| 1 | Mon Nov 7 | vs Radford | W79-69 | -19½ | 1-0 | 1.000 | - | | Fiserv Forum · Milwaukee, WI |
| 2 | Thu Nov 10 | vs C Michigan | W97-73 | -17½ | 2-0 | 1.000 | - | FS2 | Fiserv Forum · Milwaukee, WI |
| 3 | Tue Nov 15 | at Purdue | L70-75 | +8 | 2-1 | .667 | - | FS1 | Mackey Arena · West Lafayette, IN |
| 4 | Thu Nov 17 | vs Long Island | W95-58 | -29½ | 3-1 | .750 | - | FS2 | Fiserv Forum · Milwaukee, WI |
| 5 | Mon Nov 21 | at Mississippi St | L55-58 | -3½ | 3-2 | .600 | - | FS1 | Humphrey Coliseum · Starkville, MS |
| 6 | Wed Nov 23 | at Georgia Tech | W84-60 | +7 | 4-2 | .667 | - | FS1 | McCamish Pavilion · Atlanta, GA |
| 7 | Sat Nov 26 | vs Chicago St | W82-68 | -27½ | 5-2 | .714 | - | FS2 | Fiserv Forum · Milwaukee, WI |
| 8 | Tue Nov 29 | vs Baylor | W96-70 | +5½ | 6-2 | .750 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 9 | Sat Dec 3 | vs Wisconsin | L77-80 (OT) | -5½ | 6-3 | .667 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 10 | Tue Dec 6 | vs NC Central | W90-78 | -19 | 7-3 | .700 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 11 | Sun Dec 11 | at Notre Dame | W79-64 | -1½ | 8-3 | .727 | - | ESPN2 | Purcell Pavilion · South Bend, IN |
| 12 | Fri Dec 16 | vs Creighton | W69-58 | -3½ | 9-3 | .750 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 13 | Tue Dec 20 | at Providence | L98-103 (2OT) | - | 9-4 | .692 | #24 | CBS Sports Network | Amica Mutual Pavilion · Providence, RI |
| 14 | Tue Dec 27 | vs Seton Hall | W83-69 | -7 | 10-4 | .714 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 15 | Sat Dec 31 | at Villanova | W68-66 | +2½ | 11-4 | .733 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 16 | Tue Jan 3 | at St John's | W96-85 | -3 | 12-4 | .750 | - | FS1 | Carnesecca Arena · Queens, NY |
| 17 | Sat Jan 7 | vs Georgetown | W95-73 | -18½ | 13-4 | .765 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 18 | Wed Jan 11 | vs 6UConn | W82-76 | +2½ | 14-4 | .778 | #25 | CBS Sports Network | Fiserv Forum · Milwaukee, WI |
| 19 | Sun Jan 15 | at 12Xavier | L76-80 | +3½ | 14-5 | .737 | #25 | FOX | Cintas Center · Cincinnati, OH |
| 20 | Wed Jan 18 | vs 22Providence | W83-75 | -7½ | 15-5 | .750 | #20 | CBS Sports Network | Fiserv Forum · Milwaukee, WI |
| 21 | Sat Jan 21 | at Seton Hall | W74-53 | -1½ | 16-5 | .762 | #20 | CBS Sports Network | Prudential Center · Newark, NJ |
| 22 | Sat Jan 28 | at DePaul | W89-69 | -9½ | 17-5 | .773 | #16 | FS1 | Wintrust Arena · Chicago, IL |
| 23 | Wed Feb 1 | vs Villanova | W73-64 | -6½ | 18-5 | .783 | #14 | FS1 | Fiserv Forum · Milwaukee, WI |
| 24 | Sat Feb 4 | vs Butler | W60-52 | -15 | 19-5 | .792 | #14 | FS1 | Fiserv Forum · Milwaukee, WI |
| 25 | Tue Feb 7 | at 21UConn | L72-87 | +5 | 19-6 | .760 | #10 | FS1 | Gampel Pavilion · Storrs, CT |
| 26 | Sat Feb 11 | at Georgetown | W89-75 | -11 | 20-6 | .769 | #10 | FS1 | Capital One Arena · Washington, D.C. |
| 27 | Wed Feb 15 | vs 16Xavier | W69-68 | -7 | 21-6 | .778 | #11 | CBS Sports Network | Fiserv Forum · Milwaukee, WI |
| 28 | Tue Feb 21 | at 19Creighton | W73-71 | +6½ | 22-6 | .786 | #10 | FS1 | CHI Health Center Omaha · Omaha, NE |
| 29 | Sat Feb 25 | vs DePaul | W90-84 | -14 | 23-6 | .793 | #10 | FS1 | Fiserv Forum · Milwaukee, WI |
| 30 | Tue Feb 28 | at Butler | W72-56 | -8 | 24-6 | .800 | #6 | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 31 | Sat Mar 4 | vs St John's | W96-94 | -11½ | 25-6 | .806 | #6 | FOX | Fiserv Forum · Milwaukee, WI |
| 32 | Thu Mar 9 | vs St John's | W72-70 (OT) | -8 | 26-6 | .813 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 33 | Fri Mar 10 | vs UConn | W70-68 | +4½ | 27-6 | .818 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 34 | Sat Mar 11 | vs Xavier | W65-51 | -2 | 28-6 | .824 | - | FOX | Fiserv Forum · Milwaukee, WI |
| 35 | Fri Mar 17 | vs 15Vermont | W78-61 | -10½ | 29-6 | .829 | #2 | CBS | Fiserv Forum · Milwaukee, WI |
| 36 | Sun Mar 19 | vs 7Michigan St | L60-69 | -3½ | 29-7 | .806 | #2 | CBS | Fiserv Forum · Milwaukee, WI |