| 1 | Tue Nov 5 | vs Alcorn St | W72-54 | 1-0 | 1.000 | - | FS2 | Wintrust Arena · Chicago, IL |
| 2 | Wed Nov 6 | vs TBD | W84-55 | 2-0 | 1.000 | - | FS2 | Wintrust Arena · Chicago, IL |
| 3 | Fri Nov 8 | vs Fairleigh | W70-59 | 3-0 | 1.000 | - | FS2 | Wintrust Arena · Chicago, IL |
| 4 | Mon Nov 11 | at Iowa | W93-78 | 4-0 | 1.000 | - | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 5 | Sat Nov 16 | vs Cornell | W75-54 | 5-0 | 1.000 | - | | Wintrust Arena · Chicago, IL |
| 6 | Sat Nov 23 | at Boston College | W72-67 | 6-0 | 1.000 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 7 | Tue Nov 26 | vs C Michigan | W88-75 | 7-0 | 1.000 | - | FS1 | Wintrust Arena · Chicago, IL |
| 8 | Fri Nov 29 | at Minnesota | W73-68 | 8-0 | 1.000 | - | | Williams Arena · Minneapolis, MN |
| 9 | Wed Dec 4 | vs Texas Tech | W65-60 (OT) | 9-0 | 1.000 | - | FS1 | Wintrust Arena · Chicago, IL |
| 10 | Sun Dec 8 | vs Buffalo | L69-74 | 9-1 | .900 | - | FS1 | Wintrust Arena · Chicago, IL |
| 11 | Sat Dec 14 | vs UIC | W86-65 | 10-1 | .909 | - | FS1 | Wintrust Arena · Chicago, IL |
| 12 | Wed Dec 18 | at Cleveland St | W73-65 | 11-1 | .917 | - | | Wolstein Center · Cleveland, OH |
| 13 | Sat Dec 21 | vs Northwestern | W83-78 | 12-1 | .923 | - | CBS | Wintrust Arena · Chicago, IL |
| 14 | Mon Dec 30 | vs Seton Hall | L66-74 | 12-2 | .857 | - | FS1 | Wintrust Arena · Chicago, IL |
| 15 | Sat Jan 4 | vs Providence | L65-66 | 12-3 | .800 | - | FS1 | Wintrust Arena · Chicago, IL |
| 16 | Sat Jan 11 | at St John's | L67-74 | 12-4 | .750 | - | | Carnesecca Arena · Queens, NY |
| 17 | Tue Jan 14 | at #14Villanova | L75-79 (OT) | 12-5 | .706 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 18 | Sat Jan 18 | vs #5Butler | W79-66 | 13-5 | .722 | - | | Wintrust Arena · Chicago, IL |
| 19 | Wed Jan 22 | vs Creighton | L68-83 | 13-6 | .684 | - | CBS | Wintrust Arena · Chicago, IL |
| 20 | Sat Jan 25 | vsSt John's | L66-79 | 13-7 | .650 | - | FS1 | Wintrust Arena · Chicago, IL |
| 21 | Wed Jan 29 | at#10Seton Hall | L57-64 | 13-8 | .619 | - | FS1 | Prudential Center · Newark, NJ |
| 22 | Sat Feb 1 | at Marquette | L72-76 | 13-9 | .591 | - | | Fiserv Forum · Milwaukee, WI |
| 23 | Tue Feb 4 | vs Xavier | L59-67 | 13-10 | .565 | - | FS1 | Wintrust Arena · Chicago, IL |
| 24 | Sat Feb 8 | at Georgetown | L72-76 | 13-11 | .542 | - | | Capital One Arena · Washington, D.C. |
| 25 | Sat Feb 15 | at#23Creighton | L64-93 | 13-12 | .520 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 26 | Wed Feb 19 | vs#12Villanova | L71-91 | 13-13 | .500 | - | CBS | Wintrust Arena · Chicago, IL |
| 27 | Sat Feb 22 | vsGeorgetown | W74-68 | 14-13 | .519 | - | FS1 | Wintrust Arena · Chicago, IL |
| 28 | Tue Feb 25 | atXavier | L67-78 | 14-14 | .500 | - | CBS | Cintas Center · Cincinnati, OH |
| 29 | Sat Feb 29 | atButler | L42-60 | 14-15 | .483 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 30 | Tue Mar 3 | vsMarquette | W69-68 | 15-15 | .500 | - | FS1 | Wintrust Arena · Chicago, IL |
| 31 | Sat Mar 7 | atProvidence | L55-93 | 15-16 | .484 | - | FS1 | Amica Mutual Pavilion · Providence, RI |
| 32 | Wed Mar 11 | atXavier | W71-67 | 16-16 | .500 | - | FS1 | Cintas Center · Cincinnati, OH |
