| 1 | Mon Nov 7 | vs Loyola MD | W72-66 | 1-0 | 1.000 | - | | Wintrust Arena · Chicago, IL |
| 2 | Fri Nov 11 | vsW Illinois | W86-74 | 2-0 | 1.000 | - | FS2 | Wintrust Arena · Chicago, IL |
| 3 | Mon Nov 14 | atMinnesota | W69-53 | 3-0 | 1.000 | - | BTN | Williams Arena · Minneapolis, MN |
| 4 | Fri Nov 18 | vsSanta Clara | L61-69 | 3-1 | .750 | - | CBSSN | Wintrust Arena · Chicago, IL |
| 5 | Sun Nov 20 | atOklahoma St | L78-82 | 3-2 | .600 | - | CBSSN | Gallagher-Iba Arena · Stillwater, OK |
| 6 | Fri Nov 25 | vsTexas A&M | L66-82 | 3-3 | .500 | - | FS1 | Wintrust Arena · Chicago, IL |
| 7 | Wed Nov 30 | vsSamford | W103-98 (OT) | 4-3 | .571 | - | FS2 | Wintrust Arena · Chicago, IL |
| 8 | Sat Dec 3 | atLoyola Chicago | W78-72 (OT) | 5-3 | .625 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 9 | Wed Dec 7 | atSt John's | L67-86 | 5-4 | .556 | - | FS1 | Carnesecca Arena · Queens, NY |
| 10 | Sat Dec 10 | vsUTEP | W91-70 | 6-4 | .600 | - | FS1 | Wintrust Arena · Chicago, IL |
| 11 | Wed Dec 14 | atDuquesne | L55-66 | 6-5 | .545 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 12 | Sat Dec 17 | atNorthwestern | L45-83 | 6-6 | .500 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 13 | Sun Dec 25 | atCreighton | L65-80 | 6-7 | .462 | - | FOX | CHI Health Center Omaha · Omaha, NE |
| 14 | Thu Dec 29 | vsGeorgetown | W83-76 | 7-7 | .500 | - | FS2 | Wintrust Arena · Chicago, IL |
| 15 | Sun Jan 1 | vsProvidence | L59-74 | 7-8 | .467 | - | FS1 | Wintrust Arena · Chicago, IL |
| 16 | Wed Jan 4 | atButler | L70-78 | 7-9 | .438 | - | CBSSN | Hinkle Fieldhouse · Indianapolis, IN |
| 17 | Tue Jan 10 | vsVillanova | W75-65 | 8-9 | .471 | - | CBSSN | Wintrust Arena · Chicago, IL |
| 18 | Sat Jan 14 | vsSeton Hall | L67-71 | 8-10 | .444 | - | FS1 | Wintrust Arena · Chicago, IL |
| 19 | Wed Jan 18 | vs8Xavier | W73-72 | 9-10 | .474 | - | FS1 | Wintrust Arena · Chicago, IL |
| 20 | Sat Jan 21 | at22Providence | L64-75 | 9-11 | .450 | - | FS1 | Amica Mutual Pavilion · Providence, RI |
| 21 | Tue Jan 24 | atGeorgetown | L76-81 | 9-12 | .429 | - | FS1 | Capital One Arena · Washington, D.C. |
| 22 | Sat Jan 28 | vs16Marquette | L69-89 | 9-13 | .409 | - | FS1 | Wintrust Arena · Chicago, IL |
| 23 | Tue Jan 31 | vs24UConn | L76-90 | 9-14 | .391 | - | FS1 | Wintrust Arena · Chicago, IL |
| 24 | Sun Feb 5 | atSeton Hall | L64-69 | 9-15 | .375 | - | FS1 | Prudential Center · Newark, NJ |
| 25 | Wed Feb 8 | atVillanova | L65-81 | 9-16 | .360 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 26 | Tue Feb 14 | vsSt John's | L83-92 (2OT) | 9-17 | .346 | - | FS1 | Wintrust Arena · Chicago, IL |
| 27 | Sat Feb 18 | at16Xavier | L68-82 | 9-18 | .333 | - | CBSSN | Cintas Center · Cincinnati, OH |
| 28 | Wed Feb 22 | vsButler | L58-59 | 9-19 | .321 | - | FS1 | Wintrust Arena · Chicago, IL |
| 29 | Sat Feb 25 | at10Marquette | L84-90 | 9-20 | .310 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 30 | Wed Mar 1 | at14UConn | L59-88 | 9-21 | .300 | - | CBSSN | Gampel Pavilion · Storrs, CT |
| 31 | Sat Mar 4 | vsCreighton | L70-84 | 9-22 | .290 | - | FS1 | Wintrust Arena · Chicago, IL |
| 32 | Wed Mar 8 | atSeton Hall | W66-65 | 10-22 | .313 | - | FS1 | Prudential Center · Newark, NJ |
| 33 | Thu Mar 9 | atXavier | L84-89 | 10-23 | .303 | - | FS1 | Cintas Center · Cincinnati, OH |
