| 1 | Wed Nov 5 | vs Coppin St | 6:30 PM | 6-24 | .200 | - | ESPN+ | Tom Gola Arena · Philadelphia, PA |
| 2 | Sat Nov 8 | vsMonmouth | 3:30 PM | 13-20 | .394 | - | ESPN+ | Tom Gola Arena · Philadelphia, PA |
| 3 | Tue Nov 11 | atTemple | 7:00 PM | 17-15 | .531 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 4 | Sat Nov 15 | vsPenn State | 1:00 PM | 16-15 | .516 | - | Peacock | Tom Gola Arena · Philadelphia, PA |
| 5 | Wed Nov 19 | vsVillanova | TBD | 21-15 | .583 | - | | Tom Gola Arena · Philadelphia, PA |
| 6 | Sat Nov 22 | vsTBD | 5:00 PM | 0-0 | .000 | - | ESPN+ | Tom Gola Arena · Philadelphia, PA |
| 7 | Fri Nov 28 | atHofstra | 2:00 PM | 15-18 | .455 | - | ESPN+ | David S. Mack Sports and Exhibition Complex · Hempstead, NY |
| 8 | Sat Nov 29 | atPenn | 4:30 PM | 8-19 | .296 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 9 | Sun Nov 30 | vsMerrimack | 12:00 PM | 18-15 | .545 | - | ESPN+ | Tom Gola Arena · Philadelphia, PA |
| 10 | Sat Dec 13 | atLong Island | TBD | 17-16 | .515 | - | | Steinberg Wellness Center · Brooklyn, NY |
| 11 | Fri Dec 19 | atHigh Point | 7:00 PM | 29-6 | .829 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 12 | Sun Dec 21 | at#7Michigan | 4:00 PM | 27-10 | .730 | - | | Crisler Center · Ann Arbor, MI |
| 13 | Wed Dec 31 | vsGeorge Mason | 2:00 PM | 27-9 | .750 | - | | Tom Gola Arena · Philadelphia, PA |
| 14 | Sat Jan 3 | atG Washington | 2:00 PM | 21-13 | .618 | - | | Charles E. Smith Center · Washington, D.C. |
| 15 | Wed Jan 7 | atRhode Island | 7:00 PM | 18-13 | .581 | - | | Ryan Center · Kingston, RI |
| 16 | Sat Jan 10 | vsSaint Louis | 4:00 PM | 19-15 | .559 | - | | Tom Gola Arena · Philadelphia, PA |
| 17 | Wed Jan 14 | atRichmond | 7:00 PM | 10-22 | .313 | - | | Robins Center · Richmond, VA |
| 18 | Sat Jan 17 | vsSt Bonaventure | 2:30 PM | 22-12 | .647 | - | | Tom Gola Arena · Philadelphia, PA |
| 19 | Wed Jan 21 | vsDayton | TBD | 23-11 | .676 | - | | Tom Gola Arena · Philadelphia, PA |
| 20 | Wed Jan 28 | atFordham | 7:00 PM | 12-21 | .364 | - | | Rose Hill Gymnasium · Bronx, NY |
| 21 | Sat Jan 31 | vsSaint Joseph's | 2:30 PM | 22-13 | .629 | - | | Tom Gola Arena · Philadelphia, PA |
| 22 | Tue Feb 3 | atLoyola Chicago | 7:00 PM | 25-12 | .676 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 23 | Sat Feb 7 | atSaint Louis | TBD | 19-15 | .559 | - | | Chaifetz Arena · St. Louis, MO |
| 24 | Wed Feb 11 | vsVCU | 6:30 PM | 28-7 | .800 | - | | Tom Gola Arena · Philadelphia, PA |
| 25 | Wed Feb 18 | atDuquesne | 7:00 PM | 13-19 | .406 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 26 | Sat Feb 21 | vsRhode Island | 2:30 PM | 18-13 | .581 | - | | Tom Gola Arena · Philadelphia, PA |
| 27 | Tue Feb 24 | vsG Washington | 6:30 PM | 21-13 | .618 | - | | Tom Gola Arena · Philadelphia, PA |
| 28 | Sun Mar 1 | atDavidson | 12:00 PM | 17-16 | .515 | - | | John M. Belk Arena · Davidson, NC |
| 29 | Wed Mar 4 | vsFordham | 6:30 PM | 12-21 | .364 | - | | Tom Gola Arena · Philadelphia, PA |
| 30 | Sat Mar 7 | atSaint Joseph's | 1:00 PM | 22-13 | .629 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
