| 1 | Mon Nov 7 | at Iowa State | L39-88 | 0-1 | .000 | - | | James H. Hilton Coliseum · Ames, IA |
| 2 | Wed Nov 9 | atDrake | L48-80 | 0-2 | .000 | - | | The Knapp Center · Des Moines, IA |
| 3 | Mon Nov 14 | atChicago St | L58-68 | 0-3 | .000 | - | | Jones Convocation Center · Chicago, IL |
| 4 | Sat Nov 19 | vsTBD | W59-45 | 1-3 | .250 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 5 | Wed Nov 23 | vsDenver | L64-86 | 1-4 | .200 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 6 | Thu Nov 24 | atNew Orleans | L84-87 | 1-5 | .167 | - | | Lakefront Arena · New Orleans, LA |
| 7 | Fri Nov 25 | atThe Citadel | L53-74 | 1-6 | .143 | - | | McAlister Field House · Charleston, SC |
| 8 | Sat Dec 3 | atMilwaukee | L61-74 | 1-7 | .125 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 9 | Mon Dec 5 | atGreen Bay | L61-68 | 1-8 | .111 | - | | Resch Center · Ashwaubenon, WI |
| 10 | Mon Dec 12 | vsTBD | W75-53 | 2-8 | .200 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 11 | Sat Dec 17 | vsE Illinois | L59-70 | 2-9 | .182 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 12 | Mon Dec 19 | vsSo Indiana | L74-87 | 2-10 | .167 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 13 | Tue Dec 20 | vsE Texas A&M | W62-52 | 3-10 | .231 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 14 | Sat Dec 31 | vsN Kentucky | L42-55 | 3-11 | .214 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 15 | Mon Jan 2 | vsWright St | L68-82 | 3-12 | .200 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 16 | Sat Jan 7 | atYoungstown St | L74-105 | 3-13 | .188 | - | | Beeghly Center · Youngstown, OH |
| 17 | Mon Jan 9 | atRobert Morris | L70-77 | 3-14 | .176 | - | | UPMC Events Center · Moon Township, PA |
| 18 | Thu Jan 12 | vsPurdue FW | L55-70 | 3-15 | .167 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 19 | Sat Jan 14 | vsCleveland St | L54-89 | 3-16 | .158 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 20 | Thu Jan 19 | vsOakland | L77-83 (OT) | 3-17 | .150 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 21 | Sat Jan 21 | vsDetroit Mercy | L77-89 | 3-18 | .143 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 22 | Wed Jan 25 | atPurdue FW | L75-81 | 3-19 | .136 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 23 | Sun Jan 29 | atCleveland St | L72-78 | 3-20 | .130 | - | | Wolstein Center · Cleveland, OH |
| 24 | Thu Feb 2 | vsMilwaukee | L69-72 | 3-21 | .125 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 25 | Sat Feb 4 | vsGreen Bay | W68-53 | 4-21 | .160 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 26 | Wed Feb 8 | atWright St | L71-103 | 4-22 | .154 | - | | Nutter Center · Dayton, OH |
| 27 | Sun Feb 12 | atN Kentucky | L47-86 | 4-23 | .148 | - | | Truist Arena · Highland Heights, KY |
| 28 | Wed Feb 15 | atOakland | L81-85 | 4-24 | .143 | - | | Athletics Center O'rena · Rochester, MI |
| 29 | Sun Feb 19 | atDetroit Mercy | L68-81 | 4-25 | .138 | - | | Calihan Hall · Detroit, MI |
| 30 | Thu Feb 23 | vsRobert Morris | W81-75 | 5-25 | .167 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 31 | Sat Feb 25 | vsYoungstown St | L79-93 | 5-26 | .161 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 32 | Tue Feb 28 | atRobert Morris | L64-67 | 5-27 | .156 | - | | UPMC Events Center · Moon Township, PA |
