| 1 | Tue Nov 9 | at Miami | L67-77 | 0-1 | .000 | - | | Watsco Center · Coral Gables, FL |
| 2 | Fri Nov 12 | at E Carolina | L71-83 | 0-2 | .000 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 3 | Sun Nov 14 | at #23St Bonaventure | L60-69 | 0-3 | .000 | - | | Reilly Center · Saint Bonaventure, NY |
| 4 | Sat Nov 20 | at Cleveland St | L70-80 | 0-4 | .000 | - | | Wolstein Center · Cleveland, OH |
| 5 | Mon Nov 22 | vs TBD | W106-40 | 1-4 | .200 | - | | Koessler Athletic Center · Buffalo, NY |
| 6 | Wed Nov 24 | vs Coppin St | W76-75 | 2-4 | .333 | - | | Koessler Athletic Center · Buffalo, NY |
| 7 | Mon Nov 29 | vs Cornell | L75-89 | 2-5 | .286 | - | | Koessler Athletic Center · Buffalo, NY |
| 8 | Fri Dec 3 | vs Fairfield | L68-74 | 2-6 | .250 | - | | Koessler Athletic Center · Buffalo, NY |
| 9 | Sun Dec 5 | vs Monmouth | L65-79 | 2-7 | .222 | - | | Koessler Athletic Center · Buffalo, NY |
| 10 | Wed Dec 8 | at N Kentucky | L62-75 | 2-8 | .200 | - | | Truist Arena · Highland Heights, KY |
| 11 | Sat Dec 11 | at Youngstown St | L43-71 | 2-9 | .182 | - | | Beeghly Center · Youngstown, OH |
| 12 | Sat Dec 18 | vs Buffalo | W65-64 | 3-9 | .250 | - | | Koessler Athletic Center · Buffalo, NY |
| 13 | Wed Dec 22 | vs FGCU | W97-90 (OT) | 4-9 | .308 | - | | Koessler Athletic Center · Buffalo, NY |
| 14 | Fri Dec 31 | at Saint Peter's | PPD | 11-21 | .344 | - | | Yanitelli Center · Jersey City, NJ |
| 15 | Sun Jan 2 | at Siena | PPD | 11-21 | .344 | - | | MVP Arena · Albany, NY |
| 16 | Tue Jan 11 | vs Quinnipiac | W79-67 | 5-9 | .357 | - | | Koessler Athletic Center · Buffalo, NY |
| 17 | Thu Jan 13 | at Niagara | L58-68 | 5-10 | .333 | - | | Gallagher Center · Niagara Falls, NY |
| 18 | Sun Jan 16 | at Manhattan | L75-80 | 5-11 | .313 | - | | Draddy Gymnasium · Riverdale, NY |
| 19 | Tue Jan 18 | atSaint Peter's | L57-65 | 5-12 | .294 | - | | Yanitelli Center · Jersey City, NJ |
| 20 | Fri Jan 21 | vs Rider | W70-69 | 11-21 | .344 | - | | Koessler Athletic Center · Buffalo, NY |
| 21 | Sun Jan 23 | vsSaint Peter's | W63-60 | 7-12 | .368 | - | | Koessler Athletic Center · Buffalo, NY |
| 22 | Fri Jan 28 | atMonmouth | L67-72 | 7-13 | .350 | - | | OceanFirst Bank Center · West Long Branch, NJ |
| 23 | Sun Jan 30 | atRider | L62-70 | 7-14 | .333 | - | | Alumni Gymnasium (Rider) · Lawrenceville, NJ |
| 24 | Tue Feb 1 | atSiena | L65-73 | 7-15 | .318 | - | | MVP Arena · Albany, NY |
| 25 | Fri Feb 4 | vs Iona | L62-70 | 7-16 | .304 | - | | Koessler Athletic Center · Buffalo, NY |
| 26 | Sun Feb 6 | vsManhattan | W77-70 | 8-16 | .333 | - | | Koessler Athletic Center · Buffalo, NY |
| 27 | Sat Feb 12 | at Marist | L70-71 | 8-17 | .320 | - | | McCann Arena · Poughkeepsie, NY |
| 28 | Mon Feb 14 | atFairfield | L76-80 (OT) | 8-18 | .308 | - | | Leo D. Mahoney Arena · Fairfield, CT |
| 29 | Sat Feb 19 | vsNiagara | L54-65 | 8-19 | .296 | - | | Koessler Athletic Center · Buffalo, NY |
| 30 | Fri Feb 25 | atIona | L65-72 | 8-20 | .286 | - | | Hynes Athletics Center · New Rochelle, NY |
| 31 | Sun Feb 27 | atQuinnipiac | W72-67 | 9-20 | .310 | - | | M&T Bank Arena · Hamden, CT |
| 32 | Thu Mar 3 | vsMarist | W78-67 | 10-20 | .333 | - | | Koessler Athletic Center · Buffalo, NY |
| 33 | Sat Mar 5 | vsSiena | W67-64 | 11-20 | .355 | - | | Koessler Athletic Center · Buffalo, NY |
| 34 | Tue Mar 8 | atFairfield | L50-72 | 11-21 | .344 | - | | Leo D. Mahoney Arena · Fairfield, CT |
