| 1 | Mon Nov 4 | vs Binghamton | W108-66 | 1-0 | 1.000 | - | B1G+ | Bryce Jordan Center · University Park, PA |
| 2 | Fri Nov 8 | vsUMBC | W103-54 | 2-0 | 1.000 | - | BTN | Bryce Jordan Center · University Park, PA |
| 3 | Tue Nov 12 | vsSt Francis PA | W92-62 | 3-0 | 1.000 | - | Peacock | Bryce Jordan Center · University Park, PA |
| 4 | Fri Nov 15 | vsVirginia Tech | W86-64 | 4-0 | 1.000 | - | Peacock | Bryce Jordan Center · University Park, PA |
| 5 | Wed Nov 20 | vsPurdue FW | W102-89 | 5-0 | 1.000 | - | B1G+ | Bryce Jordan Center · University Park, PA |
| 6 | Mon Nov 25 | atFordham | W85-66 | 6-0 | 1.000 | - | CBSSN | Rose Hill Gymnasium · Bronx, NY |
| 7 | Tue Nov 26 | vsClemson | L67-75 | 6-1 | .857 | - | CBSSN | Bryce Jordan Center · University Park, PA |
| 8 | Sun Dec 1 | vsBuffalo | W87-64 | 7-1 | .875 | - | BTN | Bryce Jordan Center · University Park, PA |
| 9 | Thu Dec 5 | vs8Purdue | W81-70 | 8-1 | .889 | - | FS1 | Bryce Jordan Center · University Park, PA |
| 10 | Tue Dec 10 | atRutgers | L76-80 | 8-2 | .800 | - | Peacock | Jersey Mike’s Arena · Piscataway, NJ |
| 11 | Sat Dec 14 | vsCoppin St | W99-51 | 9-2 | .818 | - | BTN | Bryce Jordan Center · University Park, PA |
| 12 | Sat Dec 21 | atDrexel | W75-64 | 10-2 | .833 | - | | Xfinity Mobile Arena · Philadelphia, PA |
| 13 | Sun Dec 29 | vsPenn | W86-66 | 11-2 | .846 | - | Peacock | Bryce Jordan Center · University Park, PA |
| 14 | Thu Jan 2 | vsNorthwestern | W84-80 | 12-2 | .857 | - | Peacock | Bryce Jordan Center · University Park, PA |
| 15 | Sun Jan 5 | vsIndiana | L71-77 | 12-3 | .800 | - | BTN | The Palestra · Philadelphia, PA |
| 16 | Wed Jan 8 | at13Illinois | L52-91 | 12-4 | .750 | - | BTN | State Farm Center · Champaign, IL |
| 17 | Sun Jan 12 | vs15Oregon | L81-82 | 12-5 | .706 | - | BTN | Bryce Jordan Center · University Park, PA |
| 18 | Wed Jan 15 | at12Michigan St | L85-90 | 12-6 | .667 | - | BTN | Breslin Center · East Lansing, MI |
| 19 | Mon Jan 20 | vsRutgers | W80-72 | 13-6 | .684 | - | Peacock | Bryce Jordan Center · University Park, PA |
| 20 | Fri Jan 24 | atIowa | L75-76 | 13-7 | .650 | - | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 21 | Mon Jan 27 | atMichigan | L72-76 | 13-8 | .619 | - | BTN | Crisler Center · Ann Arbor, MI |
| 22 | Thu Jan 30 | vsOhio State | L64-83 | 13-9 | .591 | - | FS1 | Bryce Jordan Center · University Park, PA |
| 23 | Tue Feb 4 | vsMinnesota | L61-69 | 13-10 | .565 | - | BTN | Bryce Jordan Center · University Park, PA |
| 24 | Sat Feb 8 | atUCLA | L54-78 | 13-11 | .542 | - | BTN | Pauley Pavilion · Los Angeles, CA |
| 25 | Tue Feb 11 | atUSC | L67-92 | 13-12 | .520 | - | BTN | Galen Center · Los Angeles, CA |
| 26 | Sat Feb 15 | vsWashington | L73-75 | 13-13 | .500 | - | BTN | Bryce Jordan Center · University Park, PA |
| 27 | Wed Feb 19 | vsNebraska | W89-72 | 14-13 | .519 | - | BTN | Bryce Jordan Center · University Park, PA |
| 28 | Sat Feb 22 | atMinnesota | W69-60 | 15-13 | .536 | - | BTN | Williams Arena · Minneapolis, MN |
| 29 | Wed Feb 26 | atIndiana | L78-83 | 15-14 | .517 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 30 | Sat Mar 1 | vs16Maryland | L64-68 | 15-15 | .500 | - | BTN | Bryce Jordan Center · University Park, PA |
| 31 | Sat Mar 8 | at12Wisconsin | W86-75 | 16-15 | .516 | - | Peacock | Kohl Center · Madison, WI |
