| 1 | Mon Nov 7 | at 16Villanova | L68-81 | 0-1 | .000 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 2 | Sat Nov 12 | vsWagner | W77-69 | 1-1 | .500 | - | | Tom Gola Arena · Philadelphia, PA |
| 3 | Tue Nov 15 | vsQueens | W72-60 | 2-1 | .667 | - | | Tom Gola Arena · Philadelphia, PA |
| 4 | Fri Nov 18 | atWake Forest | L63-75 | 2-2 | .500 | - | CBSSN | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 5 | Sun Nov 20 | atGeorgetown | L62-69 | 2-3 | .400 | - | | Capital One Arena · Washington, D.C. |
| 6 | Sat Nov 26 | vsBinghamton | W65-62 | 3-3 | .500 | - | | Tom Gola Arena · Philadelphia, PA |
| 7 | Wed Nov 30 | vsTemple | L51-67 | 3-4 | .429 | - | | The Palestra · Philadelphia, PA |
| 8 | Sat Dec 3 | atPenn | W84-81 (OT) | 4-4 | .500 | - | | The Palestra · Philadelphia, PA |
| 9 | Tue Dec 6 | vsBucknell | W82-72 | 5-4 | .556 | - | | Tom Gola Arena · Philadelphia, PA |
| 10 | Sat Dec 10 | vsDrexel | L58-65 (OT) | 5-5 | .500 | - | | Tom Gola Arena · Philadelphia, PA |
| 11 | Sat Dec 17 | atCincinnati | L60-78 | 5-6 | .455 | - | | Fifth Third Arena · Cincinnati, OH |
| 12 | Wed Dec 21 | vsLafayette | L65-90 | 5-7 | .417 | - | | Tom Gola Arena · Philadelphia, PA |
| 13 | Thu Dec 29 | atHoward | W80-76 | 6-7 | .462 | - | | Burr Gymnasium · Washington, D.C. |
| 14 | Sat Dec 31 | atVCU | L67-80 | 6-8 | .429 | - | | Stuart C. Siegel Center · Richmond, VA |
| 15 | Sat Jan 7 | vsRhode Island | W77-75 (OT) | 7-8 | .467 | - | | Tom Gola Arena · Philadelphia, PA |
| 16 | Wed Jan 11 | atUMass | W78-77 | 8-8 | .500 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 17 | Sat Jan 14 | vsFordham | L64-66 | 8-9 | .471 | - | | Tom Gola Arena · Philadelphia, PA |
| 18 | Mon Jan 16 | vsSaint Joseph's | L59-71 | 8-10 | .444 | - | CBSSN | Tom Gola Arena · Philadelphia, PA |
| 19 | Sat Jan 21 | atSaint Louis | L71-84 | 8-11 | .421 | - | USA Net | Chaifetz Arena · St. Louis, MO |
| 20 | Tue Jan 24 | vsDavidson | L57-64 | 8-12 | .400 | - | | Tom Gola Arena · Philadelphia, PA |
| 21 | Sat Jan 28 | atRhode Island | L70-72 | 8-13 | .381 | - | | Ryan Center · Kingston, RI |
| 22 | Wed Feb 1 | vsG Washington | W75-64 | 9-13 | .409 | - | | Tom Gola Arena · Philadelphia, PA |
| 23 | Sun Feb 5 | atSaint Joseph's | W73-65 | 10-13 | .435 | - | ESPNU | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 24 | Wed Feb 8 | atSt Bonaventure | W76-70 | 11-13 | .458 | - | | Reilly Center · Saint Bonaventure, NY |
| 25 | Sat Feb 11 | vsUMass | W86-72 | 12-13 | .480 | - | | Tom Gola Arena · Philadelphia, PA |
| 26 | Wed Feb 15 | vsRichmond | W68-62 | 13-13 | .500 | - | | Tom Gola Arena · Philadelphia, PA |
| 27 | Sat Feb 18 | atGeorge Mason | L66-70 | 13-14 | .481 | - | | EagleBank Arena · Fairfax, VA |
| 28 | Wed Feb 22 | vsDuquesne | L74-91 | 13-15 | .464 | - | | Tom Gola Arena · Philadelphia, PA |
| 29 | Sat Feb 25 | atG Washington | L85-92 | 13-16 | .448 | - | | Charles E. Smith Center · Washington, D.C. |
| 30 | Tue Feb 28 | atDayton | L53-77 | 13-17 | .433 | - | | UD Arena · Dayton, OH |
| 31 | Sat Mar 4 | vsLoyola Chicago | L73-76 | 13-18 | .419 | - | | Tom Gola Arena · Philadelphia, PA |
| 32 | Tue Mar 7 | vsRhode Island | W73-56 | 14-18 | .438 | - | | Tom Gola Arena · Philadelphia, PA |
| 33 | Wed Mar 8 | atDuquesne | W81-70 | 15-18 | .455 | - | USA Net | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 34 | Thu Mar 9 | atFordham | L61-69 | 15-19 | .441 | - | USA Net | Rose Hill Gymnasium · Bronx, NY |
