| 1 | Tue Nov 9 | at BYU | L59-69 | 0-1 | .000 | - | | Marriott Center · Provo, UT |
| 2 | Sat Nov 13 | vsOhio | L56-67 | 0-2 | .000 | - | | Wolstein Center · Cleveland, OH |
| 3 | Tue Nov 16 | vsTBD | W75-61 | 1-2 | .333 | - | | Wolstein Center · Cleveland, OH |
| 4 | Sat Nov 20 | vsCanisius | W80-70 | 2-2 | .500 | - | | Wolstein Center · Cleveland, OH |
| 5 | Mon Nov 22 | vsCoppin St | W65-62 | 3-2 | .600 | - | | Wolstein Center · Cleveland, OH |
| 6 | Sat Nov 27 | vsTBD | W89-47 | 4-2 | .667 | - | | Wolstein Center · Cleveland, OH |
| 7 | Thu Dec 2 | vsN Kentucky | W72-58 | 5-2 | .714 | - | | Wolstein Center · Cleveland, OH |
| 8 | Sat Dec 4 | vsWright St | W85-75 | 6-2 | .750 | - | | Wolstein Center · Cleveland, OH |
| 9 | Mon Dec 13 | atOklahoma St | L93-98 (OT) | 6-3 | .667 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 10 | Thu Dec 30 | vsPurdue FW | W90-81 | 7-3 | .700 | - | | Wolstein Center · Cleveland, OH |
| 12 | Wed Jan 5 | vsPurdue FW | W65-58 | 8-3 | .727 | - | | Wolstein Center · Cleveland, OH |
| 13 | Fri Jan 7 | atRobert Morris | W78-77 | 9-3 | .750 | - | | UPMC Events Center · Moon Township, PA |
| 14 | Sun Jan 9 | atYoungstown St | W86-80 (OT) | 10-3 | .769 | - | | Beeghly Center · Youngstown, OH |
| 15 | Thu Jan 13 | vsOakland | L65-70 | 10-4 | .714 | - | | Wolstein Center · Cleveland, OH |
| 16 | Sat Jan 15 | vsDetroit Mercy | W72-70 | 11-4 | .733 | - | | Wolstein Center · Cleveland, OH |
| 17 | Fri Jan 21 | vsYoungstown St | W64-61 | 12-4 | .750 | - | | Wolstein Center · Cleveland, OH |
| 18 | Sun Jan 23 | vsRobert Morris | W75-68 | 13-4 | .765 | - | | Wolstein Center · Cleveland, OH |
| 19 | Fri Jan 28 | atWright St | W71-67 | 14-4 | .778 | - | ESPNU | Nutter Center · Dayton, OH |
| 20 | Sun Jan 30 | atN Kentucky | L72-78 | 14-5 | .737 | - | | Truist Arena · Highland Heights, KY |
| 21 | Fri Feb 4 | vsGreen Bay | W85-69 | 15-5 | .750 | - | | Wolstein Center · Cleveland, OH |
| 22 | Sun Feb 6 | vsMilwaukee | W84-71 | 16-5 | .762 | - | | Wolstein Center · Cleveland, OH |
| 23 | Thu Feb 10 | vsUIC | L75-76 | 16-6 | .727 | - | | Wolstein Center · Cleveland, OH |
| 24 | Sat Feb 12 | vsIU Indy | W83-45 | 17-6 | .739 | - | | Wolstein Center · Cleveland, OH |
| 25 | Mon Feb 14 | atPurdue FW | L98-102 (3OT) | 17-7 | .708 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 26 | Fri Feb 18 | atMilwaukee | W78-61 | 18-7 | .720 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 27 | Sun Feb 20 | atGreen Bay | W79-67 | 19-7 | .731 | - | | Resch Center · Ashwaubenon, WI |
| 28 | Thu Feb 24 | atDetroit Mercy | L67-74 | 19-8 | .704 | - | | Calihan Hall · Detroit, MI |
| 29 | Sat Feb 26 | atOakland | L57-65 | 19-9 | .679 | - | | Athletics Center O'rena · Rochester, MI |
| 30 | Thu Mar 3 | vsRobert Morris | W83-67 | 20-9 | .690 | - | | Wolstein Center · Cleveland, OH |
| 31 | Mon Mar 7 | vsWright St | L67-82 | 20-10 | .667 | - | ESPNU | Indiana Farmers Coliseum · Indianapolis, IN |
| 31 | Tue Mar 15 | atXavier | L68-72 | 20-11 | .645 | - | ESPNU | Cintas Center · Cincinnati, OH |
