 | The Knapp Center · Des Moines, IA |
| 24 | Wed Feb 2 | at Indiana St | W85-67 | 17-6 | .739 | - | | Hulman Center · Terre Haute, IN |
| 25 | Sat Feb 5 | vsNorthern Iowa | L69-74 (OT) | 17-7 | .708 | - | ESPNU | The Knapp Center · Des Moines, IA |
| 26 | Wed Feb 9 | vsMissouri St | L62-66 | 17-8 | .680 | - | | The Knapp Center · Des Moines, IA |
| 27 | Sat Feb 12 | atBradley | L59-68 | 17-9 | .654 | - | | Carver Arena · Peoria, IL |
| 28 | Wed Feb 16 | vsEvansville | W73-51 | 18-9 | .667 | - | | The Knapp Center · Des Moines, IA |
| 29 | Sat Feb 19 | atLoyola Chicago | W83-76 | 19-9 | .679 | - | ESPN2 | Joseph J. Gentile Arena · Chicago, IL |
| 30 | Mon Feb 21 | vsIndiana St | W74-58 | 20-9 | .690 | - | | The Knapp Center · Des Moines, IA |
| 31 | Wed Feb 23 | atValparaiso | W71-65 | 21-9 | .700 | - | | Athletics-Recreation Center · Valparaiso, IN |
| 32 | Sat Feb 26 | vsS Illinois | W62-60 | 22-9 | .710 | - | CBS | The Knapp Center · Des Moines, IA |
| 33 | Fri Mar 4 | vsS Illinois | W65-52 | 23-9 | .719 | - | | The Knapp Center · Des Moines, IA |
| 34 | Sat Mar 5 | atMissouri St | W79-78 (OT) | 24-9 | .727 | - | CBS | Great Southern Bank Arena · Springfield, MO |
| 35 | Sun Mar 6 | vsLoyola Chicago | L58-64 | 24-10 | .706 | - | CBS | The Knapp Center · Des Moines, IA |
| 36 | Sat Mar 19 | at Purdue FW | W87-65 | 25-10 | .714 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 37 | Mon Mar 21 | at UNC Wilmington | L75-76 | 25-11 | .694 | - | | Trask Coliseum · Wilmington, NC |
