| 3 | Mon Nov 10 | vs Lindenwood | 8:00 PM | 1-1 | .500 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 4 | Sat Nov 15 | vsGrand Canyon | 8:00 PM | 1-1 | .500 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 5 | Fri Nov 21 | vsPurdue FW | 8:00 PM | 0-2 | .000 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 6 | Thu Nov 27 | vsSanta Clara | 7:00 PM | 2-0 | 1.000 | - | | Chaifetz Arena · St. Louis, MO |
| 7 | Tue Dec 2 | atLMU | 10:00 PM | 2-0 | 1.000 | - | ESPN+ | Gersten Pavilion · Los Angeles, CA |
| 8 | Sun Dec 7 | vsC Michigan | 3:00 PM | 1-0 | 1.000 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 9 | Sat Dec 13 | vsSan Francisco | 8:00 PM | 1-0 | 1.000 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 10 | Wed Dec 17 | vsBethune | 8:00 PM | 0-2 | .000 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 11 | Sun Dec 21 | vsNew Hampshire | 3:00 PM | 1-1 | .500 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 12 | Sun Dec 28 | vsTBD | 3:00 PM | 0-0 | .000 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 13 | Wed Dec 31 | vsSaint Joseph's | 4:00 PM | 1-0 | 1.000 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 14 | Wed Jan 7 | atVCU | 7:00 PM | 1-1 | .500 | - | | Stuart C. Siegel Center · Richmond, VA |
| 15 | Sat Jan 10 | atLa Salle | 4:00 PM | 1-0 | 1.000 | - | | Tom Gola Arena · Philadelphia, PA |
| 16 | Wed Jan 14 | vsFordham | 8:00 PM | 1-1 | .500 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 17 | Sat Jan 17 | vsRichmond | 4:00 PM | 1-0 | 1.000 | - | | Chaifetz Arena · St. Louis, MO |
| 18 | Tue Jan 20 | atDuquesne | 7:00 PM | 2-0 | 1.000 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 19 | Fri Jan 23 | atSt Bonaventure | 5:30 PM | 1-0 | 1.000 | - | ESPN2 | Reilly Center · Saint Bonaventure, NY |
| 20 | Tue Jan 27 | vsG Washington | 8:00 PM | 1-0 | 1.000 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 21 | Fri Jan 30 | vsDayton | 8:00 PM | 1-0 | 1.000 | - | | Chaifetz Arena · St. Louis, MO |
| 22 | Tue Feb 3 | atDavidson | 9:00 PM | 2-0 | 1.000 | - | | John M. Belk Arena · Davidson, NC |
| 23 | Sat Feb 7 | vsLa Salle | 3:00 PM | 1-0 | 1.000 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 24 | Fri Feb 13 | atLoyola Chicago | 8:30 PM | 1-1 | .500 | - | ESPN2 | Joseph J. Gentile Arena · Chicago, IL |
| 25 | Tue Feb 17 | atRhode Island | 7:00 PM | 1-1 | .500 | - | ESPN+ | Ryan Center · Kingston, RI |
| 26 | Fri Feb 20 | vsVCU | 7:00 PM | 1-1 | .500 | - | ESPN2 | Chaifetz Arena · St. Louis, MO |
| 27 | Tue Feb 24 | atDayton | 7:00 PM | 1-0 | 1.000 | - | ESPN+ | UD Arena · Dayton, OH |
| 28 | Sat Feb 28 | vsDuquesne | 8:00 PM | 2-0 | 1.000 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 29 | Wed Mar 4 | vsLoyola Chicago | 8:00 PM | 1-1 | .500 | - | | Chaifetz Arena · St. Louis, MO |
| 30 | Sat Mar 7 | atGeorge Mason | 4:00 PM | 2-0 | 1.000 | - | | EagleBank Arena · Fairfax, VA |
