| 1 | Sat Nov 9 | vs Indiana St | W86-81 | 1-0 | 1.000 | - | | UD Arena · Dayton, OH |
| 2 | Sat Nov 16 | vsCharleston So | W90-61 | 2-0 | 1.000 | - | | UD Arena · Dayton, OH |
| 3 | Tue Nov 19 | vsOmaha | W93-68 | 3-0 | 1.000 | - | | UD Arena · Dayton, OH |
| 4 | Mon Nov 25 | vsGeorgia | W80-61 | 4-0 | 1.000 | - | ESPN2 | UD Arena · Dayton, OH |
| 5 | Tue Nov 26 | atVirginia Tech | W89-62 | 5-0 | 1.000 | - | ESPN | Cassell Coliseum · Blacksburg, VA |
| 6 | Wed Nov 27 | atKansas | L84-90 (OT) | 5-1 | .833 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 7 | Tue Dec 3 | vsHou Christian | W99-68 | 6-1 | .857 | #19 | | UD Arena · Dayton, OH |
| 8 | Sun Dec 8 | atSaint Mary's | W78-68 | 7-1 | .875 | - | ESPNU | University Credit Union Pavilion · Moraga, CA |
| 9 | Sat Dec 14 | vsDrake | W78-47 | 8-1 | .889 | #14 | | UD Arena · Dayton, OH |
| 10 | Tue Dec 17 | vsNorth Texas | W71-58 | 9-1 | .900 | #13 | | UD Arena · Dayton, OH |
| 11 | Sat Dec 21 | atColorado | L76-78 (OT) | 9-2 | .818 | - | CBS | CU Events Center · Boulder, CO |
| 12 | Mon Dec 23 | vsGrambling | W81-53 | 10-2 | .833 | #18 | | UD Arena · Dayton, OH |
| 13 | Mon Dec 30 | vsNorth Florida | W77-59 | 11-2 | .846 | #20 | | UD Arena · Dayton, OH |
| 14 | Thu Jan 2 | atLa Salle | W84-58 | 12-2 | .857 | #20 | CBS | Tom Gola Arena · Philadelphia, PA |
| 15 | Sun Jan 5 | atSaint Joseph's | W80-67 | 13-2 | .867 | #20 | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 16 | Sat Jan 11 | vsUMass | W88-60 | 14-2 | .875 | #15 | NBCSN | UD Arena · Dayton, OH |
| 17 | Tue Jan 14 | vsVCU | W79-65 | 15-2 | .882 | #13 | CBS | UD Arena · Dayton, OH |
| 18 | Fri Jan 17 | atSaint Louis | W78-76 (OT) | 16-2 | .889 | #13 | ESPN2 | Chaifetz Arena · St. Louis, MO |
| 19 | Wed Jan 22 | vsSt Bonaventure | W86-60 | 17-2 | .895 | #7 | CBS | UD Arena · Dayton, OH |
| 20 | Sat Jan 25 | atRichmond | W87-79 | 18-2 | .900 | #7 | | Robins Center · Richmond, VA |
| 21 | Wed Jan 29 | atDuquesne | W73-69 | 19-2 | .905 | #7 | CBS | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 22 | Sat Feb 1 | vsFordham | W70-56 | 20-2 | .909 | #7 | NBCSN | UD Arena · Dayton, OH |
| 23 | Sat Feb 8 | vsSaint Louis | W71-65 | 21-2 | .913 | #6 | CBS | UD Arena · Dayton, OH |
| 24 | Tue Feb 11 | vsRhode Island | W81-67 | 22-2 | .917 | #6 | CBS | UD Arena · Dayton, OH |
| 25 | Sat Feb 15 | atUMass | W71-63 | 23-2 | .920 | #6 | | William D. Mullins Memorial Center · Amherst, MA |
| 26 | Tue Feb 18 | atVCU | W66-61 | 24-2 | .923 | #5 | CBS | Stuart C. Siegel Center · Richmond, VA |
| 27 | Sat Feb 22 | vsDuquesne | W80-70 | 25-2 | .926 | #5 | | UD Arena · Dayton, OH |
| 28 | Tue Feb 25 | atGeorge Mason | W62-55 | 26-2 | .929 | #4 | | EagleBank Arena · Fairfax, VA |
| 29 | Fri Feb 28 | vsDavidson | W82-67 | 27-2 | .931 | #4 | ESPN2 | UD Arena · Dayton, OH |
| 30 | Wed Mar 4 | atRhode Island | W84-57 | 28-2 | .933 | #3 | CBS | Ryan Center · Kingston, RI |
| 31 | Sat Mar 7 | vsG Washington | W76-51 | 29-2 | .935 | #3 | | UD Arena · Dayton, OH |
