| 1 | Wed Nov 25 | vs Hou Christian | W69-45 | 1-0 | 1.000 | - | | Schollmaier Arena · Fort Worth, TX |
| 2 | Sat Nov 28 | vsTulsa | W70-65 | 2-0 | 1.000 | - | | T-Mobile Center · Kansas City, MOS |
| 3 | Sun Nov 29 | vsLiberty | W56-52 | 3-0 | 1.000 | - | ESPN2 | T-Mobile Center · Kansas City, MOS |
| 4 | Thu Dec 3 | vsN'Western St | W74-68 | 4-0 | 1.000 | - | | Schollmaier Arena · Fort Worth, TX |
| 5 | Sun Dec 6 | vsOklahoma | L78-82 | 4-1 | .800 | - | ESPN2 | Schollmaier Arena · Fort Worth, TX |
| 6 | Wed Dec 9 | vsProvidence | L70-79 | 4-2 | .667 | - | ESPNU | Schollmaier Arena · Fort Worth, TX |
| 7 | Sat Dec 12 | vsTexas A&M | W73-55 | 5-2 | .714 | - | | Schollmaier Arena · Fort Worth, TX |
| 8 | Wed Dec 16 | atOklahoma St | W77-76 | 6-2 | .750 | - | ESPN | Gallagher-Iba Arena · Stillwater, OK |
| 9 | Tue Dec 22 | vsN Dakota St | W89-82 | 7-2 | .778 | - | ESPNU | Schollmaier Arena · Fort Worth, TX |
| 10 | Wed Dec 30 | vsPrairie View | W66-61 | 8-2 | .800 | - | | Schollmaier Arena · Fort Worth, TX |
| 11 | Sat Jan 2 | atKansas St | W67-60 | 9-2 | .818 | - | ESPNU | Bramlage Coliseum · Manhattan, KS |
| 12 | Tue Jan 5 | vs6Kansas | L64-93 | 9-3 | .750 | - | ESPN | Schollmaier Arena · Fort Worth, TX |
| 13 | Sat Jan 9 | vs2Baylor | L49-67 | 9-4 | .692 | - | ESPN | Schollmaier Arena · Fort Worth, TX |
| 14 | Tue Jan 12 | atOklahoma | L46-82 | 9-5 | .643 | - | | Lloyd Noble Center · Norman, OK |
| 15 | Sat Jan 16 | at13West Virginia | PPD | 12-14 | .462 | - | | WVU Coliseum · Morgantown, WV |
| 17 | Sat Jan 23 | vs5Texas | PPD | 12-14 | .462 | - | ESPN2 | Schollmaier Arena · Fort Worth, TX |
| 18 | Thu Jan 28 | at15Kansas | L51-59 | 9-6 | .600 | - | | Allen Fieldhouse · Lawrence, KS |
| 19 | Sat Jan 30 | atMissouri | L98-102 (OT) | 9-7 | .563 | - | ESPNU | Mizzou Arena · Columbia, MO |
| 20 | Wed Feb 3 | vsOklahoma St | W81-78 | 10-7 | .588 | - | ESPN2 | Schollmaier Arena · Fort Worth, TX |
| 22 | Tue Feb 9 | vsIowa State | W79-76 | 11-7 | .611 | - | ESPNU | Schollmaier Arena · Fort Worth, TX |
| 23 | Sat Feb 13 | at13Texas | L55-70 | 11-8 | .579 | - | LHN | Moody Center · Austin, TX |
| 24 | Tue Feb 16 | at15Texas Tech | PPD | 12-14 | .462 | - | | United Supermarkets Arena · Lubbock, TX |
| 26 | Sat Feb 20 | vsKansas St | L54-62 | 11-9 | .550 | - | | Schollmaier Arena · Fort Worth, TX |
| 27 | Tue Feb 23 | vs10West Virginia | L66-74 | 11-10 | .524 | - | ESPN2 | Schollmaier Arena · Fort Worth, TX |
| 28 | Sat Feb 27 | atIowa State | W76-72 | 12-10 | .545 | - | ESPNU | James H. Hilton Coliseum · Ames, IA |
| 29 | Tue Mar 2 | at18Texas Tech | L49-69 | 12-11 | .522 | - | | United Supermarkets Arena · Lubbock, TX |
| 30 | Thu Mar 4 | at6West Virginia | L67-76 | 12-12 | .500 | - | | WVU Coliseum · Morgantown, WV |
| 31 | Sun Mar 7 | vs15Texas | L64-76 | 12-13 | .480 | - | | Schollmaier Arena · Fort Worth, TX |
| 32 | Wed Mar 10 | vsKansas St | L50-71 | 12-14 | .462 | - | ESPN | T-Mobile Center · Kansas City, MOS |
