| 3 | Tue Nov 11 | vs Buffalo | 8:00 PM | 2-0 | 1.000 | - | ESPN+ | Wintrust Arena · Chicago, IL |
| 4 | Fri Nov 14 | vsNorthwestern | 8:30 PM | 2-0 | 1.000 | - | truTV | Wintrust Arena · Chicago, IL |
| 5 | Tue Nov 18 | vsGardner-Webb | 8:00 PM | 0-2 | .000 | - | ESPN+ | Wintrust Arena · Chicago, IL |
| 6 | Sun Nov 23 | vsDetroit Mercy | 6:00 PM | 0-2 | .000 | - | ESPN+ | Wintrust Arena · Chicago, IL |
| 7 | Fri Nov 28 | vsGeorgia Tech | 7:00 PM | 2-0 | 1.000 | - | | Wintrust Arena · Chicago, IL |
| 8 | Sat Dec 6 | vsAR-Pine Bluff | 9:00 PM | 0-2 | .000 | - | | Wintrust Arena · Chicago, IL |
| 9 | Tue Dec 9 | vsMorgan St | 8:00 PM | 1-1 | .500 | - | ESPN+ | Wintrust Arena · Chicago, IL |
| 10 | Sat Dec 13 | atWichita St | 12:00 PM | 1-0 | 1.000 | - | ESPNU | Charles Koch Arena · Wichita, KS |
| 11 | Tue Dec 16 | at#5St John's | 7:00 PM | 1-1 | .500 | - | | Carnesecca Arena · Queens, NY |
| 12 | Sun Dec 21 | vs#4UConn | 4:30 PM | 2-0 | 1.000 | - | | Wintrust Arena · Chicago, IL |
| 13 | Wed Dec 31 | atVillanova | 6:00 PM | 0-1 | .000 | - | | Finneran Pavilion · Villanova, PA |
| 14 | Sat Jan 3 | vsXavier | 2:00 PM | 2-0 | 1.000 | - | | Wintrust Arena · Chicago, IL |
| 15 | Tue Jan 6 | vsGeorgetown | 8:00 PM | 2-0 | 1.000 | - | | Wintrust Arena · Chicago, IL |
| 16 | Sat Jan 10 | at#4UConn | 12:30 PM | 2-0 | 1.000 | - | | Gampel Pavilion · Storrs, CT |
| 17 | Fri Jan 16 | vsMarquette | 8:30 PM | 2-0 | 1.000 | - | | Wintrust Arena · Chicago, IL |
| 18 | Tue Jan 20 | atButler | 7:30 PM | 2-0 | 1.000 | - | | Hinkle Fieldhouse · Indianapolis, IN |
| 19 | Sat Jan 24 | vsSeton Hall | 5:00 PM | 2-0 | 1.000 | - | | Wintrust Arena · Chicago, IL |
| 20 | Wed Jan 28 | atGeorgetown | 8:30 PM | 2-0 | 1.000 | - | | Capital One Arena · Washington, D.C. |
| 21 | Sat Jan 31 | atXavier | 1:00 PM | 2-0 | 1.000 | - | | Cintas Center · Cincinnati, OH |
| 22 | Tue Feb 3 | vs#5St John's | 8:00 PM | 1-1 | .500 | - | | Wintrust Arena · Chicago, IL |
| 23 | Sat Feb 7 | atProvidence | 4:00 PM | 1-1 | .500 | - | | Amica Mutual Pavilion · Providence, RI |
| 24 | Wed Feb 11 | vs#23Creighton | 9:00 PM | 1-0 | 1.000 | - | | Wintrust Arena · Chicago, IL |
| 25 | Wed Feb 18 | atSeton Hall | 8:00 PM | 2-0 | 1.000 | - | | Prudential Center · Newark, NJ |
| 26 | Sat Feb 21 | vsProvidence | 8:00 PM | 1-1 | .500 | - | | Wintrust Arena · Chicago, IL |
| 27 | Wed Feb 25 | at#23Creighton | 9:00 PM | 1-0 | 1.000 | - | | CHI Health Center Omaha · Omaha, NE |
| 28 | Sun Mar 1 | atMarquette | 4:00 PM | 2-0 | 1.000 | - | | Fiserv Forum · Milwaukee, WI |
| 29 | Wed Mar 4 | vsVillanova | 8:00 PM | 0-1 | .000 | - | | Wintrust Arena · Chicago, IL |
| 30 | Sat Mar 7 | vsButler | 12:00 PM | 2-0 | 1.000 | - | | Wintrust Arena · Chicago, IL |
