| 1 | Tue Nov 7 | vs Purdue FW | L74-82 | 0-1 | .000 | - | FS2 | Wintrust Arena · Chicago, IL |
| 2 | Sat Nov 11 | vsLong Beach St | L73-77 | 0-2 | .000 | - | FS2 | Wintrust Arena · Chicago, IL |
| 3 | Tue Nov 14 | vsSouth Dakota | W72-60 | 1-2 | .333 | - | FS2 | Wintrust Arena · Chicago, IL |
| 4 | Fri Nov 17 | vsSouth Carolina | L68-73 | 1-3 | .250 | - | CBS | Wintrust Arena · Chicago, IL |
| 5 | Sun Nov 19 | atSan Francisco | L54-70 | 1-4 | .200 | - | CBS | War Memorial at the Sobrato Center · San Francisco, CA |
| 6 | Sat Nov 25 | vsN Illinois | L79-89 | 1-5 | .167 | - | FS2 | Wintrust Arena · Chicago, IL |
| 7 | Fri Dec 1 | vsIowa State | L80-99 | 1-6 | .143 | - | FS1 | Wintrust Arena · Chicago, IL |
| 8 | Wed Dec 6 | at#21Texas A&M | L64-89 | 1-7 | .125 | - | SEC Network | Reed Arena · College Station, TX |
| 9 | Sat Dec 9 | vsLouisville | W75-68 | 2-7 | .222 | - | FS1 | Wintrust Arena · Chicago, IL |
| 10 | Sat Dec 16 | vs#25Northwestern | L46-56 | 2-8 | .200 | - | FS1 | Wintrust Arena · Chicago, IL |
| 11 | Sat Dec 23 | vsVillanova | L48-84 | 2-9 | .182 | - | FS1 | Wintrust Arena · Chicago, IL |
| 12 | Sat Dec 30 | vsChicago St | W70-58 | 3-9 | .250 | - | FS1 | Wintrust Arena · Chicago, IL |
| 13 | Tue Jan 2 | at#4UConn | L56-85 | 3-10 | .231 | - | FS1 | Gampel Pavilion · Storrs, CT |
| 14 | Sat Jan 6 | atGeorgetown | L65-68 | 3-11 | .214 | - | FS1 | Capital One Arena · Washington, D.C. |
| 15 | Tue Jan 9 | vs#22Creighton | L58-84 | 3-12 | .200 | - | CBS | Wintrust Arena · Chicago, IL |
| 16 | Fri Jan 12 | atVillanova | L69-94 | 3-13 | .188 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 17 | Wed Jan 17 | vsProvidence | L62-100 | 3-14 | .176 | - | FS1 | Wintrust Arena · Chicago, IL |
| 18 | Sat Jan 20 | atButler | L60-74 | 3-15 | .167 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 19 | Wed Jan 24 | vs#14Marquette | L73-86 | 3-16 | .158 | - | CBS | Wintrust Arena · Chicago, IL |
| 20 | Sat Jan 27 | at#17Creighton | L62-85 | 3-17 | .150 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 21 | Tue Jan 30 | vsSeton Hall | L39-72 | 3-18 | .143 | - | FS1 | Wintrust Arena · Chicago, IL |
| 22 | Sat Feb 3 | vsXavier | L68-93 | 3-19 | .136 | - | FS1 | Wintrust Arena · Chicago, IL |
| 23 | Tue Feb 6 | atSt John's | L57-85 | 3-20 | .130 | - | FS1 | Carnesecca Arena · Queens, NY |
| 24 | Wed Feb 14 | vs#1UConn | L65-101 | 3-21 | .125 | - | CBS | Wintrust Arena · Chicago, IL |
| 25 | Sat Feb 17 | atProvidence | L70-81 | 3-22 | .120 | - | FS1 | Amica Mutual Pavilion · Providence, RI |
| 26 | Wed Feb 21 | at#7Marquette | L71-105 | 3-23 | .115 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 27 | Sat Feb 24 | vsGeorgetown | L76-77 | 3-24 | .111 | - | CBS | Wintrust Arena · Chicago, IL |
| 28 | Wed Feb 28 | atXavier | L58-91 | 3-25 | .107 | - | FS2 | Cintas Center · Cincinnati, OH |
| 29 | Sat Mar 2 | vsButler | L63-82 | 3-26 | .103 | - | FS1 | Wintrust Arena · Chicago, IL |
| 30 | Tue Mar 5 | vsSt John's | L77-104 | 3-27 | .100 | - | FS1 | Wintrust Arena · Chicago, IL |
| 31 | Sat Mar 9 | atSeton Hall | L62-86 | 3-28 | .097 | - | FS1 | Prudential Center · Newark, NJ |
| 32 | Wed Mar 13 | atVillanova | L57-58 | 3-29 | .094 | - | FS1 | Finneran Pavilion · Villanova, PA |
