| 1 | Mon Nov 6 | vs N Illinois | W92-70 | 1-0 | 1.000 | #5 | | Fiserv Forum · Milwaukee, WI |
| 2 | Fri Nov 10 | vs Rider | W95-65 | 2-0 | 1.000 | #5 | FS1 | Fiserv Forum · Milwaukee, WI |
| 3 | Tue Nov 14 | at #23Illinois | W71-64 | 3-0 | 1.000 | #4 | FS1 | State Farm Center · Champaign, IL |
| 4 | Mon Nov 20 | vs UCLA | W71-69 | 4-0 | 1.000 | #4 | ESPN2 | Fiserv Forum · Milwaukee, WI |
| 5 | Tue Nov 21 | vs #1Kansas | W73-59 | 5-0 | 1.000 | #4 | ESPN | Fiserv Forum · Milwaukee, WI |
| 6 | Wed Nov 22 | vs #2Purdue | L75-78 | 5-1 | .833 | #4 | ESPN | Fiserv Forum · Milwaukee, WI |
| 7 | Tue Nov 28 | vs Southern | W93-56 | 6-1 | .857 | #3 | FS1 | Fiserv Forum · Milwaukee, WI |
| 8 | Sat Dec 2 | at Wisconsin | L64-75 | 6-2 | .750 | #3 | FOX | Kohl Center · Madison, WI |
| 9 | Wed Dec 6 | vs #12Texas | W86-65 | 7-2 | .778 | #8 | FS1 | Fiserv Forum · Milwaukee, WI |
| 10 | Sat Dec 9 | vs Notre Dame | W78-59 | 8-2 | .800 | #8 | FOX | Fiserv Forum · Milwaukee, WI |
| 11 | Thu Dec 14 | vs St Thomas (MN) | W84-79 | 9-2 | .818 | #7 | FS1 | Fiserv Forum · Milwaukee, WI |
| 12 | Tue Dec 19 | at Providence | L57-72 | 9-3 | .750 | #6 | FS1 | Amica Mutual Pavilion · Providence, RI |
| 13 | Fri Dec 22 | vs Georgetown | W81-51 | 10-3 | .769 | #6 | FS1 | Fiserv Forum · Milwaukee, WI |
| 14 | Sat Dec 30 | vs #22Creighton | W72-67 | 11-3 | .786 | #10 | CBS | Fiserv Forum · Milwaukee, WI |
| 15 | Sat Jan 6 | at Seton Hall | L75-78 | 11-4 | .733 | #7 | CBS | Prudential Center · Newark, NJ |
| 16 | Wed Jan 10 | vs Butler | L62-69 | 11-5 | .688 | #11 | CBS | Fiserv Forum · Milwaukee, WI |
| 17 | Mon Jan 15 | vs Villanova | W87-74 | 12-5 | .706 | #17 | FOX | Fiserv Forum · Milwaukee, WI |
| 18 | Sat Jan 20 | at St John's | W73-72 | 13-5 | .722 | #17 | FOX | Carnesecca Arena · Queens, NY |
| 19 | Wed Jan 24 | at DePaul | W86-73 | 14-5 | .737 | #14 | CBS | Wintrust Arena · Chicago, IL |
| 20 | Sat Jan 27 | vsSeton Hall | W75-57 | 15-5 | .750 | #14 | FS1 | Fiserv Forum · Milwaukee, WI |
| 21 | Tue Jan 30 | atVillanova | W85-80 | 16-5 | .762 | #9 | FS1 | Finneran Pavilion · Villanova, PA |
| 22 | Sat Feb 3 | atGeorgetown | W91-57 | 17-5 | .773 | #9 | FS1 | Capital One Arena · Washington, D.C. |
| 23 | Sat Feb 10 | vsSt John's | W86-75 | 18-5 | .783 | #7 | FS1 | Fiserv Forum · Milwaukee, WI |
| 24 | Tue Feb 13 | atButler | W78-72 | 19-5 | .792 | #4 | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 25 | Sat Feb 17 | at #1UConn | L53-81 | 19-6 | .760 | #4 | FOX | Gampel Pavilion · Storrs, CT |
| 26 | Wed Feb 21 | vsDePaul | W105-71 | 20-6 | .769 | #7 | FS1 | Fiserv Forum · Milwaukee, WI |
| 27 | Sun Feb 25 | vs Xavier | W88-64 | 21-6 | .778 | #7 | FS1 | Fiserv Forum · Milwaukee, WI |
| 28 | Wed Feb 28 | vsProvidence | W91-69 | 22-6 | .786 | #5 | FS1 | Fiserv Forum · Milwaukee, WI |
| 29 | Sat Mar 2 | at#12Creighton | L75-89 | 22-7 | .759 | #5 | FOX | CHI Health Center Omaha · Omaha, NE |
| 30 | Wed Mar 6 | vs#2UConn | L67-74 | 22-8 | .733 | #8 | FS1 | Fiserv Forum · Milwaukee, WI |
| 31 | Sat Mar 9 | atXavier | W86-80 | 23-8 | .742 | #8 | FOX | Cintas Center · Cincinnati, OH |
| 32 | Thu Mar 14 | vsVillanova | W71-65 (OT) | 24-8 | .750 | #10 | FS1 | Fiserv Forum · Milwaukee, WI |
| 33 | Fri Mar 15 | vsProvidence | W79-68 | 25-8 | .758 | #10 | FS1 | Fiserv Forum · Milwaukee, WI |
| 34 | Sat Mar 16 | at#2UConn | L57-73 | 25-9 | .735 | #10 | FOX | Gampel Pavilion · Storrs, CT |
| 35 | Fri Mar 22 | vs #15Western KY | W87-69 | 26-9 | .743 | #2 | TBS | Fiserv Forum · Milwaukee, WI |
| 36 | Sun Mar 24 | vs #10Colorado | W81-77 | 27-9 | .750 | #2 | CBS | Fiserv Forum · Milwaukee, WI |
| 37 | Fri Mar 29 | vs #11NC State | L58-67 | 27-10 | .730 | #2 | CBS | Fiserv Forum · Milwaukee, WI |
