| 1 | Mon Nov 3 | vs Chicago St | W92-62 | 1-0 | 1.000 | - | ESPN+ | Wintrust Arena · Chicago, IL |
| 2 | Fri Nov 7 | vsStonehill | W72-64 | 2-0 | 1.000 | - | ESPN+ | Wintrust Arena · Chicago, IL |
| 3 | Tue Nov 11 | vsBuffalo | L53-66 | 2-1 | .667 | - | ESPN+ | Wintrust Arena · Chicago, IL |
| 4 | Fri Nov 14 | vsNorthwestern | L79-81 | 2-2 | .500 | - | truTV | Wintrust Arena · Chicago, IL |
| 5 | Tue Nov 18 | vsGardner-Webb | W93-62 | 3-2 | .600 | - | ESPN+ | Wintrust Arena · Chicago, IL |
| 6 | Sun Nov 23 | vsDetroit Mercy | W95-75 | 4-2 | .667 | - | ESPN+ | Wintrust Arena · Chicago, IL |
| 7 | Fri Nov 28 | vsGeorgia Tech | W75-61 | 5-2 | .714 | - | CBSSN | Wintrust Arena · Chicago, IL |
| 8 | Sat Nov 29 | atLSU | L63-96 | 5-3 | .625 | - | | Pete Maravich Assembly Center · Baton Rouge, LA |
| 9 | Sat Dec 6 | vsAR-Pine Bluff | W76-72 | 6-3 | .667 | - | truTV | Wintrust Arena · Chicago, IL |
| 10 | Tue Dec 9 | vsMorgan St | W92-49 | 7-3 | .700 | - | ESPN+ | Wintrust Arena · Chicago, IL |
| 11 | Sat Dec 13 | atWichita St | W61-58 | 8-3 | .727 | - | ESPNU | Charles Koch Arena · Wichita, KS |
| 12 | Tue Dec 16 | at22St John's | L66-79 | 8-4 | .667 | - | Peacock | Carnesecca Arena · Queens, NY |
| 13 | Sun Dec 21 | vs5UConn | L54-72 | 8-5 | .615 | - | FS1 | Wintrust Arena · Chicago, IL |
| 14 | Wed Dec 31 | atVillanova | L66-71 | 8-6 | .571 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 15 | Sat Jan 3 | vsXavier | W86-77 | 9-6 | .600 | - | FS1 | Wintrust Arena · Chicago, IL |
| 16 | Tue Jan 6 | vsGeorgetown | W56-50 | 10-6 | .625 | - | truTV | Wintrust Arena · Chicago, IL |
| 17 | Sat Jan 10 | at4UConn | L60-72 | 10-7 | .588 | - | TNT | Gampel Pavilion · Storrs, CT |
| 18 | Fri Jan 16 | vsMarquette | W80-75 | 11-7 | .611 | - | FS1 | Wintrust Arena · Chicago, IL |
| 19 | Tue Jan 20 | atButler | L80-87 | 11-8 | .579 | - | truTV | Hinkle Fieldhouse · Indianapolis, IN |
| 20 | Sat Jan 24 | vsSeton Hall | W67-60 | 12-8 | .600 | - | truTV | Wintrust Arena · Chicago, IL |
| 21 | Wed Jan 28 | atGeorgetown | L61-70 | 12-9 | .571 | - | FS1 | Capital One Arena · Washington, D.C. |
| 22 | Sat Jan 31 | atXavier | L66-68 | 12-10 | .545 | - | FS1 | Cintas Center · Cincinnati, OH |
| 23 | Tue Feb 3 | vs22St John's | L56-68 | 12-11 | .522 | - | Peacock | Wintrust Arena · Chicago, IL |
| 24 | Sat Feb 7 | atProvidence | L72-90 | 12-12 | .500 | - | FS1 | Amica Mutual Pavilion · Providence, RI |
| 25 | Wed Feb 11 | vsCreighton | W72-71 | 13-12 | .520 | - | Peacock | Wintrust Arena · Chicago, IL |
| 26 | Wed Feb 18 | atSeton Hall | W69-57 | 14-12 | .538 | - | truTV | Prudential Center · Newark, NJ |
| 27 | Sat Feb 21 | vsProvidence | L68-71 | 14-13 | .519 | - | FS1 | Wintrust Arena · Chicago, IL |
| 28 | Wed Feb 25 | atCreighton | W72-71 | 15-13 | .536 | - | Peacock | CHI Health Center Omaha · Omaha, NE |
| 29 | Sun Mar 1 | atMarquette | W62-51 | 16-13 | .552 | - | FS1 | Fiserv Forum · Milwaukee, WI |
