| 1 | Tue Nov 9 | vs Bellarmine | W96-67 | 1-0 | 1.000 | #7 | | Mackey Arena · West Lafayette, IN |
| 2 | Fri Nov 12 | vsIndiana St | W92-67 | 2-0 | 1.000 | #7 | BTN | Mackey Arena · West Lafayette, IN |
| 3 | Tue Nov 16 | vsWright St | W96-52 | 3-0 | 1.000 | #6 | BTN | Mackey Arena · West Lafayette, IN |
| 4 | Sat Nov 20 | atUNC | W93-84 | 4-0 | 1.000 | - | ESPNEWS | Dean E. Smith Center · Chapel Hill, NC |
| 5 | Sun Nov 21 | vsVillanova | W80-74 | 5-0 | 1.000 | - | ABC | Mackey Arena · West Lafayette, IN |
| 6 | Fri Nov 26 | vsOmaha | W97-40 | 6-0 | 1.000 | #3 | | Mackey Arena · West Lafayette, IN |
| 7 | Tue Nov 30 | vsFlorida St | W93-65 | 7-0 | 1.000 | - | ESPN | Mackey Arena · West Lafayette, IN |
| 8 | Fri Dec 3 | vsIowa | W77-70 | 8-0 | 1.000 | #2 | BTN | Mackey Arena · West Lafayette, IN |
| 9 | Thu Dec 9 | atRutgers | L68-70 | 8-1 | .889 | #1 | BTN | Jersey Mike’s Arena · Piscataway, NJ |
| 10 | Sun Dec 12 | atNC State | W82-72 (OT) | 9-1 | .900 | - | BTN | PNC Arena · Raleigh, NC |
| 11 | Sat Dec 18 | atButler | W77-48 | 10-1 | .909 | - | FOX | Hinkle Fieldhouse · Indianapolis, IN |
| 12 | Mon Dec 20 | vsIncarnate Word | W79-59 | 11-1 | .917 | #3 | BTN | Mackey Arena · West Lafayette, IN |
| 13 | Wed Dec 29 | vsNicholls | W104-90 | 12-1 | .923 | #3 | BTN | Mackey Arena · West Lafayette, IN |
| 14 | Mon Jan 3 | vs23Wisconsin | L69-74 | 12-2 | .857 | #3 | BTN | Mackey Arena · West Lafayette, IN |
| 15 | Sat Jan 8 | atPenn State | W74-67 | 13-2 | .867 | #3 | BTN | Bryce Jordan Center · University Park, PA |
| 16 | Tue Jan 11 | atMichigan | PPD | 29-8 | .784 | #7 | | Crisler Center · Ann Arbor, MI |
| 17 | Fri Jan 14 | vsNebraska | W92-65 | 14-2 | .875 | #7 | FS1 | Mackey Arena · West Lafayette, IN |
| 18 | Mon Jan 17 | at17Illinois | W96-88 (2OT) | 15-2 | .882 | #4 | FOX | State Farm Center · Champaign, IL |
| 19 | Thu Jan 20 | atIndiana | L65-68 | 15-3 | .833 | #4 | FS1 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 20 | Sun Jan 23 | vsNorthwestern | W80-60 | 16-3 | .842 | #4 | BTN | Mackey Arena · West Lafayette, IN |
| 21 | Thu Jan 27 | atIowa | W83-73 | 17-3 | .850 | #6 | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 22 | Sun Jan 30 | vs16Ohio State | W81-78 | 18-3 | .857 | #6 | CBS | Mackey Arena · West Lafayette, IN |
| 23 | Wed Feb 2 | atMinnesota | W88-73 | 19-3 | .864 | #4 | BTN | Williams Arena · Minneapolis, MN |
| 24 | Sat Feb 5 | vsMichigan | W82-76 | 20-3 | .870 | #4 | FOX | Mackey Arena · West Lafayette, IN |
| 25 | Tue Feb 8 | vs13Illinois | W84-68 | 21-3 | .875 | #3 | ESPN | Mackey Arena · West Lafayette, IN |
| 26 | Thu Feb 10 | atMichigan | L58-82 | 21-4 | .840 | #3 | ESPN | Crisler Center · Ann Arbor, MI |
| 27 | Sun Feb 13 | vsMaryland | W62-61 | 22-4 | .846 | #3 | CBS | Mackey Arena · West Lafayette, IN |
| 28 | Wed Feb 16 | atNorthwestern | W70-64 | 23-4 | .852 | #5 | BTN | Welsh-Ryan Arena · Evanston, IL |
| 29 | Sun Feb 20 | vsRutgers | W84-72 | 24-4 | .857 | #5 | FS1 | Mackey Arena · West Lafayette, IN |
| 30 | Sat Feb 26 | atMichigan St | L65-68 | 24-5 | .828 | #4 | ESPN | Breslin Center · East Lansing, MI |
| 31 | Tue Mar 1 | at10Wisconsin | L67-70 | 24-6 | .800 | #8 | ESPN | Kohl Center · Madison, WI |
| 32 | Sat Mar 5 | vsIndiana | W69-67 | 25-6 | .806 | #8 | ESPN | Mackey Arena · West Lafayette, IN |
| 33 | Fri Mar 11 | vsPenn State | W69-61 | 26-6 | .813 | - | BTN | Mackey Arena · West Lafayette, IN |
| 34 | Sat Mar 12 | vsMichigan St | W75-70 | 27-6 | .818 | - | CBS | Mackey Arena · West Lafayette, IN |
| 35 | Sun Mar 13 | vsIowa | L66-75 | 27-7 | .794 | - | CBS | Mackey Arena · West Lafayette, IN |
| 36 | Fri Mar 18 | vs14Yale | W78-56 | 28-7 | .800 | #3 | TBS | Fiserv Forum · Milwaukee, WI |
| 37 | Sun Mar 20 | vs6Texas | W81-71 | 29-7 | .806 | #3 | TNT | Fiserv Forum · Milwaukee, WI |
| 38 | Fri Mar 25 | vs15Saint Peter's | L64-67 | 29-8 | .784 | #3 | CBS | Xfinity Mobile Arena · Philadelphia, PA |
