| 9 | Sat Dec 6 | vs #10Iowa State | 12:00 PM | 8-0 | 1.000 | #1 | CBS | Mackey Arena · West Lafayette, IN |
| 10 | Wed Dec 10 | vsMinnesota | 7:00 PM | 5-4 | .556 | #1 | BTN | Mackey Arena · West Lafayette, IN |
| 11 | Sat Dec 13 | vsMarquette | 2:00 PM | 5-4 | .556 | #1 | Peacock | Mackey Arena · West Lafayette, IN |
| 12 | Sat Dec 20 | vs#20Auburn | 6:30 PM | 7-2 | .778 | #1 | Peacock | Mackey Arena · West Lafayette, IN |
| 13 | Mon Dec 29 | vsKent State | 7:00 PM | 8-1 | .889 | #1 | B1G+ | Mackey Arena · West Lafayette, IN |
| 14 | Sat Jan 3 | atWisconsin | 8:00 PM | 6-2 | .750 | #1 | FOX | Kohl Center · Madison, WI |
| 15 | Wed Jan 7 | vsWashington | 8:30 PM | 5-3 | .625 | #1 | | Mackey Arena · West Lafayette, IN |
| 16 | Sat Jan 10 | vsPenn State | 2:00 PM | 8-1 | .889 | #1 | BTN | Mackey Arena · West Lafayette, IN |
| 17 | Wed Jan 14 | vsIowa | 6:30 PM | 7-1 | .875 | #1 | | Mackey Arena · West Lafayette, IN |
| 18 | Sat Jan 17 | at#24USC | 6:00 PM | 8-0 | 1.000 | #1 | | Galen Center · Los Angeles, CA |
| 19 | Tue Jan 20 | atUCLA | 10:00 PM | 6-2 | .750 | #1 | | Pauley Pavilion · Los Angeles, CA |
| 20 | Sat Jan 24 | vs#14Illinois | 3:00 PM | 6-2 | .750 | #1 | | Mackey Arena · West Lafayette, IN |
| 21 | Tue Jan 27 | at#22Indiana | 9:00 PM | 7-1 | .875 | #1 | | Simon Skjodt Assembly Hall · Bloomington, IN |
| 22 | Sun Feb 1 | atMaryland | 1:00 PM | 6-3 | .667 | #1 | | XFINITY Center · College Park, MD |
| 23 | Sat Feb 7 | vsOregon | 1:00 PM | 4-4 | .500 | #1 | | Mackey Arena · West Lafayette, IN |
| 24 | Tue Feb 10 | atNebraska | 7:00 PM | 8-0 | 1.000 | #1 | FS1 | Pinnacle Bank Arena · Lincoln, NE |
| 25 | Sat Feb 14 | atIowa | TBD | 7-1 | .875 | #1 | | Carver-Hawkeye Arena · Iowa City, IA |
| 26 | Tue Feb 17 | vs#3Michigan | 6:30 PM | 7-0 | 1.000 | #1 | | Mackey Arena · West Lafayette, IN |
| 27 | Fri Feb 20 | vs#22Indiana | 8:00 PM | 7-1 | .875 | #1 | | Mackey Arena · West Lafayette, IN |
| 28 | Thu Feb 26 | vs#7Michigan St | 8:00 PM | 8-0 | 1.000 | #1 | | Mackey Arena · West Lafayette, IN |
| 29 | Sun Mar 1 | atOhio State | 1:30 PM | 6-1 | .857 | #1 | | Value City Arena · Columbus, OH |
| 30 | Wed Mar 4 | atNorthwestern | 8:30 PM | 5-3 | .625 | #1 | | Welsh-Ryan Arena · Evanston, IL |
| 31 | Sat Mar 7 | vsWisconsin | 4:00 PM | 6-2 | .750 | #1 | | Mackey Arena · West Lafayette, IN |
