| 1 | Tue Nov 5 | vs FGCU | W89-67 | 1-0 | 1.000 | - | | Chaifetz Arena · St. Louis, MO |
| 2 | Sat Nov 9 | vs Valparaiso | W81-70 | 2-0 | 1.000 | - | | Chaifetz Arena · St. Louis, MO |
| 3 | Wed Nov 13 | vs E Washington | W82-60 | 3-0 | 1.000 | - | | Chaifetz Arena · St. Louis, MO |
| 4 | Sun Nov 17 | vs #12Seton Hall | L66-83 | 3-1 | .750 | - | ESPNU | Chaifetz Arena · St. Louis, MO |
| 5 | Wed Nov 20 | vs High Point | W67-55 | 4-1 | .800 | - | | Chaifetz Arena · St. Louis, MO |
| 6 | Sat Nov 23 | vs Belmont | W60-55 | 5-1 | .833 | - | | Chaifetz Arena · St. Louis, MO |
| 7 | Wed Nov 27 | at Boston College | W64-54 | 6-1 | .857 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 8 | Sun Dec 1 | vs S Illinois | W69-60 | 7-1 | .875 | - | | Chaifetz Arena · St. Louis, MO |
| 9 | Sun Dec 8 | at Tulane | W86-62 | 8-1 | .889 | - | | Devlin Fieldhouse · New Orleans, LA |
| 10 | Sat Dec 14 | at Auburn | L61-67 | 8-2 | .800 | - | ESPN2 | Neville Arena · Auburn, AL |
| 11 | Tue Dec 17 | vs TBD | W82-69 | 9-2 | .818 | - | | Chaifetz Arena · St. Louis, MO |
| 12 | Sat Dec 21 | at Kansas St | W66-63 | 10-2 | .833 | - | | Bramlage Coliseum · Manhattan, KS |
| 13 | Sun Dec 29 | vs Bethune | W77-67 | 11-2 | .846 | - | | Chaifetz Arena · St. Louis, MO |
| 14 | Thu Jan 2 | at Duquesne | L59-73 | 11-3 | .786 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 15 | Sun Jan 5 | vs UMass | W83-80 (OT) | 12-3 | .800 | - | NBCSN | Chaifetz Arena · St. Louis, MO |
| 16 | Wed Jan 8 | vs G Washington | W63-58 | 13-3 | .813 | - | | Chaifetz Arena · St. Louis, MO |
| 17 | Sat Jan 11 | at Richmond | W74-58 | 14-3 | .824 | - | | Robins Center · Richmond, VA |
| 18 | Fri Jan 17 | vs #13Dayton | L76-78 (OT) | 14-4 | .778 | - | ESPN2 | Chaifetz Arena · St. Louis, MO |
| 19 | Wed Jan 22 | at Davidson | L59-71 | 14-5 | .737 | - | | John M. Belk Arena · Davidson, NC |
| 20 | Sun Jan 26 | vs Fordham | W55-39 | 15-5 | .750 | - | | Chaifetz Arena · St. Louis, MO |
| 21 | Wed Jan 29 | at La Salle | W77-76 (OT) | 16-5 | .762 | - | | Tom Gola Arena · Philadelphia, PA |
| 22 | Sat Feb 1 | at Saint Joseph's | W78-73 | 17-5 | .773 | - | NBCSN | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 23 | Wed Feb 5 | vsDuquesne | L68-82 | 17-6 | .739 | - | | Chaifetz Arena · St. Louis, MO |
| 24 | Sat Feb 8 | at#6Dayton | L65-71 | 17-7 | .708 | - | CBS | UD Arena · Dayton, OH |
| 25 | Sat Feb 15 | vsLa Salle | W84-69 | 18-7 | .720 | - | NBCSN | Chaifetz Arena · St. Louis, MO |
| 26 | Tue Feb 18 | atUMass | L63-67 | 18-8 | .692 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 27 | Fri Feb 21 | vs VCU | W80-62 | 19-8 | .704 | - | ESPN2 | Chaifetz Arena · St. Louis, MO |
| 28 | Wed Feb 26 | vsSaint Joseph's | W76-63 | 20-8 | .714 | - | CBS | Chaifetz Arena · St. Louis, MO |
| 29 | Sun Mar 1 | at Rhode Island | W72-62 | 21-8 | .724 | - | ESPNU | Ryan Center · Kingston, RI |
| 30 | Wed Mar 4 | at George Mason | W69-57 | 22-8 | .733 | - | | EagleBank Arena · Fairfax, VA |
| 31 | Sat Mar 7 | vs St Bonaventure | W72-49 | 23-8 | .742 | - | | Chaifetz Arena · St. Louis, MO |
