| 1 | Mon Nov 7 | vs Radford | W79-69 | 1-0 | 1.000 | - | | Fiserv Forum · Milwaukee, WI |
| 2 | Thu Nov 10 | vs C Michigan | W97-73 | 2-0 | 1.000 | - | FS2 | Fiserv Forum · Milwaukee, WI |
| 3 | Tue Nov 15 | at Purdue | L70-75 | 2-1 | .667 | - | FS1 | Mackey Arena · West Lafayette, IN |
| 4 | Thu Nov 17 | vs Long Island | W95-58 | 3-1 | .750 | - | FS2 | Fiserv Forum · Milwaukee, WI |
| 5 | Mon Nov 21 | at Mississippi St | L55-58 | 3-2 | .600 | - | FS1 | Humphrey Coliseum · Starkville, MS |
| 6 | Wed Nov 23 | at Georgia Tech | W84-60 | 4-2 | .667 | - | FS1 | McCamish Pavilion · Atlanta, GA |
| 7 | Sat Nov 26 | vs Chicago St | W82-68 | 5-2 | .714 | - | FS2 | Fiserv Forum · Milwaukee, WI |
| 8 | Tue Nov 29 | vs Baylor | W96-70 | 6-2 | .750 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 9 | Sat Dec 3 | vs Wisconsin | L77-80 (OT) | 6-3 | .667 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 10 | Tue Dec 6 | vs NC Central | W90-78 | 7-3 | .700 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 11 | Sun Dec 11 | at Notre Dame | W79-64 | 8-3 | .727 | - | ESPN2 | Purcell Pavilion · South Bend, IN |
| 12 | Fri Dec 16 | vs Creighton | W69-58 | 9-3 | .750 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 13 | Tue Dec 20 | at Providence | L98-103 (2OT) | 9-4 | .692 | #24 | CBS | Amica Mutual Pavilion · Providence, RI |
| 14 | Tue Dec 27 | vs Seton Hall | W83-69 | 10-4 | .714 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 15 | Sat Dec 31 | at Villanova | W68-66 | 11-4 | .733 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 16 | Tue Jan 3 | at St John's | W96-85 | 12-4 | .750 | - | FS1 | Carnesecca Arena · Queens, NY |
| 17 | Sat Jan 7 | vs Georgetown | W95-73 | 13-4 | .765 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 18 | Wed Jan 11 | vs #6UConn | W82-76 | 14-4 | .778 | #25 | CBS | Fiserv Forum · Milwaukee, WI |
| 19 | Sun Jan 15 | at #12Xavier | L76-80 | 14-5 | .737 | #25 | FOX | Cintas Center · Cincinnati, OH |
| 20 | Wed Jan 18 | vs#22Providence | W83-75 | 15-5 | .750 | #20 | CBS | Fiserv Forum · Milwaukee, WI |
| 21 | Sat Jan 21 | atSeton Hall | W74-53 | 16-5 | .762 | #20 | CBS | Prudential Center · Newark, NJ |
| 22 | Sat Jan 28 | at DePaul | W89-69 | 17-5 | .773 | #16 | FS1 | Wintrust Arena · Chicago, IL |
| 23 | Wed Feb 1 | vsVillanova | W73-64 | 18-5 | .783 | #14 | FS1 | Fiserv Forum · Milwaukee, WI |
| 24 | Sat Feb 4 | vs Butler | W60-52 | 19-5 | .792 | #14 | FS1 | Fiserv Forum · Milwaukee, WI |
| 25 | Tue Feb 7 | at#21UConn | L72-87 | 19-6 | .760 | #10 | FS1 | Gampel Pavilion · Storrs, CT |
| 26 | Sat Feb 11 | atGeorgetown | W89-75 | 20-6 | .769 | #10 | FS1 | Capital One Arena · Washington, D.C. |
| 27 | Wed Feb 15 | vs#16Xavier | W69-68 | 21-6 | .778 | #11 | CBS | Fiserv Forum · Milwaukee, WI |
| 28 | Tue Feb 21 | at#19Creighton | W73-71 | 22-6 | .786 | #10 | FS1 | CHI Health Center Omaha · Omaha, NE |
| 29 | Sat Feb 25 | vsDePaul | W90-84 | 23-6 | .793 | #10 | FS1 | Fiserv Forum · Milwaukee, WI |
| 30 | Tue Feb 28 | atButler | W72-56 | 24-6 | .800 | #6 | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 31 | Sat Mar 4 | vsSt John's | W96-94 | 25-6 | .806 | #6 | FOX | Fiserv Forum · Milwaukee, WI |
| 32 | Thu Mar 9 | vsSt John's | W72-70 (OT) | 26-6 | .813 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 33 | Fri Mar 10 | vsUConn | W70-68 | 27-6 | .818 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 34 | Sat Mar 11 | vsXavier | W65-51 | 28-6 | .824 | - | FOX | Fiserv Forum · Milwaukee, WI |
| 35 | Fri Mar 17 | vs #15Vermont | W78-61 | 29-6 | .829 | #2 | CBS | Fiserv Forum · Milwaukee, WI |
| 36 | Sun Mar 19 | vs #7Michigan St | L60-69 | 29-7 | .806 | #2 | CBS | Fiserv Forum · Milwaukee, WI |
