| 1 | Thu Nov 7 | vs TBD | W83-62 | 1-0 | 1.000 | - | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 2 | Tue Nov 12 | vsLouisiana | W98-65 | 2-0 | 1.000 | - | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 3 | Mon Nov 18 | vsAir Force | W65-54 | 3-0 | 1.000 | - | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 4 | Thu Nov 21 | vsUC Irvine | W59-58 | 4-0 | 1.000 | - | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 5 | Sun Nov 24 | atClemson | L60-62 (OT) | 4-1 | .800 | - | ESPN2 | T-Mobile Arena · Las Vegas, NV |
| 6 | Tue Nov 26 | atWyoming | W64-47 | 5-1 | .833 | - | | T-Mobile Arena · Las Vegas, NV |
| 7 | Tue Dec 3 | vsIllinois St | W81-69 | 6-1 | .857 | - | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 8 | Fri Dec 6 | vsUSC | L78-80 | 6-2 | .750 | - | ESPN2 | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 9 | Wed Dec 11 | vsWinthrop | W70-60 | 7-2 | .778 | - | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 10 | Sat Dec 14 | vsLamar | W79-50 | 8-2 | .800 | - | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 11 | Sun Dec 22 | vsXavier | L59-67 | 8-3 | .727 | - | ESPN2 | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 12 | Mon Dec 30 | vsGeorge Mason | W87-53 | 9-3 | .750 | - | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 13 | Sat Jan 4 | vsIowa State | W81-79 (OT) | 10-3 | .769 | - | ESPNU | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 14 | Tue Jan 7 | atKansas St | W59-57 | 11-3 | .786 | - | ESPNU | Bramlage Coliseum · Manhattan, KS |
| 15 | Sat Jan 11 | vsOklahoma St | W52-40 | 12-3 | .800 | - | ESPN2 | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 16 | Tue Jan 14 | at#12West Virginia | L49-81 | 12-4 | .750 | - | ESPNU | WVU Coliseum · Morgantown, WV |
| 17 | Sat Jan 18 | atOklahoma | L63-83 | 12-5 | .706 | - | | Lloyd Noble Center · Norman, OK |
| 18 | Tue Jan 21 | vs#18Texas Tech | W65-54 | 13-5 | .722 | - | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 19 | Sat Jan 25 | atArkansas | L67-78 | 13-6 | .684 | - | ESPN2 | Bud Walton Arena · Fayetteville, AR |
| 20 | Wed Jan 29 | vsTexas | L61-62 | 13-7 | .650 | - | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 21 | Sat Feb 1 | at#1Baylor | L52-68 | 13-8 | .619 | - | ESPN2 | Ferrell Center · Waco, TX |
| 22 | Wed Feb 5 | atOklahoma St | L57-72 | 13-9 | .591 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 23 | Sat Feb 8 | vs#3Kansas | L46-60 | 13-10 | .565 | - | ESPN2 | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 24 | Mon Feb 10 | at#24Texas Tech | L42-88 | 13-11 | .542 | - | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 25 | Sat Feb 15 | vsKansas St | W68-57 | 14-11 | .560 | - | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 26 | Wed Feb 19 | atTexas | L56-70 | 14-12 | .538 | - | LHN | Moody Center · Austin, TX |
| 27 | Sat Feb 22 | vs#17West Virginia | W67-60 (OT) | 15-12 | .556 | - | ESPNU | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 28 | Tue Feb 25 | atIowa State | L59-65 | 15-13 | .536 | - | ESPNU | James H. Hilton Coliseum · Ames, IA |
| 29 | Sat Feb 29 | vs#2Baylor | W75-72 | 16-13 | .552 | - | ESPN | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 30 | Wed Mar 4 | at#1Kansas | L66-75 | 16-14 | .533 | - | | Allen Fieldhouse · Lawrence, KS |
| 31 | Sat Mar 7 | vsOklahoma | L76-78 | 16-15 | .516 | - | ESPN2 | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 32 | Wed Mar 11 | vsKansas St | L49-53 | 16-16 | .500 | - | ESPNU | Ed and Rae Schollmaier Arena · Fort Worth, TX |
