| 1 | Mon Nov 3 | at Dayton | L48-88 | 0-1 | .000 | - | ESPN+ | UD Arena · Dayton, OH |
| 2 | Thu Nov 6 | vsTBD | W84-43 | 1-1 | .500 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 3 | Sat Nov 8 | atSt Bonaventure | L70-89 | 1-2 | .333 | - | ESPN+ | Reilly Center · Saint Bonaventure, NY |
| 4 | Wed Nov 12 | vsMercyhurst | W58-55 | 2-2 | .500 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 5 | Mon Nov 17 | atHigh Point | L50-93 | 2-3 | .400 | - | ESPN+ | Nido and Mariana Qubein Arena · High Point, NC |
| 6 | Fri Nov 21 | vsMD-Eastern | W60-57 | 3-3 | .500 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 7 | Sun Nov 23 | vsBinghamton | W75-66 | 4-3 | .571 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 8 | Sat Nov 29 | vsBuffalo | L53-71 | 4-4 | .500 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 9 | Fri Dec 5 | atSaint Peter's | L57-69 | 4-5 | .444 | - | ESPN+ | Yanitelli Center · Jersey City, NJ |
| 10 | Sun Dec 7 | atSiena | L52-74 | 4-6 | .400 | - | ESPN+ | MVP Arena · Albany, NY |
| 11 | Sat Dec 13 | atMaine | W70-43 | 5-6 | .455 | - | ESPN+ | Cross Insurance Center · Bangor, ME |
| 12 | Tue Dec 16 | atRhode Island | L45-62 | 5-7 | .417 | - | ESPN+ | Ryan Center · Kingston, RI |
| 13 | Mon Dec 22 | atDuquesne | L59-103 | 5-8 | .385 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 14 | Fri Jan 2 | vsFairfield | W85-81 | 6-8 | .429 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 15 | Sun Jan 4 | vsSacred Heart | W82-78 | 7-8 | .467 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 16 | Fri Jan 9 | atManhattan | W70-64 | 8-8 | .500 | - | ESPN+ | Draddy Gymnasium · Riverdale, NY |
| 17 | Sun Jan 11 | atIona | L48-74 | 8-9 | .471 | - | ESPN+ | Hynes Athletics Center · New Rochelle, NY |
| 18 | Wed Jan 14 | vsNiagara | L54-59 | 8-10 | .444 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 19 | Sat Jan 17 | vsMount St Mary | L68-78 | 8-11 | .421 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 20 | Thu Jan 22 | atSacred Heart | L66-69 | 8-12 | .400 | - | ESPN+ | William H. Pitt Center · Fairfield, CT |
| 21 | Sat Jan 24 | atFairfield | L55-61 | 8-13 | .381 | - | ESPN+ | Leo D. Mahoney Arena · Fairfield, CT |
| 22 | Fri Jan 30 | vsMarist | L86-88 (OT) | 8-14 | .364 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 23 | Sun Feb 1 | vsSiena | L63-78 | 8-15 | .348 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 24 | Tue Feb 3 | atNiagara | L56-65 | 8-16 | .333 | - | ESPN+ | Gallagher Center · Niagara Falls, NY |
| 25 | Thu Feb 5 | atQuinnipiac | L60-75 | 8-17 | .320 | - | ESPN+ | M&T Bank Arena · Hamden, CT |
| 26 | Fri Feb 13 | vsIona | L63-69 | 8-18 | .308 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 27 | Sun Feb 15 | vsManhattan | L65-69 | 8-19 | .296 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 28 | Fri Feb 20 | atRider | W72-66 | 9-19 | .321 | - | ESPN+ | Alumni Gymnasium (Rider) · Lawrenceville, NJ |
| 29 | Sun Feb 22 | atMount St Mary | L47-68 | 9-20 | .310 | - | ESPN+ | Knott Arena · Emmitsburg, MD |
| 30 | Fri Feb 27 | vsMerrimack | W67-62 | 10-20 | .333 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 31 | Sun Mar 1 | vsQuinnipiac | L63-67 | 10-21 | .323 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
