| 1 | Mon Nov 4 | at Santa Clara | L78-85 | - | 0-1 | .000 | - | | Leavey Center · Santa Clara, CA |
| 2 | Sun Nov 10 | vsTBD | W95-44 | - | 1-1 | .500 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 3 | Sat Nov 16 | vsLMU | W77-71 | - | 2-1 | .667 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 4 | Fri Nov 22 | vsWichita St | L63-88 | - | 2-2 | .500 | - | Peacock | T-Mobile Center · Kansas City, MOS |
| 5 | Mon Nov 25 | vsQuinnipiac | W81-67 | - | 3-2 | .600 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 6 | Wed Nov 27 | vsUMass Lowell | W93-90 | - | 4-2 | .667 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 7 | Mon Dec 2 | vsJackson St | W74-66 | - | 5-2 | .714 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 8 | Thu Dec 5 | atSan Francisco | L61-78 | - | 5-3 | .625 | - | ESPN+ | War Memorial at the Sobrato Center · San Francisco, CA |
| 9 | Sun Dec 8 | vsChicago St | W85-62 | - | 6-3 | .667 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 10 | Sun Dec 15 | atIllinois St | L77-81 | - | 6-4 | .600 | - | ESPN+ | Redbird Arena · Normal, IL |
| 11 | Wed Dec 18 | vsWofford | L71-74 | - | 6-5 | .545 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 12 | Sun Dec 22 | atGrand Canyon | L72-73 | - | 6-6 | .500 | - | ESPN+ | GCU Arena · Phoenix, AZ |
| 13 | Sat Dec 28 | vsTBD | W78-57 | - | 7-6 | .538 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 14 | Tue Dec 31 | atFordham | W88-63 | - | 8-6 | .571 | - | ESPN+ | Rose Hill Gymnasium · Bronx, NY |
| 15 | Fri Jan 3 | vsSaint Joseph's | W73-57 | - | 9-6 | .600 | - | ESPN2 | Chaifetz Arena · St. Louis, MO |
| 16 | Wed Jan 8 | vsSt Bonaventure | W73-68 | - | 10-6 | .625 | - | Peacock | Chaifetz Arena · St. Louis, MO |
| 17 | Tue Jan 14 | atVCU | L62-78 | - | 10-7 | .588 | - | ESPN+ | Stuart C. Siegel Center · Richmond, VA |
| 18 | Sat Jan 18 | atRichmond | W63-59 | - | 11-7 | .611 | - | USA Network | Robins Center · Richmond, VA |
| 19 | Wed Jan 22 | vsLa Salle | W64-52 | - | 12-7 | .632 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 20 | Sat Jan 25 | atG Washington | L61-67 | - | 12-8 | .600 | - | ESPN+ | Charles E. Smith Center · Washington, D.C. |
| 21 | Tue Jan 28 | vsVCU | W78-69 | - | 13-8 | .619 | - | CBS Sports Network | Chaifetz Arena · St. Louis, MO |
| 22 | Fri Jan 31 | vsDayton | L63-71 | - | 13-9 | .591 | - | ESPN2 | Chaifetz Arena · St. Louis, MO |
| 23 | Tue Feb 4 | atUMass | W73-71 | - | 14-9 | .609 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 24 | Fri Feb 7 | atSaint Joseph's | L63-76 | - | 14-10 | .583 | - | ESPNU | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 25 | Tue Feb 11 | vsGeorge Mason | L74-76 (OT) | - | 14-11 | .560 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 26 | Fri Feb 14 | atLoyola Chicago | L69-78 | - | 14-12 | .538 | - | ESPN2 | Joseph J. Gentile Arena · Chicago, IL |
| 27 | Sat Feb 22 | vsRhode Island | W81-66 | - | 15-12 | .556 | - | USA Network | Chaifetz Arena · St. Louis, MO |
| 28 | Tue Feb 25 | atDavidson | W57-56 | - | 16-12 | .571 | - | ESPN+ | John M. Belk Arena · Davidson, NC |
| 29 | Sat Mar 1 | vsLoyola Chicago | W98-67 | - | 17-12 | .586 | - | CBS Sports Network | Chaifetz Arena · St. Louis, MO |
| 30 | Tue Mar 4 | atDayton | L67-75 | - | 17-13 | .567 | - | ESPN+ | UD Arena · Dayton, OH |
| 31 | Sat Mar 8 | vsDuquesne | W90-88 (OT) | - | 18-13 | .581 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 32 | Thu Mar 13 | vsDavidson | W83-75 | - | 19-13 | .594 | - | USA Network | Capital One Arena · Washington, D.C. |
| 33 | Fri Mar 14 | atLoyola Chicago | L64-72 | - | 19-14 | .576 | - | USA Network | Capital One Arena · Washington, D.C. |
| 34 | Tue Mar 18 | atArkansas St | L78-103 | - | 19-15 | .559 | - | ESPNU | First National Bank Arena · Jonesboro, AR |
