| 1 | Tue Nov 4 | vs Evansville | W82-51 | 1-0 | 1.000 | #1 | BTN | Mackey Arena · West Lafayette, IN |
| 2 | Fri Nov 7 | vsOakland | W87-77 | 2-0 | 1.000 | #1 | Peacock | Mackey Arena · West Lafayette, IN |
| 3 | Thu Nov 13 | at8Alabama | W87-80 | 3-0 | 1.000 | #2 | ESPN2 | Coleman Coliseum · Tuscaloosa, AL |
| 4 | Sun Nov 16 | vsAkron | W97-79 | 4-0 | 1.000 | #2 | BTN | Mackey Arena · West Lafayette, IN |
| 5 | Thu Nov 20 | vsMemphis | W80-71 | 5-0 | 1.000 | #1 | CBSSN | Mackey Arena · West Lafayette, IN |
| 6 | Fri Nov 21 | vs15Texas Tech | W86-56 | 6-0 | 1.000 | #1 | CBSSN | Mackey Arena · West Lafayette, IN |
| 7 | Fri Nov 28 | vsE Illinois | W109-62 | 7-0 | 1.000 | #1 | BTN | Mackey Arena · West Lafayette, IN |
| 8 | Tue Dec 2 | atRutgers | W81-65 | 8-0 | 1.000 | #1 | FS1 | Jersey Mike’s Arena · Piscataway, NJ |
| 9 | Sat Dec 6 | vs10Iowa State | L58-81 | 8-1 | .889 | #1 | CBS | Mackey Arena · West Lafayette, IN |
| 10 | Wed Dec 10 | vsMinnesota | W85-57 | 9-1 | .900 | #6 | BTN | Mackey Arena · West Lafayette, IN |
| 11 | Sat Dec 13 | vsMarquette | W79-59 | 10-1 | .909 | #6 | Peacock | Mackey Arena · West Lafayette, IN |
| 12 | Sat Dec 20 | vs21Auburn | W88-60 | 11-1 | .917 | #6 | Peacock | Mackey Arena · West Lafayette, IN |
| 13 | Mon Dec 29 | vsKent State | W101-60 | 12-1 | .923 | #5 | B1G+ | Mackey Arena · West Lafayette, IN |
| 14 | Sat Jan 3 | atWisconsin | W89-73 | 13-1 | .929 | #5 | FOX | Kohl Center · Madison, WI |
| 15 | Wed Jan 7 | vsWashington | W81-73 | 14-1 | .933 | #5 | BTN | Mackey Arena · West Lafayette, IN |
| 16 | Sat Jan 10 | vsPenn State | W93-85 | 15-1 | .938 | #5 | BTN | Mackey Arena · West Lafayette, IN |
| 17 | Wed Jan 14 | vsIowa | W79-72 | 16-1 | .941 | #5 | BTN | Mackey Arena · West Lafayette, IN |
| 18 | Sat Jan 17 | atUSC | W69-64 | 17-1 | .944 | #5 | Peacock | Galen Center · Los Angeles, CA |
| 19 | Tue Jan 20 | atUCLA | L67-69 | 17-2 | .895 | #4 | Peacock | Pauley Pavilion · Los Angeles, CA |
| 20 | Sat Jan 24 | vs11Illinois | L82-88 | 17-3 | .850 | #4 | FOX | Mackey Arena · West Lafayette, IN |
| 21 | Tue Jan 27 | atIndiana | L67-72 | 17-4 | .810 | #12 | Peacock | Simon Skjodt Assembly Hall · Bloomington, IN |
| 22 | Sun Feb 1 | atMaryland | W93-63 | 18-4 | .818 | #12 | CBS | XFINITY Center · College Park, MD |
| 23 | Sat Feb 7 | vsOregon | W68-64 | 19-4 | .826 | #12 | CBS | Mackey Arena · West Lafayette, IN |
| 24 | Tue Feb 10 | at7Nebraska | W80-77 (OT) | 20-4 | .833 | #13 | FS1 | Pinnacle Bank Arena · Lincoln, NE |
| 25 | Sat Feb 14 | atIowa | W78-57 | 21-4 | .840 | #13 | FOX | Carver-Hawkeye Arena · Iowa City, IA |
| 26 | Tue Feb 17 | vs1Michigan | L80-91 | 21-5 | .808 | #7 | Peacock | Mackey Arena · West Lafayette, IN |
| 27 | Fri Feb 20 | vsIndiana | W93-64 | 22-5 | .815 | #7 | FOX | Mackey Arena · West Lafayette, IN |
| 28 | Thu Feb 26 | vs13Michigan St | L74-76 | 22-6 | .786 | #8 | Peacock | Mackey Arena · West Lafayette, IN |
| 29 | Sun Mar 1 | atOhio State | L74-82 | 22-7 | .759 | #8 | CBS | Value City Arena · Columbus, OH |
