| 1 | Thu Nov 26 | at St John's | L65-82 | 0-1 | .000 | - | FS1 | Carnesecca Arena · Queens, NY |
| 2 | Fri Nov 27 | vsSaint Peter's | L51-62 | 0-2 | .000 | - | | Carnesecca Arena · Queens, NY |
| 4 | Sun Dec 6 | atArmy | L59-63 | 0-3 | .000 | - | | Christl Arena · West Point, NY |
| 5 | Tue Dec 8 | vsTBD | W80-62 | 1-3 | .250 | - | | Tom Gola Arena · Philadelphia, PA |
| 6 | Wed Dec 9 | vsUMass | PPD | 9-16 | .360 | - | | Tom Gola Arena · Philadelphia, PA |
| 7 | Sat Dec 12 | atDrexel | W58-48 | 2-3 | .400 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 8 | Wed Dec 16 | vsUMass | L66-85 | 2-4 | .333 | - | | Tom Gola Arena · Philadelphia, PA |
| 9 | Sat Dec 19 | vsDelaware | W71-61 | 3-4 | .429 | - | NBCSN | Tom Gola Arena · Philadelphia, PA |
| 10 | Tue Dec 22 | atMaryland | L71-84 | 3-5 | .375 | - | BTN | XFINITY Center · College Park, MD |
| 11 | Wed Dec 30 | atDayton | W67-65 | 4-5 | .444 | - | | UD Arena · Dayton, OH |
| 12 | Sat Jan 2 | vsFordham | W89-52 | 5-5 | .500 | - | NBCSN | Tom Gola Arena · Philadelphia, PA |
| 13 | Wed Jan 6 | vs23Saint Louis | PPD | 9-16 | .360 | - | | Tom Gola Arena · Philadelphia, PA |
| 14 | Sat Jan 9 | atUMass | L67-83 | 5-6 | .455 | - | NBCSN | William D. Mullins Memorial Center · Amherst, MA |
| 15 | Wed Jan 13 | atGeorge Mason | L42-75 | 5-7 | .417 | - | | EagleBank Arena · Fairfax, VA |
| 16 | Sat Jan 16 | vsDavidson | L53-77 | 5-8 | .385 | - | | Tom Gola Arena · Philadelphia, PA |
| 17 | Mon Jan 18 | vsSaint Joseph's | W90-83 | 6-8 | .429 | - | CBSSN | Tom Gola Arena · Philadelphia, PA |
| 18 | Sat Jan 23 | atRichmond | W84-78 | 7-8 | .467 | - | NBCSN | Robins Center · Richmond, VA |
| 19 | Wed Jan 27 | vsRhode Island | L60-73 | 7-9 | .438 | - | | Tom Gola Arena · Philadelphia, PA |
| 20 | Sat Jan 30 | atVCU | L62-73 | 7-10 | .412 | - | NBCSN | Stuart C. Siegel Center · Richmond, VA |
| 21 | Wed Feb 3 | vsSaint Louis | W82-75 | 8-10 | .444 | - | | Tom Gola Arena · Philadelphia, PA |
| 22 | Sat Feb 6 | atFordham | L68-76 | 8-11 | .421 | - | NBCSN | Rose Hill Gymnasium · Bronx, NY |
| 23 | Tue Feb 9 | atSt Bonaventure | L73-86 | 8-12 | .400 | - | | Reilly Center · Saint Bonaventure, NY |
| 25 | Tue Feb 16 | atSaint Louis | L57-78 | 8-13 | .381 | - | CBSSN | Chaifetz Arena · St. Louis, MO |
| 26 | Sat Feb 20 | atSaint Joseph's | L82-91 (OT) | 8-14 | .364 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 27 | Wed Feb 24 | vsDuquesne | W85-65 | 9-14 | .391 | - | | Tom Gola Arena · Philadelphia, PA |
| 28 | Sat Feb 27 | atGeorge Mason | L54-89 | 9-15 | .375 | - | | EagleBank Arena · Fairfax, VA |
| 29 | Wed Mar 3 | vsSaint Joseph's | L66-72 | 9-16 | .360 | - | | Stuart C. Siegel Center · Richmond, VA |
