| 1 | Wed Nov 25 | vs AR-Pine Bluff | W99-57 | 1-0 | 1.000 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 2 | Fri Nov 27 | vsE Illinois | W75-50 | 2-0 | 1.000 | - | | Fiserv Forum · Milwaukee, WI |
| 3 | Tue Dec 1 | vsOklahoma St | L62-70 | 2-1 | .667 | - | | Fiserv Forum · Milwaukee, WI |
| 4 | Fri Dec 4 | vs4Wisconsin | W67-65 | 3-1 | .750 | - | | Fiserv Forum · Milwaukee, WI |
| 5 | Tue Dec 8 | vsGreen Bay | W82-68 | 4-1 | .800 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 6 | Fri Dec 11 | atUCLA | L60-69 | 4-2 | .667 | - | PACN | Pauley Pavilion · Los Angeles, CA |
| 7 | Mon Dec 14 | at9Creighton | W89-84 | 5-2 | .714 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 8 | Thu Dec 17 | vsSeton Hall | L63-70 | 5-3 | .625 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 9 | Sun Dec 20 | atXavier | L88-91 | 5-4 | .556 | - | FS1 | Cintas Center · Cincinnati, OH |
| 10 | Wed Dec 23 | vs5Villanova | L68-85 | 5-5 | .500 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 11 | Sat Jan 2 | atGeorgetown | W64-60 | 6-5 | .545 | - | CBSSN | Capital One Arena · Washington, D.C. |
| 12 | Tue Jan 5 | vsUConn | L54-65 | 6-6 | .500 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 13 | Fri Jan 8 | at3Villanova | PPD | 13-14 | .481 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 14 | Tue Jan 12 | vsProvidence | W79-69 | 7-6 | .538 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 15 | Sat Jan 16 | atSt John's | W73-71 | 8-6 | .571 | - | FS1 | Carnesecca Arena · Queens, NY |
| 17 | Sat Jan 23 | vsDePaul | L61-68 | 8-7 | .533 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 18 | Wed Jan 27 | atProvidence | L63-72 (OT) | 8-8 | .500 | - | CBSSN | Amica Mutual Pavilion · Providence, RI |
| 19 | Sun Jan 31 | vsSt John's | L73-75 | 8-9 | .471 | - | FOX | Fiserv Forum · Milwaukee, WI |
| 20 | Tue Feb 2 | vsButler | W70-67 | 9-9 | .500 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 21 | Sat Feb 6 | vs15Creighton | L68-71 | 9-10 | .474 | - | | Fiserv Forum · Milwaukee, WI |
| 22 | Wed Feb 10 | at5Villanova | L64-96 | 9-11 | .450 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 23 | Sun Feb 14 | atSeton Hall | L51-57 | 9-12 | .429 | - | FS1 | Prudential Center · Newark, NJ |
| 24 | Wed Feb 17 | atButler | W73-57 | 10-12 | .455 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 25 | Wed Feb 24 | atUNC | W83-70 | 11-12 | .478 | - | ESPN2 | Dean E. Smith Center · Chapel Hill, NC |
| 26 | Sat Feb 27 | atUConn | L62-80 | 11-13 | .458 | - | FOX | Gampel Pavilion · Storrs, CT |
| 27 | Tue Mar 2 | atDePaul | W77-71 | 12-13 | .480 | - | FS1 | Wintrust Arena · Chicago, IL |
| 28 | Sat Mar 6 | vsXavier | W66-59 | 13-13 | .500 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 29 | Wed Mar 10 | atGeorgetown | L49-68 | 13-14 | .481 | - | FS1 | Capital One Arena · Washington, D.C. |
