| 2 | Sat Nov 28 | vs VMI | W86-65 | 1-0 | 1.000 | - | | Bryce Jordan Center · University Park, PA |
| 3 | Wed Dec 2 | vsVCU | W72-69 | 2-0 | 1.000 | - | FS1 | Bryce Jordan Center · University Park, PA |
| 4 | Sun Dec 6 | vsSeton Hall | L92-98 (OT) | 2-1 | .667 | - | BTN | Bryce Jordan Center · University Park, PA |
| 5 | Tue Dec 8 | atVirginia Tech | W75-55 | 3-1 | .750 | - | ESPNU | Cassell Coliseum · Blacksburg, VA |
| 6 | Sun Dec 13 | atMichigan | L58-62 | 3-2 | .600 | - | BTN | Crisler Center · Ann Arbor, MI |
| 7 | Wed Dec 23 | vs18Illinois | L81-98 | 3-3 | .500 | - | BTN | Bryce Jordan Center · University Park, PA |
| 8 | Wed Dec 30 | atIndiana | L85-87 (OT) | 3-4 | .429 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 9 | Sun Jan 3 | vs6Wisconsin | PPD | 11-14 | .440 | - | | Bryce Jordan Center · University Park, PA |
| 10 | Wed Jan 6 | atOhio State | PPD | 11-14 | .440 | - | BTN | Value City Arena · Columbus, OH |
| 12 | Tue Jan 12 | vsRutgers | PPD | 11-14 | .440 | - | BTN | Bryce Jordan Center · University Park, PA |
| 13 | Sun Jan 17 | atPurdue | L72-80 | 3-5 | .375 | - | | Mackey Arena · West Lafayette, IN |
| 14 | Tue Jan 19 | at22Illinois | L65-79 | 3-6 | .333 | - | BTN | State Farm Center · Champaign, IL |
| 15 | Thu Jan 21 | vsRutgers | W75-67 | 4-6 | .400 | - | BTN | Bryce Jordan Center · University Park, PA |
| 16 | Sat Jan 23 | vsNorthwestern | W81-78 | 5-6 | .455 | - | BTN | Bryce Jordan Center · University Park, PA |
| 17 | Wed Jan 27 | at13Ohio State | L79-83 | 5-7 | .417 | - | BTN | Value City Arena · Columbus, OH |
| 18 | Sat Jan 30 | vs14Wisconsin | W81-71 | 6-7 | .462 | - | BTN | Bryce Jordan Center · University Park, PA |
| 19 | Tue Feb 2 | at19Wisconsin | L56-72 | 6-8 | .429 | - | BTN | Kohl Center · Madison, WI |
| 20 | Fri Feb 5 | vsMaryland | W55-50 | 7-8 | .467 | - | FS1 | Bryce Jordan Center · University Park, PA |
| 21 | Tue Feb 9 | atMichigan St | L58-60 | 7-9 | .438 | - | ESPN2 | Breslin Center · East Lansing, MI |
| 22 | Sun Feb 14 | vsNebraska | L61-62 | 7-10 | .412 | - | BTN | Bryce Jordan Center · University Park, PA |
| 23 | Thu Feb 18 | vs4Ohio State | L82-92 | 7-11 | .389 | - | BTN | Bryce Jordan Center · University Park, PA |
| 24 | Sun Feb 21 | at11Iowa | L68-74 | 7-12 | .368 | - | | Carver-Hawkeye Arena · Iowa City, IA |
| 25 | Tue Feb 23 | atNebraska | W86-83 | 8-12 | .400 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 26 | Fri Feb 26 | vsPurdue | L52-73 | 8-13 | .381 | - | FS1 | Bryce Jordan Center · University Park, PA |
| 27 | Wed Mar 3 | vsMinnesota | W84-65 | 9-13 | .409 | - | BTN | Bryce Jordan Center · University Park, PA |
| 28 | Sun Mar 7 | atMaryland | W66-61 | 10-13 | .435 | - | | XFINITY Center · College Park, MD |
| 29 | Wed Mar 10 | vsNebraska | W72-66 | 11-13 | .458 | - | BTN | Lucas Oil Stadium · Indianapolis, IN |
| 30 | Thu Mar 11 | atWisconsin | L74-75 | 11-14 | .440 | - | BTN | Lucas Oil Stadium · Indianapolis, IN |
