| 1 | Sat Nov 9 | vs Iona | W70-64 (OT) | 1-0 | 1.000 | - | NBCSN | Tom Gola Arena · Philadelphia, PA |
| 2 | Wed Nov 13 | atPenn | L59-75 | 1-1 | .500 | - | | The Palestra · Philadelphia, PA |
| 3 | Sat Nov 16 | vsTemple | L65-70 | 1-2 | .333 | - | | Tom Gola Arena · Philadelphia, PA |
| 4 | Mon Nov 25 | atMurray St | W75-64 | 2-2 | .500 | - | | CFSB Center · Murray, KY |
| 5 | Tue Nov 26 | atWright St | W72-70 | 3-2 | .600 | - | | Nutter Center · Dayton, OH |
| 6 | Wed Nov 27 | atSouth Alabama | W81-76 (OT) | 4-2 | .667 | - | | Mitchell Center · Mobile, AL |
| 7 | Sun Dec 1 | at22Villanova | L72-83 | 4-3 | .571 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 8 | Sat Dec 7 | atDrexel | W71-63 | 5-3 | .625 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 9 | Sat Dec 14 | vsMorgan St | W85-68 | 6-3 | .667 | - | | Tom Gola Arena · Philadelphia, PA |
| 10 | Wed Dec 18 | vsWagner | W74-60 | 7-3 | .700 | - | | Tom Gola Arena · Philadelphia, PA |
| 11 | Sat Dec 21 | vsFairleigh | W66-58 | 8-3 | .727 | - | | Tom Gola Arena · Philadelphia, PA |
| 12 | Sat Dec 28 | vsBucknell | W71-59 | 9-3 | .750 | - | | The Palestra · Philadelphia, PA |
| 13 | Thu Jan 2 | vs20Dayton | L58-84 | 9-4 | .692 | - | CBSSN | Tom Gola Arena · Philadelphia, PA |
| 14 | Sun Jan 5 | atFordham | W66-60 | 10-4 | .714 | - | | Rose Hill Gymnasium · Bronx, NY |
| 15 | Wed Jan 8 | atUMass | L69-77 | 10-5 | .667 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 16 | Sat Jan 11 | vsGeorge Mason | L63-76 | 10-6 | .625 | - | | Tom Gola Arena · Philadelphia, PA |
| 17 | Sat Jan 18 | atRhode Island | L63-66 | 10-7 | .588 | - | NBCSN | Ryan Center · Kingston, RI |
| 18 | Wed Jan 22 | atRichmond | L57-75 | 10-8 | .556 | - | | Robins Center · Richmond, VA |
| 19 | Sat Jan 25 | vsVCU | L65-76 | 10-9 | .526 | - | NBCSN | Tom Gola Arena · Philadelphia, PA |
| 20 | Wed Jan 29 | vsSaint Louis | L76-77 (OT) | 10-10 | .500 | - | | Tom Gola Arena · Philadelphia, PA |
| 21 | Sun Feb 2 | atDuquesne | L69-71 | 10-11 | .476 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 22 | Sat Feb 8 | vsSaint Joseph's | W83-66 | 11-11 | .500 | - | NBCSN | Tom Gola Arena · Philadelphia, PA |
| 23 | Wed Feb 12 | vsRichmond | L47-74 | 11-12 | .478 | - | | Tom Gola Arena · Philadelphia, PA |
| 24 | Sat Feb 15 | atSaint Louis | L69-84 | 11-13 | .458 | - | NBCSN | Chaifetz Arena · St. Louis, MO |
| 25 | Wed Feb 19 | vsFordham | W58-49 | 12-13 | .480 | - | | Tom Gola Arena · Philadelphia, PA |
| 26 | Sat Feb 22 | atG Washington | W72-62 | 13-13 | .500 | - | | Charles E. Smith Center · Washington, D.C. |
| 27 | Tue Feb 25 | atDavidson | L49-74 | 13-14 | .481 | - | | John M. Belk Arena · Davidson, NC |
| 28 | Sat Feb 29 | vsSt Bonaventure | W73-65 | 14-14 | .500 | - | | Tom Gola Arena · Philadelphia, PA |
| 29 | Wed Mar 4 | vsUMass | L64-75 | 14-15 | .483 | - | | Tom Gola Arena · Philadelphia, PA |
| 30 | Sat Mar 7 | atSaint Joseph's | W78-77 | 15-15 | .500 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
