| 1 | Mon Nov 6 | vs So Indiana | W75-63 | 1-0 | 1.000 | - | | Chaifetz Arena · St. Louis, MO |
| 2 | Wed Nov 8 | vsTBD | W102-66 | 2-0 | 1.000 | - | | Chaifetz Arena · St. Louis, MO |
| 3 | Sat Nov 11 | vsIllinois St | W80-71 | 3-0 | 1.000 | - | | Chaifetz Arena · St. Louis, MO |
| 4 | Thu Nov 16 | atWyoming | W79-69 | 4-0 | 1.000 | - | ESPN2 | The HTC Center · Conway, SC |
| 5 | Fri Nov 17 | vsVermont | L68-78 | 4-1 | .800 | - | ESPN2 | The HTC Center · Conway, SC |
| 6 | Sun Nov 19 | atWichita St | L69-88 | 4-2 | .667 | - | ESPN2 | The HTC Center · Conway, SC |
| 7 | Sat Nov 25 | vsDartmouth | W66-65 | 5-2 | .714 | - | | Chaifetz Arena · St. Louis, MO |
| 8 | Tue Nov 28 | vsUtah State | L76-81 | 5-3 | .625 | - | | Chaifetz Arena · St. Louis, MO |
| 9 | Sat Dec 2 | atS Illinois | L62-101 | 5-4 | .556 | - | | Banterra Center · Carbondale, IL |
| 10 | Wed Dec 6 | atDrake | L69-75 | 5-5 | .500 | - | | The Knapp Center · Des Moines, IA |
| 11 | Sat Dec 9 | vsHofstra | W71-68 | 6-5 | .545 | - | | Chaifetz Arena · St. Louis, MO |
| 12 | Sat Dec 16 | vsLouisiana Tech | W75-74 | 7-5 | .583 | - | | Chaifetz Arena · St. Louis, MO |
| 13 | Wed Dec 20 | atNC State | L70-82 | 7-6 | .538 | - | | PNC Arena · Raleigh, NC |
| 14 | Wed Jan 3 | vsLoyola Chicago | L73-80 | 7-7 | .500 | - | | Chaifetz Arena · St. Louis, MO |
| 15 | Sat Jan 6 | atGeorge Mason | L67-79 | 7-8 | .467 | - | USA Net | EagleBank Arena · Fairfax, VA |
| 16 | Wed Jan 10 | vsSaint Joseph's | W88-85 | 8-8 | .500 | - | CBSSN | Chaifetz Arena · St. Louis, MO |
| 17 | Tue Jan 16 | at21Dayton | L65-70 | 8-9 | .471 | - | CBSSN | UD Arena · Dayton, OH |
| 18 | Fri Jan 19 | atVCU | L61-85 | 8-10 | .444 | - | ESPN2 | Stuart C. Siegel Center · Richmond, VA |
| 19 | Wed Jan 24 | vsDavidson | L61-84 | 8-11 | .421 | - | | Chaifetz Arena · St. Louis, MO |
| 20 | Sat Jan 27 | vsUMass | L73-84 | 8-12 | .400 | - | | Chaifetz Arena · St. Louis, MO |
| 21 | Tue Jan 30 | atLoyola Chicago | L62-77 | 8-13 | .381 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 22 | Sat Feb 3 | vsFordham | L65-67 | 8-14 | .364 | - | USA Net | Chaifetz Arena · St. Louis, MO |
| 23 | Wed Feb 7 | atLa Salle | W102-84 | 9-14 | .391 | - | | Tom Gola Arena · Philadelphia, PA |
| 24 | Sat Feb 10 | atSaint Joseph's | L86-87 | 9-15 | .375 | - | USA Net | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 25 | Fri Feb 16 | vsVCU | L85-95 | 9-16 | .360 | - | ESPN2 | Chaifetz Arena · St. Louis, MO |
| 26 | Tue Feb 20 | atDuquesne | L66-81 | 9-17 | .346 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 27 | Sat Feb 24 | vsG Washington | W96-91 | 10-17 | .370 | - | | Chaifetz Arena · St. Louis, MO |
| 28 | Wed Feb 28 | vsRichmond | L64-80 | 10-18 | .357 | - | | Chaifetz Arena · St. Louis, MO |
| 29 | Sat Mar 2 | atRhode Island | W94-91 | 11-18 | .379 | - | CBSSN | Ryan Center · Kingston, RI |
| 30 | Tue Mar 5 | vs25Dayton | L83-100 | 11-19 | .367 | - | CBSSN | Chaifetz Arena · St. Louis, MO |
| 31 | Sat Mar 9 | atSt Bonaventure | W73-65 | 12-19 | .387 | - | USA Net | Reilly Center · Saint Bonaventure, NY |
| 32 | Tue Mar 12 | atRhode Island | W74-71 | 13-19 | .406 | - | | Ryan Center · Kingston, RI |
| 33 | Wed Mar 13 | atDuquesne | L73-83 | 13-20 | .394 | - | USA Net | UPMC Cooper Fieldhouse · Pittsburgh, PA |
