| 1 | Mon Nov 3 | vs Albany | W80-53 | 1-0 | 1.000 | - | ESPN+ | Fiserv Forum · Milwaukee, WI |
| 2 | Wed Nov 5 | vsSouthern | W100-82 | 2-0 | 1.000 | - | ESPN+ | Fiserv Forum · Milwaukee, WI |
| 3 | Sun Nov 9 | vsIndiana | L77-100 | 2-1 | .667 | - | ESPN | Fiserv Forum · Milwaukee, WI |
| 4 | Wed Nov 12 | vsLittle Rock | W89-49 | 3-1 | .750 | - | ESPN+ | Fiserv Forum · Milwaukee, WI |
| 5 | Sat Nov 15 | vsMaryland | L82-89 | 3-2 | .600 | - | Peacock | Fiserv Forum · Milwaukee, WI |
| 6 | Wed Nov 19 | vsDayton | L71-77 (OT) | 3-3 | .500 | - | truTV | Fiserv Forum · Milwaukee, WI |
| 7 | Sat Nov 22 | vsC Michigan | W85-71 | 4-3 | .571 | - | truTV | Fiserv Forum · Milwaukee, WI |
| 8 | Fri Nov 28 | vsOklahoma | L74-75 | 4-4 | .500 | - | NBC | Credit Union 1 Arena · Chicago, IL |
| 9 | Tue Dec 2 | vsValparaiso | W75-72 (OT) | 5-4 | .556 | - | ESPN+ | Fiserv Forum · Milwaukee, WI |
| 10 | Sat Dec 6 | atWisconsin | L76-96 | 5-5 | .500 | - | FS1 | Kohl Center · Madison, WI |
| 11 | Sat Dec 13 | at6Purdue | L59-79 | 5-6 | .455 | - | Peacock | Mackey Arena · West Lafayette, IN |
| 12 | Wed Dec 17 | vsGeorgetown | L69-78 | 5-7 | .417 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 13 | Sat Dec 20 | atCreighton | L63-84 | 5-8 | .385 | - | Peacock | CHI Health Center Omaha · Omaha, NE |
| 14 | Tue Dec 30 | vsSeton Hall | L73-79 | 5-9 | .357 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 15 | Sun Jan 4 | at4UConn | L57-73 | 5-10 | .333 | - | NBC | Gampel Pavilion · Storrs, CT |
| 16 | Wed Jan 7 | vsXavier | W66-65 | 6-10 | .375 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 17 | Sat Jan 10 | vsVillanova | L73-76 | 6-11 | .353 | - | TNT | Fiserv Forum · Milwaukee, WI |
| 18 | Tue Jan 13 | atSt John's | L68-92 | 6-12 | .333 | - | Peacock | Carnesecca Arena · Queens, NY |
| 19 | Fri Jan 16 | atDePaul | L75-80 | 6-13 | .316 | - | FS1 | Wintrust Arena · Chicago, IL |
| 20 | Mon Jan 19 | vsProvidence | W105-104 (OT) | 7-13 | .350 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 21 | Fri Jan 23 | atButler | L76-87 | 7-14 | .333 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 22 | Tue Jan 27 | vsCreighton | W86-62 | 8-14 | .364 | - | TNT | Fiserv Forum · Milwaukee, WI |
| 23 | Sat Jan 31 | atSeton Hall | L64-69 | 8-15 | .348 | - | Peacock | Prudential Center · Newark, NJ |
| 24 | Sat Feb 7 | vsButler | W70-55 | 9-15 | .375 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 25 | Tue Feb 10 | atVillanova | L74-77 | 9-16 | .360 | - | TNT | Finneran Pavilion · Villanova, PA |
| 26 | Sat Feb 14 | atXavier | L88-96 | 9-17 | .346 | - | TNT | Cintas Center · Cincinnati, OH |
| 27 | Wed Feb 18 | vs17St John's | L70-76 | 9-18 | .333 | - | TNT | Fiserv Forum · Milwaukee, WI |
| 28 | Tue Feb 24 | atGeorgetown | W76-60 | 10-18 | .357 | - | Peacock | Capital One Arena · Washington, D.C. |
| 29 | Sun Mar 1 | vsDePaul | L51-62 | 10-19 | .345 | - | FS1 | Fiserv Forum · Milwaukee, WI |
