| 1 | Mon Nov 7 | vs AR-Pine Bluff | W73-72 | 1-0 | 1.000 | #14 | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 2 | Fri Nov 11 | vs Lamar | W77-66 | 2-0 | 1.000 | #14 | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 3 | Mon Nov 14 | vs N'Western St | L63-64 | 2-1 | .667 | #15 | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 4 | Thu Nov 17 | vs UL Monroe | W95-60 | 3-1 | .750 | - | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 5 | Fri Nov 25 | vs California | W59-48 | 4-1 | .800 | - | CBS | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 6 | Sat Nov 26 | vs Iowa | W79-66 | 5-1 | .833 | - | CBS | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 7 | Wed Nov 30 | vs Providence | W75-62 | 6-1 | .857 | - | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 8 | Tue Dec 6 | vs Jackson St | W78-51 | 7-1 | .875 | #24 | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 9 | Sat Dec 10 | at SMU | W83-75 | 8-1 | .889 | #24 | ESPN2 | Moody Coliseum · Dallas, TX |
| 10 | Sun Dec 18 | vs Miss Valley St | W88-43 | 9-1 | .900 | #21 | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 11 | Wed Dec 21 | at Utah | W75-71 | 10-1 | .909 | #20 | PACN | Jon M. Huntsman Center · Salt Lake City, UT |
| 12 | Wed Dec 28 | vs C Arkansas | W103-57 | 11-1 | .917 | #18 | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 13 | Sat Dec 31 | vs Texas Tech | W67-61 | 12-1 | .923 | #18 | ESPNU | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 14 | Wed Jan 4 | at #19Baylor | W88-87 | 13-1 | .929 | #17 | ESPN2 | Ferrell Center · Waco, TX |
| 15 | Sat Jan 7 | vs #25Iowa State | L67-69 | 13-2 | .867 | #17 | ESPNU | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 16 | Wed Jan 11 | at #10Texas | L75-79 | 13-3 | .813 | #17 | ESPN2 | Moody Center · Austin, TX |
| 17 | Sat Jan 14 | vs #11Kansas St | W82-68 | 14-3 | .824 | #17 | ESPN2 | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 18 | Wed Jan 18 | at West Virginia | L65-74 | 14-4 | .778 | #14 | | WVU Coliseum · Morgantown, WV |
| 19 | Sat Jan 21 | at #2Kansas | W83-60 | 15-4 | .789 | #14 | CBS | Allen Fieldhouse · Lawrence, KS |
| 20 | Tue Jan 24 | vs Oklahoma | W79-52 | 16-4 | .800 | #11 | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 21 | Sat Jan 28 | at Mississippi St | L74-81 (OT) | 16-5 | .762 | - | ESPN2 | Humphrey Coliseum · Starkville, MS |
| 22 | Tue Jan 31 | vsWest Virginia | W76-72 | 17-5 | .773 | #15 | ESPNU | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 23 | Sat Feb 4 | at Oklahoma St | L73-79 | 17-6 | .739 | #15 | | Gallagher-Iba Arena · Stillwater, OK |
| 24 | Tue Feb 7 | at#12Kansas St | L61-82 | 17-7 | .708 | #17 | ESPNU | Bramlage Coliseum · Manhattan, KS |
| 25 | Sat Feb 11 | vs#14Baylor | L68-72 | 17-8 | .680 | #17 | ESPN2 | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 26 | Wed Feb 15 | at#19Iowa State | L59-70 | 17-9 | .654 | #22 | ESPNU | James H. Hilton Coliseum · Ames, IA |
| 27 | Sat Feb 18 | vsOklahoma St | W100-75 | 18-9 | .667 | #22 | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 28 | Mon Feb 20 | vs#3Kansas | L58-63 | 18-10 | .643 | #24 | ESPN | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 29 | Sat Feb 25 | atTexas Tech | W83-82 | 19-10 | .655 | #24 | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 30 | Wed Mar 1 | vs#9Texas | W75-73 | 20-10 | .667 | #22 | ESPN2 | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 31 | Sat Mar 4 | atOklahoma | L60-74 | 20-11 | .645 | #22 | | Lloyd Noble Center · Norman, OK |
| 32 | Thu Mar 9 | atKansas St | W80-67 | 21-11 | .656 | - | ESPN2 | Bramlage Coliseum · Manhattan, KS |
| 33 | Fri Mar 10 | atTexas | L60-66 | 21-12 | .636 | - | ESPN | Moody Center · Austin, TX |
| 34 | Fri Mar 17 | vs #11Arizona St | W72-70 | 22-12 | .647 | #6 | truTV | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 35 | Sun Mar 19 | at #3Gonzaga | L81-84 | 22-13 | .629 | #6 | TBS | McCarthey Athletic Center · Spokane, WA |
