| 3 | Tue Nov 11 | at Temple | 7:00 PM | 1-0 | 1.000 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 4 | Sat Nov 15 | vsPenn State | 1:00 PM | 2-0 | 1.000 | - | Peacock | Tom Gola Arena · Philadelphia, PA |
| 5 | Wed Nov 19 | vsVillanova | 7:00 PM | 0-1 | .000 | - | CBS | Tom Gola Arena · Philadelphia, PA |
| 6 | Sat Nov 22 | vsTBD | 5:00 PM | 0-0 | .000 | - | ESPN+ | Tom Gola Arena · Philadelphia, PA |
| 7 | Fri Nov 28 | vsHofstra | 2:00 PM | 0-2 | .000 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 8 | Sat Nov 29 | atPenn | 4:30 PM | 1-0 | 1.000 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 9 | Sun Nov 30 | vsMerrimack | 12:00 PM | 0-2 | .000 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 10 | Sat Dec 13 | atLong Island | 4:00 PM | 1-1 | .500 | - | | Steinberg Wellness Center · Brooklyn, NY |
| 11 | Fri Dec 19 | atHigh Point | 7:00 PM | 2-0 | 1.000 | - | ESPN+ | Nido and Mariana Qubein Arena · High Point, NC |
| 12 | Sun Dec 21 | at#7Michigan | 4:00 PM | 1-0 | 1.000 | - | | Crisler Center · Ann Arbor, MI |
| 13 | Wed Dec 31 | vsGeorge Mason | 2:00 PM | 2-0 | 1.000 | - | ESPN+ | Tom Gola Arena · Philadelphia, PA |
| 14 | Sat Jan 3 | atG Washington | 2:00 PM | 2-0 | 1.000 | - | | Charles E. Smith Center · Washington, D.C. |
| 15 | Wed Jan 7 | atRhode Island | 7:00 PM | 1-1 | .500 | - | ESPN+ | Ryan Center · Kingston, RI |
| 16 | Sat Jan 10 | vsSaint Louis | 4:00 PM | 2-0 | 1.000 | - | | Tom Gola Arena · Philadelphia, PA |
| 17 | Wed Jan 14 | atRichmond | 7:00 PM | 1-0 | 1.000 | - | ESPN+ | Robins Center · Richmond, VA |
| 18 | Sat Jan 17 | vsSt Bonaventure | 2:30 PM | 2-0 | 1.000 | - | | Tom Gola Arena · Philadelphia, PA |
| 19 | Wed Jan 21 | vsDayton | 6:30 PM | 2-0 | 1.000 | - | ESPN+ | Tom Gola Arena · Philadelphia, PA |
| 20 | Wed Jan 28 | atFordham | 7:00 PM | 1-1 | .500 | - | ESPN+ | Rose Hill Gymnasium · Bronx, NY |
| 21 | Sat Jan 31 | vsSaint Joseph's | 2:30 PM | 2-0 | 1.000 | - | | Tom Gola Arena · Philadelphia, PA |
| 22 | Tue Feb 3 | atLoyola Chicago | 7:00 PM | 1-1 | .500 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 23 | Sat Feb 7 | atSaint Louis | 3:00 PM | 2-0 | 1.000 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 24 | Wed Feb 11 | vsVCU | 6:30 PM | 1-1 | .500 | - | ESPN+ | Tom Gola Arena · Philadelphia, PA |
| 25 | Wed Feb 18 | atDuquesne | 7:00 PM | 2-0 | 1.000 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 26 | Sat Feb 21 | vsRhode Island | 2:30 PM | 1-1 | .500 | - | ESPN+ | Tom Gola Arena · Philadelphia, PA |
| 27 | Tue Feb 24 | vsG Washington | 6:30 PM | 2-0 | 1.000 | - | ESPN+ | Tom Gola Arena · Philadelphia, PA |
| 28 | Sun Mar 1 | atDavidson | 12:00 PM | 2-0 | 1.000 | - | | John M. Belk Arena · Davidson, NC |
| 29 | Wed Mar 4 | vsFordham | 6:30 PM | 1-1 | .500 | - | ESPN+ | Tom Gola Arena · Philadelphia, PA |
| 30 | Sat Mar 7 | atSaint Joseph's | 1:00 PM | 2-0 | 1.000 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
