| 1 | Mon Nov 3 | at Northwestern | 8:00 PM | 17-16 | .515 | - | B1G+ | Welsh-Ryan Arena · Evanston, IL |
| 2 | Thu Nov 6 | atLoyola Chicago | TBD | 25-12 | .676 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 3 | Sat Nov 8 | vsTBD | 3:00 PM | 0-0 | .000 | - | | Mercyhurst Athletic Center · Erie, PA |
| 4 | Wed Nov 12 | atCanisius | TBD | 3-28 | .097 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 5 | Sat Nov 15 | vsMorgan St | 4:00 PM | 14-18 | .438 | - | | Mercyhurst Athletic Center · Erie, PA |
| 6 | Thu Nov 20 | atMiami OH | TBD | 25-9 | .735 | - | ESPN+ | Millett Hall · Oxford, OH |
| 7 | Sun Nov 23 | atMarshall | 7:00 PM | 20-13 | .606 | - | | Cam Henderson Center · Huntington, WV |
| 8 | Sun Nov 30 | atWest Virginia | 3:00 PM | 19-13 | .594 | - | ESPN+ | WVU Coliseum · Morgantown, WV |
| 9 | Fri Dec 5 | atLafayette | 7:00 PM | 13-20 | .394 | - | | Kirby Sports Center · Easton, PA |
| 10 | Sun Dec 7 | vsTBD | 2:00 PM | 0-0 | .000 | - | | Mercyhurst Athletic Center · Erie, PA |
| 11 | Sat Dec 13 | atDavidson | TBD | 17-16 | .515 | - | | John M. Belk Arena · Davidson, NC |
| 12 | Wed Dec 17 | atSyracuse | TBD | 14-19 | .424 | - | | JMA Wireless Dome · Syracuse, NY |
| 13 | Sat Dec 20 | vsBinghamton | 2:00 PM | 15-17 | .469 | - | | Mercyhurst Athletic Center · Erie, PA |
| 14 | Fri Jan 2 | vsFairleigh | 7:30 PM | 13-20 | .394 | - | | Mercyhurst Athletic Center · Erie, PA |
| 15 | Sun Jan 4 | vsLe Moyne | TBD | 9-23 | .281 | - | | Mercyhurst Athletic Center · Erie, PA |
| 16 | Thu Jan 8 | atLong Island | TBD | 17-16 | .515 | - | | Steinberg Wellness Center · Brooklyn, NY |
| 17 | Sat Jan 10 | atWagner | TBD | 14-16 | .467 | - | | Spiro Sports Center · Staten Island, NY |
| 18 | Sat Jan 17 | vsStonehill | 2:00 PM | 15-17 | .469 | - | | Mercyhurst Athletic Center · Erie, PA |
| 19 | Mon Jan 19 | vsC Connecticut | 2:00 PM | 25-7 | .781 | - | | Mercyhurst Athletic Center · Erie, PA |
| 20 | Fri Jan 23 | atNew Haven | 6:00 PM | 0-0 | .000 | - | | Jeffery P. Hazell Athletics Center |
| 21 | Sun Jan 25 | vsChicago St | 2:00 PM | 4-28 | .125 | - | | Mercyhurst Athletic Center · Erie, PA |
| 22 | Thu Jan 29 | vsNew Haven | 7:00 PM | 0-0 | .000 | - | | Mercyhurst Athletic Center · Erie, PA |
| 23 | Sat Jan 31 | atChicago St | TBD | 4-28 | .125 | - | | Jones Convocation Center · Chicago, IL |
| 24 | Thu Feb 5 | vsSt Francis PA | 7:00 PM | 16-18 | .471 | - | | Mercyhurst Athletic Center · Erie, PA |
| 25 | Sat Feb 7 | atFairleigh | 3:30 PM | 13-20 | .394 | - | | Stratis Arena at the Rothman Center · Teaneck, NJ |
| 26 | Thu Feb 12 | atLe Moyne | 7:00 PM | 9-23 | .281 | - | | Ted Grant Court · Syracuse, NY |
| 27 | Sat Feb 14 | atSt Francis PA | TBD | 16-18 | .471 | - | | DeGol Arena · Loretto, PA |
| 28 | Thu Feb 19 | vsWagner | 7:00 PM | 14-16 | .467 | - | | Mercyhurst Athletic Center · Erie, PA |
| 29 | Sat Feb 21 | vsLong Island | 2:00 PM | 17-16 | .515 | - | | Mercyhurst Athletic Center · Erie, PA |
| 30 | Thu Feb 26 | atC Connecticut | 7:00 PM | 25-7 | .781 | - | | William H. Detrick Gymnasium · New Britain, CT |
| 31 | Sat Feb 28 | atStonehill | 2:00 PM | 15-17 | .469 | - | | placeholder · sf, ca |
