| 1 | Tue Dec 1 | vs E Illinois | W66-63 | 1-0 | 1.000 | - | | UD Arena · Dayton, OH |
| 2 | Sat Dec 5 | vsSMU | L64-66 | 1-1 | .500 | - | | UD Arena · Dayton, OH |
| 3 | Tue Dec 8 | vsN Kentucky | W66-60 | 2-1 | .667 | - | | UD Arena · Dayton, OH |
| 4 | Sat Dec 12 | vsMississippi St | W85-82 (2OT) | 3-1 | .750 | - | ESPNU | State Farm Arena · Atlanta, GA |
| 5 | Sat Dec 19 | vsOle Miss | W65-62 | 4-1 | .800 | - | NBCSN | UD Arena · Dayton, OH |
| 6 | Wed Dec 30 | vsLa Salle | L65-67 | 4-2 | .667 | - | | UD Arena · Dayton, OH |
| 7 | Sat Jan 2 | vsGeorge Mason | W74-65 | 5-2 | .714 | - | NBCSN | UD Arena · Dayton, OH |
| 8 | Tue Jan 5 | atFordham | L54-55 | 5-3 | .625 | - | | Rose Hill Gymnasium · Bronx, NY |
| 9 | Fri Jan 8 | atDavidson | W89-78 (OT) | 6-3 | .667 | - | ESPN2 | John M. Belk Arena · Davidson, NC |
| 10 | Wed Jan 13 | vsDuquesne | W72-63 | 7-3 | .700 | - | CBSSN | UD Arena · Dayton, OH |
| 11 | Sun Jan 17 | atG Washington | W67-54 | 8-3 | .727 | - | NBCSN | Charles E. Smith Center · Washington, D.C. |
| 13 | Sat Jan 23 | atVCU | L43-66 | 8-4 | .667 | - | CBSSN | Stuart C. Siegel Center · Richmond, VA |
| 14 | Tue Jan 26 | at22Saint Louis | W76-71 | 9-4 | .692 | - | CBSSN | Chaifetz Arena · St. Louis, MO |
| 15 | Sat Jan 30 | vsRhode Island | W67-56 | 10-4 | .714 | - | CBSSN | UD Arena · Dayton, OH |
| 16 | Tue Feb 2 | atDuquesne | L64-69 | 10-5 | .667 | - | ESPN2 | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 17 | Fri Feb 5 | vsGeorge Mason | W74-65 | 11-5 | .688 | - | ESPN2 | UD Arena · Dayton, OH |
| 18 | Tue Feb 9 | vsVCU | L67-76 | 11-6 | .647 | - | | UD Arena · Dayton, OH |
| 20 | Tue Feb 16 | atRhode Island | L89-91 (2OT) | 11-7 | .611 | - | CBSSN | Ryan Center · Kingston, RI |
| 21 | Fri Feb 19 | vsSaint Louis | W76-53 | 12-7 | .632 | - | ESPN2 | UD Arena · Dayton, OH |
| 22 | Wed Feb 24 | atSaint Joseph's | L84-97 | 12-8 | .600 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 23 | Mon Mar 1 | atSt Bonaventure | W55-52 | 13-8 | .619 | - | ESPNU | Reilly Center · Saint Bonaventure, NY |
| 24 | Thu Mar 4 | vsRhode Island | W84-72 | 14-8 | .636 | - | NBCSN | Stuart C. Siegel Center · Richmond, VA |
| 25 | Fri Mar 5 | atVCU | L68-73 | 14-9 | .609 | - | NBCSN | Stuart C. Siegel Center · Richmond, VA |
| 24 | Sat Mar 20 | at1Memphis | L60-71 | 14-10 | .583 | #4 | ESPN | The Super Pit · Denton, TX |
