| 1 | Tue Nov 5 | vs MD-Eastern | W84-46 | 1-0 | 1.000 | - | | Bryce Jordan Center · University Park, PA |
| 2 | Sat Nov 9 | vsWagner | W91-64 | 2-0 | 1.000 | - | | Bryce Jordan Center · University Park, PA |
| 3 | Thu Nov 14 | atGeorgetown | W81-66 | 3-0 | 1.000 | - | FS1 | Capital One Arena · Washington, D.C. |
| 4 | Tue Nov 19 | vsBucknell | W98-70 | 4-0 | 1.000 | - | BTN | Bryce Jordan Center · University Park, PA |
| 5 | Sat Nov 23 | vsYale | W58-56 | 5-0 | 1.000 | - | | Bryce Jordan Center · University Park, PA |
| 6 | Wed Nov 27 | vsOle Miss | L72-74 | 5-1 | .833 | - | ESPN2 | Bryce Jordan Center · University Park, PA |
| 7 | Fri Nov 29 | atSyracuse | W85-64 | 6-1 | .857 | - | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 8 | Wed Dec 4 | vsWake Forest | W76-54 | 7-1 | .875 | - | ESPNU | Bryce Jordan Center · University Park, PA |
| 9 | Sat Dec 7 | at6Ohio State | L74-106 | 7-2 | .778 | - | BTN | Value City Arena · Columbus, OH |
| 10 | Tue Dec 10 | vs4Maryland | W76-69 | 8-2 | .800 | - | ESPN2 | Bryce Jordan Center · University Park, PA |
| 11 | Sat Dec 14 | vsAlabama | W73-71 | 9-2 | .818 | - | BTN | Bryce Jordan Center · University Park, PA |
| 12 | Fri Dec 20 | vsC Connecticut | W87-58 | 10-2 | .833 | #23 | BTN | Bryce Jordan Center · University Park, PA |
| 13 | Sun Dec 29 | vsCornell | W90-59 | 11-2 | .846 | #20 | ESPNU | Bryce Jordan Center · University Park, PA |
| 14 | Sat Jan 4 | vs23Iowa | W89-86 | 12-2 | .857 | #21 | BTN | The Palestra · Philadelphia, PA |
| 15 | Tue Jan 7 | atRutgers | L61-72 | 12-3 | .800 | #20 | BTN | Jersey Mike’s Arena · Piscataway, NJ |
| 16 | Sat Jan 11 | vsWisconsin | L49-58 | 12-4 | .750 | #20 | BTN | Bryce Jordan Center · University Park, PA |
| 17 | Wed Jan 15 | atMinnesota | L69-75 | 12-5 | .706 | - | BTN | Williams Arena · Minneapolis, MN |
| 18 | Sat Jan 18 | vs21Ohio State | W90-76 | 13-5 | .722 | - | ESPNU | Bryce Jordan Center · University Park, PA |
| 19 | Wed Jan 22 | atMichigan | W72-63 | 14-5 | .737 | - | BTN | Crisler Center · Ann Arbor, MI |
| 20 | Wed Jan 29 | vsIndiana | W64-49 | 15-5 | .750 | #24 | BTN | Bryce Jordan Center · University Park, PA |
| 21 | Sat Feb 1 | atNebraska | W76-64 | 16-5 | .762 | #24 | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 22 | Tue Feb 4 | at16Michigan St | W75-70 | 17-5 | .773 | #22 | BTN | Breslin Center · East Lansing, MI |
| 23 | Sat Feb 8 | vsMinnesota | W83-77 | 18-5 | .783 | #22 | BTN | Bryce Jordan Center · University Park, PA |
| 24 | Tue Feb 11 | atPurdue | W88-76 | 19-5 | .792 | #13 | BTN | Mackey Arena · West Lafayette, IN |
| 25 | Sat Feb 15 | vsNorthwestern | W77-61 | 20-5 | .800 | #13 | BTN | Bryce Jordan Center · University Park, PA |
| 26 | Tue Feb 18 | vsIllinois | L56-62 | 20-6 | .769 | #9 | FS1 | Bryce Jordan Center · University Park, PA |
| 27 | Sun Feb 23 | atIndiana | L60-68 | 20-7 | .741 | #9 | FS1 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 28 | Wed Feb 26 | vsRutgers | W65-64 | 21-7 | .750 | #16 | BTN | Bryce Jordan Center · University Park, PA |
| 29 | Sat Feb 29 | at18Iowa | L68-77 | 21-8 | .724 | #16 | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 30 | Tue Mar 3 | vs16Michigan St | L71-79 | 21-9 | .700 | #20 | ESPN | Bryce Jordan Center · University Park, PA |
| 31 | Sat Mar 7 | atNorthwestern | L69-80 | 21-10 | .677 | #20 | BTN | Welsh-Ryan Arena · Evanston, IL |
