| 1 | Wed Nov 10 | vs Coppin St | W97-72 | 1-0 | 1.000 | - | FS1 | Wintrust Arena · Chicago, IL |
| 2 | Sat Nov 13 | vs C Michigan | W99-66 | 2-0 | 1.000 | - | FS2 | Wintrust Arena · Chicago, IL |
| 3 | Thu Nov 18 | vs Rutgers | W73-70 | 3-0 | 1.000 | - | FS1 | Wintrust Arena · Chicago, IL |
| 4 | Sat Nov 20 | vs W Illinois | W84-80 | 4-0 | 1.000 | - | FS2 | Wintrust Arena · Chicago, IL |
| 5 | Fri Nov 26 | vs N Kentucky | W77-68 | 5-0 | 1.000 | - | FS2 | Wintrust Arena · Chicago, IL |
| 6 | Sun Nov 28 | vs E Michigan | W101-63 | 6-0 | 1.000 | - | FS1 | Wintrust Arena · Chicago, IL |
| 7 | Sat Dec 4 | vs Loyola Chicago | L64-68 | 6-1 | .857 | - | FS1 | Wintrust Arena · Chicago, IL |
| 8 | Tue Dec 7 | vs Duquesne | W87-67 | 7-1 | .875 | - | FS1 | Wintrust Arena · Chicago, IL |
| 9 | Fri Dec 10 | at Louisville | W62-55 | 8-1 | .889 | - | ACC Network | KFC Yum! Center · Louisville, KY |
| 10 | Tue Dec 14 | at UIC | W72-66 | 9-1 | .900 | - | | Credit Union 1 Arena · Chicago, IL |
| 12 | Thu Dec 23 | vs #15Seton Hall | PPD | 9-1 | .900 | - | | Wintrust Arena · Chicago, IL |
| 13 | Wed Dec 29 | at Butler | L59-63 | 9-2 | .818 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 14 | Sat Jan 1 | vs #21Providence | L53-70 | 9-3 | .750 | - | FOX | Wintrust Arena · Chicago, IL |
| 15 | Wed Jan 5 | at St John's | L84-89 | 9-4 | .692 | - | FS1 | Carnesecca Arena · Queens, NY |
| 16 | Sat Jan 8 | vs #19Villanova | L64-79 | 9-5 | .643 | - | FOX | Wintrust Arena · Chicago, IL |
| 17 | Tue Jan 11 | at Marquette | L76-87 | 9-6 | .600 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 18 | Thu Jan 13 | vs#20Seton Hall | W96-92 | 10-6 | .625 | - | FS1 | Wintrust Arena · Chicago, IL |
| 19 | Wed Jan 19 | vs #20Xavier | L67-68 | 10-7 | .588 | - | FS1 | Wintrust Arena · Chicago, IL |
| 20 | Sat Jan 22 | at Creighton | L47-60 | 10-8 | .556 | - | CBS | CHI Health Center Omaha · Omaha, NE |
| 21 | Tue Jan 25 | at#14Villanova | L43-67 | 10-9 | .526 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 22 | Sat Jan 29 | vs #20UConn | L50-57 | 10-10 | .500 | - | FS1 | Wintrust Arena · Chicago, IL |
| 23 | Sat Feb 5 | at#21Xavier | W69-65 | 11-10 | .524 | - | FS1 | Cintas Center · Cincinnati, OH |
| 24 | Wed Feb 9 | vs Georgetown | W82-74 | 12-10 | .545 | - | FS1 | Wintrust Arena · Chicago, IL |
| 25 | Sat Feb 12 | at#11Providence | L73-76 (OT) | 12-11 | .522 | - | FS1 | Amica Mutual Pavilion · Providence, RI |
| 26 | Tue Feb 15 | vsButler | L71-73 | 12-12 | .500 | - | FS1 | Wintrust Arena · Chicago, IL |
| 27 | Thu Feb 17 | vsCreighton | L59-71 | 12-13 | .480 | - | CBS | Wintrust Arena · Chicago, IL |
| 28 | Sat Feb 19 | atSeton Hall | L64-66 | 12-14 | .462 | - | | Prudential Center · Newark, NJ |
| 29 | Thu Feb 24 | atGeorgetown | W68-65 | 13-14 | .481 | - | CBS | Capital One Arena · Washington, D.C. |
| 30 | Sun Feb 27 | vsSt John's | W99-94 | 14-14 | .500 | - | FS1 | Wintrust Arena · Chicago, IL |
| 31 | Wed Mar 2 | vsMarquette | W91-80 | 15-14 | .517 | - | CBS | Wintrust Arena · Chicago, IL |
| 32 | Sat Mar 5 | at#18UConn | L68-75 | 15-15 | .500 | - | FOX | Gampel Pavilion · Storrs, CT |
| 33 | Wed Mar 9 | atSt John's | L73-92 | 15-16 | .484 | - | FS1 | Carnesecca Arena · Queens, NY |
Northwestern