| 1 | Mon Nov 7 | vs Winthrop | W93-68 | 1-0 | 1.000 | - | | Bryce Jordan Center · University Park, PA |
| 2 | Thu Nov 10 | vsLoyola MD | W90-65 | 2-0 | 1.000 | - | | Bryce Jordan Center · University Park, PA |
| 3 | Mon Nov 14 | vsButler | W68-62 | 3-0 | 1.000 | - | FS1 | Bryce Jordan Center · University Park, PA |
| 4 | Thu Nov 17 | vsFurman | W73-68 | 4-0 | 1.000 | - | ESPNU | TD Arena · Charleston, SC |
| 5 | Fri Nov 18 | atVirginia Tech | L59-61 | 4-1 | .800 | - | ESPN2 | TD Arena · Charleston, SC |
| 6 | Sun Nov 20 | atColorado St | W68-56 | 5-1 | .833 | - | ESPNU | TD Arena · Charleston, SC |
| 7 | Fri Nov 25 | vsLafayette | W70-57 | 6-1 | .857 | - | | Bryce Jordan Center · University Park, PA |
| 8 | Tue Nov 29 | atClemson | L94-101 (2OT) | 6-2 | .750 | - | ESPNU | Littlejohn Coliseum · Clemson, SC |
| 9 | Wed Dec 7 | vsMichigan St | L58-67 | 6-3 | .667 | - | BTN | Bryce Jordan Center · University Park, PA |
| 10 | Sat Dec 10 | at#17Illinois | W74-59 | 7-3 | .700 | - | BTN | State Farm Center · Champaign, IL |
| 11 | Sun Dec 18 | vsCanisius | W97-67 | 8-3 | .727 | - | BTN | Bryce Jordan Center · University Park, PA |
| 12 | Thu Dec 22 | vsQuinnipiac | W77-68 | 9-3 | .750 | - | BTN | Bryce Jordan Center · University Park, PA |
| 13 | Thu Dec 29 | vsDelaware St | W60-46 | 10-3 | .769 | - | | Bryce Jordan Center · University Park, PA |
| 14 | Sun Jan 1 | vsIowa | W83-79 | 11-3 | .786 | - | BTN | Bryce Jordan Center · University Park, PA |
| 15 | Wed Jan 4 | atMichigan | L69-79 | 11-4 | .733 | - | BTN | Crisler Center · Ann Arbor, MI |
| 16 | Sun Jan 8 | vsPurdue | L63-76 | 11-5 | .688 | - | BTN | Bryce Jordan Center · University Park, PA |
| 17 | Wed Jan 11 | vsIndiana | W85-66 | 12-5 | .706 | - | BTN | Bryce Jordan Center · University Park, PA |
| 18 | Tue Jan 17 | atWisconsin | L60-63 | 12-6 | .667 | - | BTN | Kohl Center · Madison, WI |
| 19 | Sat Jan 21 | vsNebraska | W76-65 | 13-6 | .684 | - | BTN | Bryce Jordan Center · University Park, PA |
| 20 | Tue Jan 24 | atRutgers | L45-65 | 13-7 | .650 | - | BTN | Jersey Mike’s Arena · Piscataway, NJ |
| 21 | Sun Jan 29 | vsMichigan | W83-61 | 14-7 | .667 | - | BTN | Bryce Jordan Center · University Park, PA |
| 22 | Wed Feb 1 | at#1Purdue | L60-80 | 14-8 | .636 | - | BTN | Mackey Arena · West Lafayette, IN |
| 23 | Sun Feb 5 | atNebraska | L63-72 | 14-9 | .609 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 24 | Wed Feb 8 | vsWisconsin | L74-79 (OT) | 14-10 | .583 | - | BTN | Bryce Jordan Center · University Park, PA |
| 25 | Sat Feb 11 | atMaryland | L68-74 | 14-11 | .560 | - | BTN | XFINITY Center · College Park, MD |
| 26 | Tue Feb 14 | vsIllinois | W93-81 | 15-11 | .577 | - | ESPNU | Bryce Jordan Center · University Park, PA |
| 27 | Sat Feb 18 | atMinnesota | W76-69 | 16-11 | .593 | - | BTN | Williams Arena · Minneapolis, MN |
| 28 | Thu Feb 23 | atOhio State | W75-71 | 17-11 | .607 | - | FS1 | Value City Arena · Columbus, OH |
| 29 | Sun Feb 26 | vsRutgers | L56-59 | 17-12 | .586 | - | BTN | Bryce Jordan Center · University Park, PA |
| 30 | Wed Mar 1 | atNorthwestern | W68-65 (OT) | 18-12 | .600 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 31 | Sun Mar 5 | vs#21Maryland | W65-64 | 19-12 | .613 | - | BTN | Bryce Jordan Center · University Park, PA |
| 32 | Thu Mar 9 | atIllinois | W79-76 | 20-12 | .625 | - | BTN | State Farm Center · Champaign, IL |
| 33 | Fri Mar 10 | atNorthwestern | W67-65 (OT) | 21-12 | .636 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 34 | Sat Mar 11 | atIndiana | W77-73 | 22-12 | .647 | - | CBS | Simon Skjodt Assembly Hall · Bloomington, IN |
| 35 | Sun Mar 12 | atPurdue | L65-67 | 22-13 | .629 | - | CBS | Mackey Arena · West Lafayette, IN |
| 36 | Thu Mar 16 | at#7Texas A&M | W76-59 | 23-13 | .639 | #10 | TBS | Reed Arena · College Station, TX |
| 37 | Sat Mar 18 | at#2Texas | L66-71 | 23-14 | .622 | #10 | CBS | Moody Center · Austin, TX |
