| 1 | Mon Nov 3 | vs Chicago St | 8:00 PM | 4-28 | .125 | - | | Wintrust Arena · Chicago, IL |
| 2 | Fri Nov 7 | vsStonehill | TBD | 15-17 | .469 | - | | Wintrust Arena · Chicago, IL |
| 3 | Tue Nov 11 | vsBuffalo | 8:00 PM | 9-22 | .290 | - | | Wintrust Arena · Chicago, IL |
| 4 | Fri Nov 14 | vsNorthwestern | TBD | 17-16 | .515 | - | | Wintrust Arena · Chicago, IL |
| 5 | Tue Nov 18 | vsGardner-Webb | TBD | 11-20 | .355 | - | | Wintrust Arena · Chicago, IL |
| 6 | Sun Nov 23 | vsDetroit Mercy | TBD | 8-24 | .250 | - | | Wintrust Arena · Chicago, IL |
| 7 | Fri Nov 28 | vsGeorgia Tech | 7:00 PM | 17-17 | .500 | - | | Wintrust Arena · Chicago, IL |
| 8 | Sat Dec 6 | vsAR-Pine Bluff | TBD | 6-25 | .194 | - | | Wintrust Arena · Chicago, IL |
| 9 | Tue Dec 9 | vsMorgan St | TBD | 14-18 | .438 | - | | Wintrust Arena · Chicago, IL |
| 10 | Sat Dec 13 | atWichita St | TBD | 19-15 | .559 | - | | Charles Koch Arena · Wichita, KS |
| 11 | Tue Dec 16 | at#5St John's | TBD | 31-5 | .861 | - | | Carnesecca Arena · Queens, NY |
| 12 | Sun Dec 21 | vs#4UConn | 4:30 PM | 24-11 | .686 | - | | Wintrust Arena · Chicago, IL |
| 13 | Wed Dec 31 | atVillanova | TBD | 21-15 | .583 | - | | Finneran Pavilion · Villanova, PA |
| 14 | Sat Jan 3 | vsXavier | TBD | 22-12 | .647 | - | | Wintrust Arena · Chicago, IL |
| 15 | Tue Jan 6 | vsGeorgetown | TBD | 18-16 | .529 | - | | Wintrust Arena · Chicago, IL |
| 16 | Sat Jan 10 | at#4UConn | 12:30 PM | 24-11 | .686 | - | | Gampel Pavilion · Storrs, CT |
| 17 | Fri Jan 16 | vsMarquette | TBD | 23-11 | .676 | - | | Wintrust Arena · Chicago, IL |
| 18 | Tue Jan 20 | atButler | TBD | 15-20 | .429 | - | | Hinkle Fieldhouse · Indianapolis, IN |
| 19 | Sat Jan 24 | vsSeton Hall | TBD | 7-25 | .219 | - | | Wintrust Arena · Chicago, IL |
| 20 | Wed Jan 28 | atGeorgetown | TBD | 18-16 | .529 | - | | Capital One Arena · Washington, D.C. |
| 21 | Sat Jan 31 | atXavier | TBD | 22-12 | .647 | - | | Cintas Center · Cincinnati, OH |
| 22 | Tue Feb 3 | vs#5St John's | TBD | 31-5 | .861 | - | | Wintrust Arena · Chicago, IL |
| 23 | Sat Feb 7 | atProvidence | TBD | 12-20 | .375 | - | | Amica Mutual Pavilion · Providence, RI |
| 24 | Wed Feb 11 | vs#23Creighton | TBD | 25-11 | .694 | - | | Wintrust Arena · Chicago, IL |
| 25 | Wed Feb 18 | atSeton Hall | TBD | 7-25 | .219 | - | | Prudential Center · Newark, NJ |
| 26 | Sat Feb 21 | vsProvidence | TBD | 12-20 | .375 | - | | Wintrust Arena · Chicago, IL |
| 27 | Wed Feb 25 | at#23Creighton | TBD | 25-11 | .694 | - | | CHI Health Center Omaha · Omaha, NE |
| 28 | Sun Mar 1 | atMarquette | TBD | 23-11 | .676 | - | | Fiserv Forum · Milwaukee, WI |
| 29 | Wed Mar 4 | vsVillanova | TBD | 21-15 | .583 | - | | Wintrust Arena · Chicago, IL |
| 30 | Sat Mar 7 | vsButler | TBD | 15-20 | .429 | - | | Wintrust Arena · Chicago, IL |
