| 1 | Mon Nov 6 | vs SIUE | W63-47 | 1-0 | 1.000 | - | | UD Arena · Dayton, OH |
| 2 | Fri Nov 10 | atNorthwestern | L66-71 | 1-1 | .500 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 3 | Thu Nov 16 | atLSU | W70-67 | 2-1 | .667 | - | ESPN2 | Pete Maravich Assembly Center · Baton Rouge, LA |
| 4 | Fri Nov 17 | vsSt John's | W88-81 | 3-1 | .750 | - | ESPN2 | UD Arena · Dayton, OH |
| 5 | Sun Nov 19 | at#6Houston | L55-69 | 3-2 | .600 | - | ESPN | Fertitta Center · Houston, TX |
| 6 | Fri Nov 24 | vsYoungstown St | W77-69 | 4-2 | .667 | - | | UD Arena · Dayton, OH |
| 7 | Wed Nov 29 | atSMU | W65-63 | 5-2 | .714 | - | | Moody Coliseum · Dallas, TX |
| 8 | Sat Dec 2 | vsGrambling | W76-46 | 6-2 | .750 | - | | UD Arena · Dayton, OH |
| 10 | Sat Dec 9 | vsTroy | W82-70 | 7-2 | .778 | - | USA Net | UD Arena · Dayton, OH |
| 11 | Sat Dec 16 | atCincinnati | W82-68 | 8-2 | .800 | - | | Fifth Third Arena · Cincinnati, OH |
| 12 | Wed Dec 20 | vsOakland | W91-67 | 9-2 | .818 | - | | UD Arena · Dayton, OH |
| 13 | Sat Dec 30 | vsLongwood | W78-69 | 10-2 | .833 | - | | UD Arena · Dayton, OH |
| 14 | Wed Jan 3 | atDavidson | W72-59 | 11-2 | .846 | - | CBS | John M. Belk Arena · Davidson, NC |
| 15 | Sun Jan 7 | vsUMass | W64-60 | 12-2 | .857 | - | ESPN2 | UD Arena · Dayton, OH |
| 16 | Fri Jan 12 | atDuquesne | W72-62 | 13-2 | .867 | - | ESPN2 | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 17 | Tue Jan 16 | vsSaint Louis | W70-65 | 14-2 | .875 | #21 | CBS | UD Arena · Dayton, OH |
| 18 | Sat Jan 20 | vsRhode Island | W96-62 | 15-2 | .882 | #21 | USA Net | UD Arena · Dayton, OH |
| 19 | Tue Jan 23 | atLa Salle | W66-54 | 16-2 | .889 | #16 | | Tom Gola Arena · Philadelphia, PA |
| 20 | Sat Jan 27 | atRichmond | L64-69 | 16-3 | .842 | #16 | CBS | Robins Center · Richmond, VA |
| 21 | Tue Jan 30 | vsG Washington | W83-61 | 17-3 | .850 | #21 | | UD Arena · Dayton, OH |
| 22 | Fri Feb 2 | vsSt Bonaventure | W76-71 | 18-3 | .857 | #21 | ESPN2 | UD Arena · Dayton, OH |
| 23 | Tue Feb 6 | atSaint Joseph's | W94-79 | 19-3 | .864 | #18 | CBS | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 24 | Fri Feb 9 | atVCU | L47-49 | 19-4 | .826 | #18 | ESPN2 | Stuart C. Siegel Center · Richmond, VA |
| 25 | Tue Feb 13 | vsDuquesne | W75-59 | 20-4 | .833 | #16 | | UD Arena · Dayton, OH |
| 26 | Sat Feb 17 | vsFordham | W78-70 | 21-4 | .840 | #16 | CBS | UD Arena · Dayton, OH |
| 27 | Wed Feb 21 | atGeorge Mason | L67-71 | 21-5 | .808 | #16 | | EagleBank Arena · Fairfax, VA |
| 28 | Tue Feb 27 | vsDavidson | W80-66 | 22-5 | .815 | #21 | CBS | UD Arena · Dayton, OH |
| 29 | Fri Mar 1 | atLoyola Chicago | L72-77 | 22-6 | .786 | #21 | ESPN2 | Joseph J. Gentile Arena · Chicago, IL |
| 30 | Tue Mar 5 | atSaint Louis | W100-83 | 23-6 | .793 | #25 | CBS | Chaifetz Arena · St. Louis, MO |
| 31 | Fri Mar 8 | vsVCU | W91-86 (OT) | 24-6 | .800 | #25 | ESPN2 | UD Arena · Dayton, OH |
| 32 | Thu Mar 14 | vsDuquesne | L57-65 | 24-7 | .774 | #24 | USA Net | UD Arena · Dayton, OH |
| 33 | Thu Mar 21 | vs#10Nevada | W63-60 | 25-7 | .781 | #7 | TBS | UD Arena · Dayton, OH |
| 34 | Sat Mar 23 | at#2Arizona | L68-78 | 25-8 | .758 | #7 | CBS | McKale Center · Tucson, AZ |
