| 1 | Wed Nov 25 | vs Lamar | W89-45 | 1-0 | 1.000 | #17 | | Fertitta Center · Houston, TX |
| 2 | Fri Nov 27 | vs Boise St | W68-58 | 2-0 | 1.000 | - | | Fertitta Center · Houston, TX |
| 3 | Sun Nov 29 | vs Texas Tech | W64-53 | 3-0 | 1.000 | - | ESPN2 | Fertitta Center · Houston, TX |
| 4 | Sat Dec 5 | vs South Carolina | W77-67 | 4-0 | 1.000 | #10 | | Fertitta Center · Houston, TX |
| 7 | Tue Dec 15 | vs UCF | PPD | 28-4 | .875 | #6 | ESPN2 | Fertitta Center · Houston, TX |
| 8 | Sun Dec 20 | vs Alcorn St | W88-55 | 5-0 | 1.000 | #6 | | Fertitta Center · Houston, TX |
| 9 | Tue Dec 22 | vs Temple | W76-50 | 6-0 | 1.000 | #6 | | Fertitta Center · Houston, TX |
| 10 | Sat Dec 26 | atUCF | W63-54 | 7-0 | 1.000 | #6 | ABC | Addition Financial Arena · Orlando, FL |
| 11 | Tue Dec 29 | at Tulsa | L64-65 | 7-1 | .875 | #5 | ESPN2 | Donald W. Reynolds Center · Tulsa, OK |
| 12 | Sun Jan 3 | at SMU | W74-60 | 8-1 | .889 | #5 | ESPN2 | Moody Coliseum · Dallas, TX |
| 13 | Wed Jan 6 | vs Wichita St | W70-63 | 9-1 | .900 | #11 | | Fertitta Center · Houston, TX |
| 14 | Sat Jan 9 | vs Tulane | W71-50 | 10-1 | .909 | #11 | ESPNU | Fertitta Center · Houston, TX |
| 15 | Thu Jan 14 | at South Florida | PPD | 28-4 | .875 | #11 | | Yuengling Center · Tampa, FL |
| 16 | Sun Jan 17 | vsUCF | W75-58 | 11-1 | .917 | #11 | ESPNU | Fertitta Center · Houston, TX |
| 17 | Wed Jan 20 | vsTulsa | W86-59 | 12-1 | .923 | #8 | | Fertitta Center · Houston, TX |
| 18 | Sat Jan 23 | atTemple | W68-51 | 13-1 | .929 | #8 | CBS | Liacouras Center · Philadelphia, PA |
| 19 | Thu Jan 28 | atTulane | W83-60 | 14-1 | .933 | #6 | ESPN | Devlin Fieldhouse · New Orleans, LA |
| 20 | Sun Jan 31 | vsSMU | W70-48 | 15-1 | .938 | #6 | ESPN | Fertitta Center · Houston, TX |
| 21 | Wed Feb 3 | at E Carolina | L73-82 | 15-2 | .882 | #5 | | Williams Arena at Minges Coliseum · Greenville, NC |
| 22 | Sat Feb 6 | vs TBD | W112-46 | 16-2 | .889 | #5 | | Fertitta Center · Houston, TX |
| 23 | Wed Feb 10 | atSouth Florida | W82-65 | 17-2 | .895 | #8 | ESPNU | Yuengling Center · Tampa, FL |
| 24 | Sun Feb 14 | vs Memphis | PPD | 28-4 | .875 | #8 | | Fertitta Center · Houston, TX |
| 26 | Thu Feb 18 | atWichita St | L63-68 | 17-3 | .850 | #6 | ESPN2 | Charles Koch Arena · Wichita, KS |
| 27 | Sun Feb 21 | vs Cincinnati | W90-52 | 18-3 | .857 | #6 | ESPN | Fertitta Center · Houston, TX |
| 28 | Thu Feb 25 | vs Western KY | W81-57 | 19-3 | .864 | #12 | ESPN2 | Fertitta Center · Houston, TX |
| 29 | Sun Feb 28 | vsSouth Florida | W98-52 | 20-3 | .870 | #12 | ESPNU | Fertitta Center · Houston, TX |
| 30 | Sun Mar 7 | vsMemphis | W67-64 | 21-3 | .875 | #9 | CBS | Fertitta Center · Houston, TX |
| 31 | Fri Mar 12 | vsTulane | W77-52 | 22-3 | .880 | - | ESPN2 | Fertitta Center · Houston, TX |
| 32 | Sat Mar 13 | vsMemphis | W76-74 | 23-3 | .885 | - | ESPN2 | Fertitta Center · Houston, TX |
| 33 | Sun Mar 14 | vsCincinnati | W91-54 | 24-3 | .889 | - | ESPN | Fertitta Center · Houston, TX |
| 34 | Fri Mar 19 | vs #15Cleveland St | W87-56 | 25-3 | .893 | #2 | truTV | Fertitta Center · Houston, TX |
| 35 | Sun Mar 21 | vs #10Rutgers | W63-60 | 26-3 | .897 | #2 | TBS | Fertitta Center · Houston, TX |
| 36 | Sat Mar 27 | vs #11Syracuse | W62-46 | 27-3 | .900 | #2 | TBS | Fertitta Center · Houston, TX |
| 37 | Mon Mar 29 | vs #12Oregon St | W67-61 | 28-3 | .903 | #2 | CBS | Fertitta Center · Houston, TX |
| 38 | Sat Apr 3 | at #1Baylor | L59-78 | 28-4 | .875 | #2 | CBS | Ferrell Center · Waco, TX |
Sam Houston
Rice