| 1 | Wed Nov 6 | at Butler | L47-80 | 0-1 | .000 | - | FS2 | Hinkle Fieldhouse · Indianapolis, IN |
| 2 | Sat Nov 9 | atBradley | L56-90 | 0-2 | .000 | - | | Carver Arena · Peoria, IL |
| 3 | Mon Nov 11 | vsTBD | W72-55 | 1-2 | .333 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 4 | Wed Nov 13 | atSouth Florida | W70-53 | 2-2 | .500 | - | | Yuengling Center · Tampa, FL |
| 5 | Wed Nov 20 | atLoyola Chicago | L62-85 | 2-3 | .400 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 6 | Mon Nov 25 | vsLoyola MD | L77-81 | 2-4 | .333 | - | | Nationwide Arena · Columbus, OH |
| 7 | Tue Nov 26 | vsSouthern | L77-83 | 2-5 | .286 | - | | Nationwide Arena · Columbus, OH |
| 8 | Sat Nov 30 | vsEvansville | L64-70 | 2-6 | .250 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 9 | Wed Dec 4 | atMorehead St | L51-56 | 2-7 | .222 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 10 | Sat Dec 7 | atBall State | L54-102 | 2-8 | .200 | - | | Worthen Arena · Muncie, IN |
| 11 | Tue Dec 10 | vsTBD | W80-60 | 3-8 | .273 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 12 | Sat Dec 14 | vsPurdue FW | W74-65 | 4-8 | .333 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 13 | Fri Dec 20 | atFresno St | L64-95 | 4-9 | .308 | - | | Save Mart Center · Fresno, CA |
| 14 | Sat Dec 28 | vsYoungstown St | L73-83 | 4-10 | .286 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 15 | Mon Dec 30 | vsCleveland St | L80-82 | 4-11 | .267 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 16 | Fri Jan 3 | atMilwaukee | L74-78 | 4-12 | .250 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 17 | Sun Jan 5 | atGreen Bay | W93-78 | 5-12 | .294 | - | | Resch Center · Ashwaubenon, WI |
| 18 | Fri Jan 10 | vsWright St | L70-84 | 5-13 | .278 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 19 | Sun Jan 12 | vsN Kentucky | L71-96 | 5-14 | .263 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 20 | Sat Jan 18 | vsUIC | L66-75 | 5-15 | .250 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 21 | Thu Jan 23 | atDetroit Mercy | L64-76 | 5-16 | .238 | - | | Calihan Hall · Detroit, MI |
| 22 | Sat Jan 25 | atOakland | W89-85 (OT) | 6-16 | .273 | - | | Athletics Center O'rena · Rochester, MI |
| 23 | Thu Jan 30 | atCleveland St | L62-72 | 6-17 | .261 | - | | Wolstein Center · Cleveland, OH |
| 24 | Sat Feb 1 | atYoungstown St | L76-91 | 6-18 | .250 | - | | Beeghly Center · Youngstown, OH |
| 25 | Thu Feb 6 | vsGreen Bay | L85-91 | 6-19 | .240 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 26 | Sat Feb 8 | vsMilwaukee | L79-80 (OT) | 6-20 | .231 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 27 | Fri Feb 14 | atN Kentucky | L70-84 | 6-21 | .222 | - | | Truist Arena · Highland Heights, KY |
| 28 | Sun Feb 16 | atWright St | L66-106 | 6-22 | .214 | - | | Nutter Center · Dayton, OH |
| 29 | Sat Feb 22 | atUIC | L72-77 | 6-23 | .207 | - | | Credit Union 1 Arena · Chicago, IL |
| 30 | Thu Feb 27 | vsOakland | W71-68 | 7-23 | .233 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 31 | Sat Feb 29 | vsDetroit Mercy | L88-90 | 7-24 | .226 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 32 | Tue Mar 3 | atUIC | L59-93 | 7-25 | .219 | - | | Credit Union 1 Arena · Chicago, IL |
