| 1 | Tue Nov 4 | vs Evansville | TBD | 11-21 | .344 | #1 | BTN | Mackey Arena · West Lafayette, IN |
| 2 | Fri Nov 7 | vsOakland | TBD | 16-18 | .471 | #1 | Peacock | Mackey Arena · West Lafayette, IN |
| 3 | Thu Nov 13 | at#15Alabama | 7:00 PM | 28-9 | .757 | #1 | ESPN2 | Coleman Coliseum · Tuscaloosa, AL |
| 4 | Sun Nov 16 | vsAkron | TBD | 28-7 | .800 | #1 | | Mackey Arena · West Lafayette, IN |
| 5 | Thu Nov 20 | vsMemphis | 6:00 PM | 29-6 | .829 | #1 | | Mackey Arena · West Lafayette, IN |
| 6 | Fri Nov 28 | vsE Illinois | TBD | 12-19 | .387 | #1 | | Mackey Arena · West Lafayette, IN |
| 7 | Tue Dec 2 | atRutgers | TBD | 15-17 | .469 | #1 | | Jersey Mike’s Arena · Piscataway, NJ |
| 8 | Sat Dec 6 | vs#16Iowa State | 12:00 PM | 25-10 | .714 | #1 | CBS | Mackey Arena · West Lafayette, IN |
| 9 | Wed Dec 10 | vsMinnesota | TBD | 15-17 | .469 | #1 | | Mackey Arena · West Lafayette, IN |
| 10 | Sat Dec 13 | vsMarquette | TBD | 23-11 | .676 | #1 | | Mackey Arena · West Lafayette, IN |
| 11 | Sat Dec 20 | vs#20Auburn | 6:30 PM | 32-6 | .842 | #1 | | Mackey Arena · West Lafayette, IN |
| 12 | Mon Dec 29 | vsKent State | TBD | 24-12 | .667 | #1 | | Mackey Arena · West Lafayette, IN |
| 13 | Sat Jan 3 | at#24Wisconsin | TBD | 27-10 | .730 | #1 | | Kohl Center · Madison, WI |
| 14 | Wed Jan 7 | vsWashington | TBD | 13-18 | .419 | #1 | | Mackey Arena · West Lafayette, IN |
| 15 | Sat Jan 10 | vsPenn State | 2:00 PM | 16-15 | .516 | #1 | BTN | Mackey Arena · West Lafayette, IN |
| 16 | Wed Jan 14 | vsIowa | TBD | 17-16 | .515 | #1 | | Mackey Arena · West Lafayette, IN |
| 17 | Sat Jan 17 | atUSC | 6:00 PM | 17-18 | .486 | #1 | | Galen Center · Los Angeles, CA |
| 18 | Tue Jan 20 | at#12UCLA | 10:00 PM | 23-11 | .676 | #1 | | Pauley Pavilion · Los Angeles, CA |
| 19 | Sat Jan 24 | vs#17Illinois | TBD | 22-13 | .629 | #1 | | Mackey Arena · West Lafayette, IN |
| 20 | Tue Jan 27 | atIndiana | TBD | 19-13 | .594 | #1 | | Simon Skjodt Assembly Hall · Bloomington, IN |
| 21 | Sun Feb 1 | atMaryland | TBD | 27-9 | .750 | #1 | | XFINITY Center · College Park, MD |
| 22 | Sat Feb 7 | vsOregon | TBD | 25-10 | .714 | #1 | | Mackey Arena · West Lafayette, IN |
| 23 | Tue Feb 10 | atNebraska | 7:00 PM | 21-14 | .600 | #1 | FS1 | Pinnacle Bank Arena · Lincoln, NE |
| 24 | Sat Feb 14 | atIowa | TBD | 17-16 | .515 | #1 | | Carver-Hawkeye Arena · Iowa City, IA |
| 25 | Tue Feb 17 | vs#7Michigan | TBD | 27-10 | .730 | #1 | | Mackey Arena · West Lafayette, IN |
| 26 | Fri Feb 20 | vsIndiana | TBD | 19-13 | .594 | #1 | | Mackey Arena · West Lafayette, IN |
| 27 | Thu Feb 26 | vs#22Michigan St | TBD | 30-7 | .811 | #1 | | Mackey Arena · West Lafayette, IN |
| 28 | Sun Mar 1 | atOhio State | TBD | 17-15 | .531 | #1 | | Value City Arena · Columbus, OH |
| 29 | Wed Mar 4 | atNorthwestern | TBD | 17-16 | .515 | #1 | | Welsh-Ryan Arena · Evanston, IL |
| 30 | Sat Mar 7 | vs#24Wisconsin | TBD | 27-10 | .730 | #1 | | Mackey Arena · West Lafayette, IN |
