| 1 | Mon Nov 3 | at Loyola Chicago | 8:00 PM | 25-12 | .676 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 2 | Thu Nov 6 | vsTBD | 7:00 PM | 0-0 | .000 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 3 | Mon Nov 10 | atNorthwestern | TBD | 17-16 | .515 | - | | Welsh-Ryan Arena · Evanston, IL |
| 4 | Sat Nov 15 | vsKent State | 1:00 PM | 24-12 | .667 | - | | Wolstein Center · Cleveland, OH |
| 5 | Sun Nov 16 | vsRadford | 2:30 PM | 20-13 | .606 | - | | Wolstein Center · Cleveland, OH |
| 6 | Wed Nov 19 | vsValparaiso | 7:00 PM | 15-19 | .441 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 7 | Sat Nov 22 | atKent State | 2:00 PM | 24-12 | .667 | - | ESPN+ | M.A.C. Center · Kent, OH |
| 8 | Tue Nov 25 | vsTBD | 7:00 PM | 0-0 | .000 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 9 | Fri Nov 28 | atMissouri | 2:00 PM | 22-12 | .647 | - | SECN+ | Mizzou Arena · Columbia, MO |
| 10 | Wed Dec 3 | atN Kentucky | 7:00 PM | 17-16 | .515 | - | | Truist Arena · Highland Heights, KY |
| 11 | Sat Dec 6 | vsDetroit Mercy | 2:00 PM | 8-24 | .250 | - | | Wolstein Center · Cleveland, OH |
| 12 | Sun Dec 14 | vsTBD | 2:00 PM | 0-0 | .000 | - | | Wolstein Center · Cleveland, OH |
| 13 | Wed Dec 17 | atUAB | TBD | 24-13 | .649 | - | | Bartow Arena · Birmingham, AL |
| 14 | Sun Dec 21 | vsMilwaukee | 5:00 PM | 21-11 | .656 | - | | Wolstein Center · Cleveland, OH |
| 15 | Mon Dec 29 | vsIU Indy | 7:00 PM | 10-22 | .313 | - | | Wolstein Center · Cleveland, OH |
| 16 | Sun Jan 4 | atPurdue FW | 2:00 PM | 19-13 | .594 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 17 | Fri Jan 9 | atOakland | 7:00 PM | 16-18 | .471 | - | | Athletics Center O'rena · Rochester, MI |
| 18 | Sun Jan 11 | atDetroit Mercy | 1:00 PM | 8-24 | .250 | - | | Calihan Hall · Detroit, MI |
| 19 | Thu Jan 15 | vsGreen Bay | 7:00 PM | 4-28 | .125 | - | | Wolstein Center · Cleveland, OH |
| 20 | Sat Jan 17 | vsYoungstown St | 2:00 PM | 21-13 | .618 | - | | Wolstein Center · Cleveland, OH |
| 21 | Wed Jan 21 | atWright St | TBD | 15-18 | .455 | - | | Nutter Center · Dayton, OH |
| 22 | Fri Jan 30 | atGreen Bay | 7:00 PM | 4-28 | .125 | - | | Resch Center · Ashwaubenon, WI |
| 23 | Sun Feb 1 | atMilwaukee | TBD | 21-11 | .656 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 24 | Wed Feb 4 | vsOakland | 7:00 PM | 16-18 | .471 | - | | Wolstein Center · Cleveland, OH |
| 25 | Sat Feb 7 | atIU Indy | 2:00 PM | 10-22 | .313 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 26 | Thu Feb 12 | vsRobert Morris | 7:00 PM | 26-9 | .743 | - | | Wolstein Center · Cleveland, OH |
| 27 | Sun Feb 15 | vsWright St | 2:00 PM | 15-18 | .455 | - | | Wolstein Center · Cleveland, OH |
| 28 | Wed Feb 18 | atYoungstown St | 6:30 PM | 21-13 | .618 | - | | Beeghly Center · Youngstown, OH |
| 29 | Sun Feb 22 | vsPurdue FW | 2:00 PM | 19-13 | .594 | - | | Wolstein Center · Cleveland, OH |
| 30 | Wed Feb 25 | vsN Kentucky | 7:00 PM | 17-16 | .515 | - | | Wolstein Center · Cleveland, OH |
| 31 | Sat Feb 28 | atRobert Morris | 1:00 PM | 26-9 | .743 | - | | UPMC Events Center · Moon Township, PA |
