| 1 | Mon Nov 6 | vs Delaware St | W79-45 | 1-0 | 1.000 | - | | Bryce Jordan Center · University Park, PA |
| 2 | Fri Nov 10 | vs Lehigh | W74-65 | 2-0 | 1.000 | - | | Bryce Jordan Center · University Park, PA |
| 3 | Tue Nov 14 | vs St Francis PA | W83-53 | 3-0 | 1.000 | - | BTN | Bryce Jordan Center · University Park, PA |
| 4 | Fri Nov 17 | vs Morehead St | W74-51 | 4-0 | 1.000 | - | | Bryce Jordan Center · University Park, PA |
| 5 | Thu Nov 23 | at #12Texas A&M | L77-89 | 4-1 | .800 | - | ESPN | Reed Arena · College Station, TX |
| 6 | Fri Nov 24 | at Butler | L78-88 | 4-2 | .667 | - | | Hinkle Fieldhouse · Indianapolis, IN |
| 7 | Sun Nov 26 | at VCU | L74-86 | 4-3 | .571 | - | ESPNU | Stuart C. Siegel Center · Richmond, VA |
| 8 | Sat Dec 2 | vs Bucknell | L67-76 | 4-4 | .500 | - | BTN | Bryce Jordan Center · University Park, PA |
| 9 | Wed Dec 6 | at Maryland | L75-81 (OT) | 4-5 | .444 | - | BTN | XFINITY Center · College Park, MD |
| 10 | Sat Dec 9 | vs Ohio State | W83-80 | 5-5 | .500 | - | BTN | Bryce Jordan Center · University Park, PA |
| 11 | Sat Dec 16 | vs Georgia Tech | L81-82 (OT) | 5-6 | .455 | - | BTN | Bryce Jordan Center · University Park, PA |
| 12 | Thu Dec 21 | vs Le Moyne | W72-55 | 6-6 | .500 | - | | Bryce Jordan Center · University Park, PA |
| 13 | Fri Dec 29 | vs Rider | W90-63 | 7-6 | .538 | - | | Bryce Jordan Center · University Park, PA |
| 14 | Thu Jan 4 | at Michigan St | L61-92 | 7-7 | .500 | - | | Breslin Center · East Lansing, MI |
| 15 | Sun Jan 7 | vs Michigan | W79-73 | 8-7 | .533 | - | BTN | Bryce Jordan Center · University Park, PA |
| 16 | Wed Jan 10 | vs Northwestern | L72-76 | 8-8 | .500 | - | BTN | Bryce Jordan Center · University Park, PA |
| 17 | Sat Jan 13 | at #1Purdue | L78-95 | 8-9 | .471 | - | BTN | Mackey Arena · West Lafayette, IN |
| 18 | Tue Jan 16 | vs #11Wisconsin | W87-83 | 9-9 | .500 | - | BTN | Bryce Jordan Center · University Park, PA |
| 19 | Sat Jan 20 | atOhio State | L67-79 | 9-10 | .474 | - | BTN | Value City Arena · Columbus, OH |
| 20 | Sat Jan 27 | vs Minnesota | L74-83 | 9-11 | .450 | - | BTN | Bryce Jordan Center · University Park, PA |
| 21 | Wed Jan 31 | at Rutgers | W61-46 | 10-11 | .476 | - | BTN | Jersey Mike’s Arena · Piscataway, NJ |
| 22 | Sat Feb 3 | at Indiana | W85-71 | 11-11 | .500 | - | FS1 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 23 | Thu Feb 8 | vs Iowa | W89-79 | 12-11 | .522 | - | BTN | Bryce Jordan Center · University Park, PA |
| 24 | Sun Feb 11 | atNorthwestern | L63-68 | 12-12 | .500 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 25 | Wed Feb 14 | vsMichigan St | L72-80 | 12-13 | .480 | - | BTN | Bryce Jordan Center · University Park, PA |
| 26 | Sat Feb 17 | at Nebraska | L49-68 | 12-14 | .462 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 27 | Wed Feb 21 | vs #12Illinois | W90-89 | 13-14 | .481 | - | BTN | Bryce Jordan Center · University Park, PA |
| 28 | Sat Feb 24 | vsIndiana | W83-74 | 14-14 | .500 | - | BTN | Bryce Jordan Center · University Park, PA |
| 29 | Tue Feb 27 | atIowa | L81-90 | 14-15 | .483 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 30 | Sat Mar 2 | atMinnesota | L70-75 | 14-16 | .467 | - | BTN | Williams Arena · Minneapolis, MN |
| 31 | Sun Mar 10 | vsMaryland | W85-69 | 15-16 | .484 | - | BTN | Bryce Jordan Center · University Park, PA |
| 32 | Wed Mar 13 | vsMichigan | W66-57 | 16-16 | .500 | - | | Bryce Jordan Center · University Park, PA |
| 33 | Thu Mar 14 | atIndiana | L59-61 | 16-17 | .485 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
