| 1 | Tue Nov 5 | at Minnesota | L50-85 | 0-1 | .000 | - | | Williams Arena · Minneapolis, MN |
| 2 | Sat Nov 9 | vsTBD | W79-54 | 1-1 | .500 | - | | Wolstein Center · Cleveland, OH |
| 3 | Tue Nov 12 | atMissouri St | L53-73 | 1-2 | .333 | - | | Great Southern Bank Arena · Springfield, MO |
| 4 | Fri Nov 15 | atSouth Carolina | L63-90 | 1-3 | .250 | - | | Colonial Life Arena · Columbia, SC |
| 5 | Tue Nov 19 | vsFIU | L61-107 | 1-4 | .200 | - | | Wolstein Center · Cleveland, OH |
| 6 | Fri Nov 22 | atUNC Wilmington | W47-46 | 2-4 | .333 | - | | Trask Coliseum · Wilmington, NC |
| 7 | Sat Nov 23 | vsE Kentucky | W65-51 | 3-4 | .429 | - | | Wolstein Center · Cleveland, OH |
| 8 | Sat Nov 30 | vsRobert Morris | W70-59 | 4-4 | .500 | - | | Wolstein Center · Cleveland, OH |
| 9 | Wed Dec 4 | vsToledo | L65-80 | 4-5 | .444 | - | | Wolstein Center · Cleveland, OH |
| 10 | Sat Dec 7 | atKent State | L59-81 | 4-6 | .400 | - | | M.A.C. Center · Kent, OH |
| 11 | Sun Dec 15 | atBowling Green | L58-72 | 4-7 | .364 | - | | Stroh Center · Bowling Green, OH |
| 12 | Wed Dec 18 | vsDePaul | L65-73 | 4-8 | .333 | - | | Wolstein Center · Cleveland, OH |
| 13 | Sat Dec 21 | atETSU | L55-80 | 4-9 | .308 | - | | Freedom Hall Civic Center · Johnson City, TN |
| 14 | Sat Dec 28 | atUIC | L66-71 | 4-10 | .286 | - | | Credit Union 1 Arena · Chicago, IL |
| 15 | Mon Dec 30 | atIU Indy | W82-80 | 5-10 | .333 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 16 | Sat Jan 4 | vsYoungstown St | W82-74 | 6-10 | .375 | - | | Wolstein Center · Cleveland, OH |
| 17 | Thu Jan 9 | vsDetroit Mercy | W64-59 | 7-10 | .412 | - | | Wolstein Center · Cleveland, OH |
| 18 | Sat Jan 11 | vsOakland | L55-68 | 7-11 | .389 | - | | Wolstein Center · Cleveland, OH |
| 19 | Thu Jan 16 | atWright St | L62-75 | 7-12 | .368 | - | | Nutter Center · Dayton, OH |
| 20 | Sat Jan 18 | atN Kentucky | L49-75 | 7-13 | .350 | - | | Truist Arena · Highland Heights, KY |
| 21 | Thu Jan 23 | vsGreen Bay | L74-78 | 7-14 | .333 | - | | Wolstein Center · Cleveland, OH |
| 22 | Sat Jan 25 | vsMilwaukee | W70-53 | 8-14 | .364 | - | | Wolstein Center · Cleveland, OH |
| 23 | Thu Jan 30 | vsIU Indy | W72-62 | 9-14 | .391 | - | | Wolstein Center · Cleveland, OH |
| 24 | Sat Feb 1 | vsUIC | L62-64 | 9-15 | .375 | - | | Wolstein Center · Cleveland, OH |
| 25 | Sat Feb 8 | atYoungstown St | L55-67 | 9-16 | .360 | - | | Beeghly Center · Youngstown, OH |
| 26 | Thu Feb 13 | atOakland | L74-79 | 9-17 | .346 | - | | Athletics Center O'rena · Rochester, MI |
| 27 | Sat Feb 15 | atDetroit Mercy | W67-66 (OT) | 10-17 | .370 | - | | Calihan Hall · Detroit, MI |
| 28 | Thu Feb 20 | vsN Kentucky | L59-73 | 10-18 | .357 | - | | Wolstein Center · Cleveland, OH |
| 29 | Sat Feb 22 | vsWright St | L74-81 (OT) | 10-19 | .345 | - | | Wolstein Center · Cleveland, OH |
| 30 | Thu Feb 27 | atMilwaukee | W70-68 | 11-19 | .367 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 31 | Sat Feb 29 | atGreen Bay | L67-74 | 11-20 | .355 | - | | Resch Center · Ashwaubenon, WI |
| 32 | Tue Mar 3 | atOakland | L59-80 | 11-21 | .344 | - | | Athletics Center O'rena · Rochester, MI |
