| 1 | Mon Nov 7 | vs TBD | L68-72 | 0-1 | .000 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 2 | Thu Nov 10 | atCincinnati | L58-69 | 0-2 | .000 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 3 | Sat Nov 12 | atOhio | L70-81 | 0-3 | .000 | - | ESPN3 | Convocation Center (OH) · Athens, OH |
| 4 | Wed Nov 16 | atCanisius | W58-57 (OT) | 1-3 | .250 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 5 | Fri Nov 18 | vsAR-Pine Bluff | W67-58 | 2-3 | .400 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 6 | Wed Nov 23 | vsChicago St | W77-63 | 3-3 | .500 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 7 | Sat Nov 26 | atW Michigan | W71-49 | 4-3 | .571 | - | ESPN3 | University Arena (MI) · Kalamazoo, MI |
| 8 | Thu Dec 1 | vsOakland | W80-64 | 5-3 | .625 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 9 | Sat Dec 3 | vsDetroit Mercy | W92-77 | 6-3 | .667 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 10 | Wed Dec 7 | atSt Bonaventure | L42-61 | 6-4 | .600 | - | ESPN+ | Reilly Center · Saint Bonaventure, NY |
| 11 | Sat Dec 10 | vsKent State | L58-67 | 6-5 | .545 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 12 | Sun Dec 18 | atLMU | L59-70 | 6-6 | .500 | - | | Gersten Pavilion · Los Angeles, CA |
| 13 | Wed Dec 21 | vsTBD | W78-48 | 7-6 | .538 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 14 | Thu Dec 29 | atYoungstown St | L71-85 | 7-7 | .500 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 15 | Sat Dec 31 | atRobert Morris | W63-54 | 8-7 | .533 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 16 | Thu Jan 5 | vsMilwaukee | L64-68 (OT) | 8-8 | .500 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 17 | Sat Jan 7 | vsGreen Bay | W82-77 | 9-8 | .529 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 18 | Sat Jan 14 | atIU Indy | W89-54 | 10-8 | .556 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 19 | Mon Jan 16 | atPurdue FW | W72-60 | 11-8 | .579 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 20 | Thu Jan 19 | atN Kentucky | L56-57 | 11-9 | .550 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 21 | Sat Jan 21 | atWright St | W85-77 | 12-9 | .571 | - | ESPN+ | Nutter Center · Dayton, OH |
| 22 | Fri Jan 27 | vsPurdue FW | W79-74 | 13-9 | .591 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 23 | Sun Jan 29 | vsIU Indy | W78-72 | 14-9 | .609 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 24 | Thu Feb 2 | atDetroit Mercy | L67-85 | 14-10 | .583 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 25 | Sat Feb 4 | atOakland | L89-92 (OT) | 14-11 | .560 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 26 | Fri Feb 10 | vsRobert Morris | W57-55 | 15-11 | .577 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 27 | Sun Feb 12 | vsYoungstown St | W81-78 | 16-11 | .593 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 28 | Fri Feb 17 | vsWright St | W85-68 | 17-11 | .607 | - | ESPNU | Wolstein Center · Cleveland, OH |
| 29 | Sun Feb 19 | vsN Kentucky | W64-63 | 18-11 | .621 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 30 | Thu Feb 23 | atGreen Bay | W76-65 | 19-11 | .633 | - | ESPN+ | Resch Center · Ashwaubenon, WI |
| 31 | Sat Feb 25 | atMilwaukee | L72-81 | 19-12 | .613 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 32 | Thu Mar 2 | vsRobert Morris | W75-70 (OT) | 20-12 | .625 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 33 | Mon Mar 6 | atMilwaukee | W93-80 | 21-12 | .636 | - | ESPN2 | Indiana Farmers Coliseum · Indianapolis, IN |
| 34 | Tue Mar 7 | vsN Kentucky | L61-63 | 21-13 | .618 | - | ESPN | Indiana Farmers Coliseum · Indianapolis, IN |
| 35 | Sun Mar 19 | atE Kentucky | L75-91 (OT) | 21-14 | .600 | - | | McBrayer Arena · Richmond, KY |
