| 1 | Mon Nov 3 | at Northwestern | L47-70 | 0-1 | .000 | - | B1G+ | Welsh-Ryan Arena · Evanston, IL |
| 2 | Thu Nov 6 | atLoyola Chicago | W73-65 | 1-1 | .500 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 3 | Sat Nov 8 | vsTBD | W94-43 | 2-1 | .667 | - | | Mercyhurst Athletic Center · Erie, PA |
| 4 | Wed Nov 12 | atCanisius | L55-58 | 2-2 | .500 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 5 | Sat Nov 15 | vsMorgan St | W86-72 | 3-2 | .600 | - | | Mercyhurst Athletic Center · Erie, PA |
| 6 | Thu Nov 20 | atMiami OH | L71-76 | 3-3 | .500 | - | ESPN+ | Millett Hall · Oxford, OH |
| 7 | Sun Nov 23 | atMarshall | L60-69 | 3-4 | .429 | - | ESPN+ | Cam Henderson Center · Huntington, WV |
| 8 | Sun Nov 30 | atWest Virginia | L38-70 | 3-5 | .375 | - | ESPN+ | WVU Coliseum · Morgantown, WV |
| 9 | Fri Dec 5 | atLafayette | L71-79 | 3-6 | .333 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 10 | Sun Dec 7 | vsTBD | W80-51 | 4-6 | .400 | - | | Mercyhurst Athletic Center · Erie, PA |
| 11 | Sat Dec 13 | atDavidson | L47-80 | 4-7 | .364 | - | ESPN+ | John M. Belk Arena · Davidson, NC |
| 12 | Wed Dec 17 | atSyracuse | L62-76 | 4-8 | .333 | - | ACC Extra | JMA Wireless Dome · Syracuse, NY |
| 13 | Sat Dec 20 | vsBinghamton | W82-61 | 5-8 | .385 | - | | Mercyhurst Athletic Center · Erie, PA |
| 14 | Fri Jan 2 | vsFairleigh | L67-74 | 5-9 | .357 | - | | Mercyhurst Athletic Center · Erie, PA |
| 15 | Sun Jan 4 | vsLe Moyne | W74-60 | 6-9 | .400 | - | | Mercyhurst Athletic Center · Erie, PA |
| 16 | Thu Jan 8 | atLong Island | L58-60 | 6-10 | .375 | - | | Steinberg Wellness Center · Brooklyn, NY |
| 17 | Sat Jan 10 | atWagner | W70-69 | 7-10 | .412 | - | | Spiro Sports Center · Staten Island, NY |
| 18 | Sat Jan 17 | vsStonehill | L57-62 (OT) | 7-11 | .389 | - | | Mercyhurst Athletic Center · Erie, PA |
| 19 | Mon Jan 19 | vsC Connecticut | W79-61 | 8-11 | .421 | - | | Mercyhurst Athletic Center · Erie, PA |
| 20 | Fri Jan 23 | atNew Haven | W61-57 | 9-11 | .450 | - | | Jeffery P. Hazell Athletics Center |
| 21 | Sun Jan 25 | vsChicago St | W61-59 | 10-11 | .476 | - | | Mercyhurst Athletic Center · Erie, PA |
| 22 | Thu Jan 29 | vsNew Haven | W70-51 | 11-11 | .500 | - | | Mercyhurst Athletic Center · Erie, PA |
| 23 | Sat Jan 31 | atChicago St | L74-78 | 11-12 | .478 | - | | Jones Convocation Center · Chicago, IL |
| 24 | Thu Feb 5 | vsSt Francis PA | W98-89 (OT) | 12-12 | .500 | - | ESPN+ | Mercyhurst Athletic Center · Erie, PA |
| 25 | Sat Feb 7 | atFairleigh | L52-55 | 12-13 | .480 | - | | Stratis Arena at the Rothman Center · Teaneck, NJ |
| 26 | Thu Feb 12 | atLe Moyne | L57-58 | 12-14 | .462 | - | | Ted Grant Court · Syracuse, NY |
| 27 | Sat Feb 14 | atSt Francis PA | W94-79 | 13-14 | .481 | - | | DeGol Arena · Loretto, PA |
| 28 | Thu Feb 19 | vsWagner | L80-83 (OT) | 13-15 | .464 | - | | Mercyhurst Athletic Center · Erie, PA |
| 29 | Sat Feb 21 | vsLong Island | W91-83 | 14-15 | .483 | - | | Mercyhurst Athletic Center · Erie, PA |
| 30 | Thu Feb 26 | atC Connecticut | L78-80 | 14-16 | .467 | - | | William H. Detrick Gymnasium · New Britain, CT |
| 31 | Sat Feb 28 | atStonehill | W75-72 (OT) | 15-16 | .484 | - | | placeholder · sf, ca |
