| 1 | Mon Nov 3 | vs SE Missouri St | W92-67 | - | 1-0 | 1.000 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 2 | Thu Nov 6 | vsChicago St | W108-86 | - | 2-0 | 1.000 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 3 | Mon Nov 10 | vsLindenwood | W109-66 | - | 3-0 | 1.000 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 4 | Sat Nov 15 | vsGrand Canyon | W78-64 | - | 4-0 | 1.000 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 5 | Fri Nov 21 | vsPurdue FW | W91-60 | - | 5-0 | 1.000 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 6 | Thu Nov 27 | vsSanta Clara | W71-70 | -1½ | 6-0 | 1.000 | - | CBS Sports Network | Chaifetz Arena · St. Louis, MO |
| 7 | Fri Nov 28 | vsStanford | L77-78 | -1½ | 6-1 | .857 | - | truTV | Chaifetz Arena · St. Louis, MO |
| 8 | Tue Dec 2 | atLMU | W91-70 | -7½ | 7-1 | .875 | - | ESPN+ | Gersten Pavilion · Los Angeles, CA |
| 9 | Sun Dec 7 | vsC Michigan | W107-65 | -24½ | 8-1 | .889 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 10 | Sat Dec 13 | vsSan Francisco | W85-75 | -12½ | 9-1 | .900 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 11 | Wed Dec 17 | vsBethune | W112-53 | -26½ | 10-1 | .909 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 12 | Sun Dec 21 | vsNew Hampshire | W93-79 | -34½ | 11-1 | .917 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 13 | Sun Dec 28 | vsTBD | W114-33 | - | 12-1 | .923 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 14 | Wed Dec 31 | vsSaint Joseph's | W102-79 | -19½ | 13-1 | .929 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 15 | Wed Jan 7 | atVCU | W71-62 | +1½ | 14-1 | .933 | - | CBS Sports Network | Stuart C. Siegel Center · Richmond, VA |
| 16 | Sat Jan 10 | atLa Salle | W84-72 | -17½ | 15-1 | .938 | - | USA Network | Tom Gola Arena · Philadelphia, PA |
| 17 | Wed Jan 14 | vsFordham | W78-56 | -17½ | 16-1 | .941 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 18 | Sat Jan 17 | vsRichmond | W88-63 | -14½ | 17-1 | .944 | - | CBS Sports Network | Chaifetz Arena · St. Louis, MO |
| 19 | Tue Jan 20 | atDuquesne | W81-77 | -8½ | 18-1 | .947 | #24 | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 20 | Fri Jan 23 | atSt Bonaventure | W97-62 | -8½ | 19-1 | .950 | #24 | ESPN2 | Reilly Center · Saint Bonaventure, NY |
| 21 | Tue Jan 27 | vsG Washington | W79-76 | -10½ | 20-1 | .952 | #21 | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 22 | Fri Jan 30 | vsDayton | W102-71 | -9½ | 21-1 | .955 | #21 | CBS Sports Network | Chaifetz Arena · St. Louis, MO |
| 23 | Tue Feb 3 | atDavidson | W91-82 | -8½ | 22-1 | .957 | #19 | CBS Sports Network | John M. Belk Arena · Davidson, NC |
| 24 | Sat Feb 7 | vsLa Salle | W82-58 | -22½ | 23-1 | .958 | #19 | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 25 | Fri Feb 13 | atLoyola Chicago | W86-59 | -17½ | 24-1 | .960 | #18 | ESPN2 | Joseph J. Gentile Arena · Chicago, IL |
| 26 | Tue Feb 17 | atRhode Island | L76-81 | -9½ | 24-2 | .923 | #18 | ESPN+ | Ryan Center · Kingston, RI |
| 27 | Fri Feb 20 | vsVCU | W88-75 | -7½ | 25-2 | .926 | #18 | ESPN2 | Chaifetz Arena · St. Louis, MO |
| 28 | Tue Feb 24 | atDayton | L62-77 | -3½ | 25-3 | .893 | #23 | ESPN+ | UD Arena · Dayton, OH |
| 29 | Sat Feb 28 | vsDuquesne | W91-76 | -13½ | 26-3 | .897 | #23 | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 30 | Wed Mar 4 | vsLoyola Chicago | W79-65 | -21½ | 27-3 | .900 | #25 | CBS Sports Network | Chaifetz Arena · St. Louis, MO |
| 31 | Sat Mar 7 | atGeorge Mason | L57-86 | -7½ | 27-4 | .871 | #25 | USA Network | EagleBank Arena · Fairfax, VA |
| 32 | Fri Mar 13 | vsG Washington | W88-81 | -6½ | 28-4 | .875 | - | USA Network | Chaifetz Arena · St. Louis, MO |
| 33 | Sat Mar 14 | vsDayton | L69-70 | -4½ | 28-5 | .848 | - | CBS Sports Network | Chaifetz Arena · St. Louis, MO |
| R1 | Thu Mar 19 | at8Georgia | W102-77 | +1½ | 29-5 | .853 | #9 | CBS | KeyBank Center · Buffalo, NY |
| R2 | Sat Mar 21 | at1Michigan | L72-95 | +12½ | 29-6 | .829 | #9 | CBS | KeyBank Center · Buffalo, NY |
