| 1 | Mon Nov 3 | vs Fairfield | 7:00 PM | 12-20 | .375 | - | B1G+ | Bryce Jordan Center · University Park, PA |
| 2 | Sat Nov 8 | atNew Haven | 1:00 PM | 0-0 | .000 | - | | Jeffery P. Hazell Athletics Center |
| 3 | Tue Nov 11 | vsNavy | 6:30 PM | 15-19 | .441 | - | BTN | Bryce Jordan Center · University Park, PA |
| 4 | Sat Nov 15 | atLa Salle | 1:00 PM | 14-19 | .424 | - | Peacock | Tom Gola Arena · Philadelphia, PA |
| 5 | Wed Nov 19 | vsHarvard | 6:30 PM | 12-15 | .444 | - | B1G+ | Bryce Jordan Center · University Park, PA |
| 6 | Sat Nov 22 | vsProvidence | 4:00 PM | 12-20 | .375 | - | truTV | Bryce Jordan Center · University Park, PA |
| 7 | Tue Nov 25 | vsBoston Univ | 7:00 PM | 16-16 | .500 | - | Peacock | Bryce Jordan Center · University Park, PA |
| 8 | Sat Nov 29 | vsSacred Heart | 6:00 PM | 15-18 | .455 | - | Peacock | Bryce Jordan Center · University Park, PA |
| 9 | Tue Dec 2 | vsCampbell | 6:00 PM | 15-17 | .469 | - | BTN | Bryce Jordan Center · University Park, PA |
| 10 | Tue Dec 9 | atIndiana | 8:30 PM | 19-13 | .594 | - | FS1 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 11 | Sat Dec 13 | vs#22Michigan St | 12:00 PM | 30-7 | .811 | - | BTN | Bryce Jordan Center · University Park, PA |
| 12 | Sun Dec 21 | vsPitt | 12:00 PM | 17-15 | .531 | - | BTN | Bryce Jordan Center · University Park, PA |
| 13 | Mon Dec 29 | vsNC Central | 1:00 PM | 14-19 | .424 | - | BTN | Bryce Jordan Center · University Park, PA |
| 14 | Sat Jan 3 | vs#17Illinois | 7:00 PM | 22-13 | .629 | - | BTN | Bryce Jordan Center · University Park, PA |
| 15 | Tue Jan 6 | vs#7Michigan | 7:00 PM | 27-10 | .730 | - | FS1 | Bryce Jordan Center · University Park, PA |
| 16 | Sat Jan 10 | at#1Purdue | 2:00 PM | 24-12 | .667 | - | BTN | Mackey Arena · West Lafayette, IN |
| 17 | Wed Jan 14 | vs#12UCLA | 8:30 PM | 23-11 | .676 | - | FS1 | Bryce Jordan Center · University Park, PA |
| 18 | Sun Jan 18 | atMaryland | 12:00 PM | 27-9 | .750 | - | BTN | XFINITY Center · College Park, MD |
| 19 | Thu Jan 22 | vs#24Wisconsin | 7:00 PM | 27-10 | .730 | - | FS1 | Bryce Jordan Center · University Park, PA |
| 20 | Mon Jan 26 | atOhio State | 7:00 PM | 17-15 | .531 | - | FS1 | Value City Arena · Columbus, OH |
| 21 | Thu Jan 29 | atNorthwestern | 8:00 PM | 17-16 | .515 | - | Peacock | Welsh-Ryan Arena · Evanston, IL |
| 22 | Sun Feb 1 | vsMinnesota | 2:00 PM | 15-17 | .469 | - | Peacock | Bryce Jordan Center · University Park, PA |
| 23 | Thu Feb 5 | at#7Michigan | 6:30 PM | 27-10 | .730 | - | FS1 | Crisler Center · Ann Arbor, MI |
| 24 | Sun Feb 8 | vsUSC | 12:00 PM | 17-18 | .486 | - | BTN | Bryce Jordan Center · University Park, PA |
| 25 | Wed Feb 11 | atWashington | 10:30 PM | 13-18 | .419 | - | BTN | Alaska Airlines Arena · Seattle, WA |
| 26 | Sat Feb 14 | atOregon | 3:00 PM | 25-10 | .714 | - | BTN | Matthew Knight Arena · Eugene, OR |
| 27 | Wed Feb 18 | vsRutgers | 6:00 PM | 15-17 | .469 | - | BTN | Bryce Jordan Center · University Park, PA |
| 28 | Sat Feb 21 | atNebraska | 2:00 PM | 21-14 | .600 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 29 | Sat Feb 28 | vsIowa | 12:00 PM | 17-16 | .515 | - | BTN | Bryce Jordan Center · University Park, PA |
| 30 | Wed Mar 4 | vsOhio State | 7:30 PM | 17-15 | .531 | - | Peacock | Bryce Jordan Center · University Park, PA |
| 31 | Sun Mar 8 | atRutgers | 12:00 PM | 15-17 | .469 | - | BTN | Jersey Mike’s Arena · Piscataway, NJ |
