| 1 | Wed Nov 6 | vs Green Bay | W79-57 | 1-0 | 1.000 | #23 | BTN | Mackey Arena · West Lafayette, IN |
| 2 | Sat Nov 9 | vsTexas | L66-70 | 1-1 | .500 | #23 | FS1 | Mackey Arena · West Lafayette, IN |
| 3 | Wed Nov 13 | atMarquette | L55-65 | 1-2 | .333 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 4 | Sat Nov 16 | vsChicago St | W93-49 | 2-2 | .500 | - | | Mackey Arena · West Lafayette, IN |
| 5 | Sat Nov 23 | vsJ'Ville St | W81-49 | 3-2 | .600 | - | BTN | Mackey Arena · West Lafayette, IN |
| 6 | Fri Nov 29 | vsVCU | W59-56 | 4-2 | .667 | - | CBSSN | Mackey Arena · West Lafayette, IN |
| 7 | Sat Nov 30 | vsFlorida St | L60-63 (OT) | 4-3 | .571 | - | | Mackey Arena · West Lafayette, IN |
| 8 | Wed Dec 4 | vsVirginia | W69-40 | 5-3 | .625 | - | | Mackey Arena · West Lafayette, IN |
| 9 | Sun Dec 8 | vsNorthwestern | W58-44 | 6-3 | .667 | - | BTN | Mackey Arena · West Lafayette, IN |
| 10 | Sun Dec 15 | atNebraska | L56-70 | 6-4 | .600 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 11 | Tue Dec 17 | atOhio | W69-51 | 7-4 | .636 | - | ESPN2 | Convocation Center (OH) · Athens, OH |
| 12 | Sat Dec 21 | vsButler | L61-70 | 7-5 | .583 | - | BTN | Mackey Arena · West Lafayette, IN |
| 13 | Sat Dec 28 | vsC Michigan | W97-62 | 8-5 | .615 | - | BTN | Mackey Arena · West Lafayette, IN |
| 14 | Thu Jan 2 | vsMinnesota | W83-78 (2OT) | 9-5 | .643 | - | BTN | Mackey Arena · West Lafayette, IN |
| 15 | Sun Jan 5 | atIllinois | L37-63 | 9-6 | .600 | - | FS1 | State Farm Center · Champaign, IL |
| 16 | Thu Jan 9 | at19Michigan | L78-84 (2OT) | 9-7 | .563 | - | FS1 | Crisler Center · Ann Arbor, MI |
| 17 | Sun Jan 12 | vs8Michigan St | W71-42 | 10-7 | .588 | - | CBS | Mackey Arena · West Lafayette, IN |
| 18 | Sat Jan 18 | at17Maryland | L50-57 | 10-8 | .556 | - | ESPN2 | XFINITY Center · College Park, MD |
| 19 | Tue Jan 21 | vs21Illinois | L62-79 | 10-9 | .526 | - | ESPNU | Mackey Arena · West Lafayette, IN |
| 20 | Fri Jan 24 | vsWisconsin | W70-51 | 11-9 | .550 | - | FS1 | Mackey Arena · West Lafayette, IN |
| 21 | Tue Jan 28 | at25Rutgers | L63-70 | 11-10 | .524 | - | BTN | Jersey Mike’s Arena · Piscataway, NJ |
| 22 | Sat Feb 1 | atNorthwestern | W61-58 | 12-10 | .545 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 23 | Wed Feb 5 | vs17Iowa | W104-68 | 13-10 | .565 | - | BTN | Mackey Arena · West Lafayette, IN |
| 24 | Sat Feb 8 | atIndiana | W74-62 | 14-10 | .583 | - | ESPN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 25 | Tue Feb 11 | vs13Penn State | L76-88 | 14-11 | .560 | - | BTN | Mackey Arena · West Lafayette, IN |
| 26 | Sat Feb 15 | atOhio State | L52-68 | 14-12 | .538 | - | FOX | Value City Arena · Columbus, OH |
| 27 | Tue Feb 18 | atWisconsin | L65-69 | 14-13 | .519 | - | ESPN | Kohl Center · Madison, WI |
| 28 | Sat Feb 22 | vsMichigan | L63-71 | 14-14 | .500 | - | ESPN | Mackey Arena · West Lafayette, IN |
| 29 | Thu Feb 27 | vsIndiana | W57-49 | 15-14 | .517 | - | FS1 | Mackey Arena · West Lafayette, IN |
| 30 | Tue Mar 3 | at18Iowa | W77-68 | 16-14 | .533 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 31 | Sat Mar 7 | vsRutgers | L68-71 (OT) | 16-15 | .516 | - | BTN | Mackey Arena · West Lafayette, IN |
