| 1 | Tue Nov 9 | vs Hofstra | W83-75 (OT) | 1-0 | 1.000 | #15 | | Fertitta Center · Houston, TX |
| 2 | Fri Nov 12 | vsRice | W79-46 | 2-0 | 1.000 | #15 | | Fertitta Center · Houston, TX |
| 3 | Tue Nov 16 | vsVirginia | W67-47 | 3-0 | 1.000 | #15 | ESPN | Fertitta Center · Houston, TX |
| 4 | Mon Nov 22 | vsButler | W70-52 | 4-0 | 1.000 | - | ESPN2 | Fertitta Center · Houston, TX |
| 5 | Tue Nov 23 | vsWisconsin | L63-65 | 4-1 | .800 | - | ESPN | Fertitta Center · Houston, TX |
| 6 | Wed Nov 24 | atOregon | W78-49 | 5-1 | .833 | - | ESPN2 | Matthew Knight Arena · Eugene, OR |
| 7 | Tue Nov 30 | vsN'Western St | W99-58 | 6-1 | .857 | #15 | | Fertitta Center · Houston, TX |
| 8 | Fri Dec 3 | vsBryant | W111-44 | 7-1 | .875 | #15 | | Fertitta Center · Houston, TX |
| 9 | Mon Dec 6 | vsAlcorn St | W77-45 | 8-1 | .889 | #14 | | Fertitta Center · Houston, TX |
| 10 | Sat Dec 11 | at#9Alabama | L82-83 | 8-2 | .800 | #14 | ESPN2 | Coleman Coliseum · Tuscaloosa, AL |
| 11 | Tue Dec 14 | vsLouisiana | W71-56 | 9-2 | .818 | #14 | | Fertitta Center · Houston, TX |
| 12 | Sat Dec 18 | vsOklahoma St | W72-61 | 10-2 | .833 | #14 | ESPNU | Fertitta Center · Houston, TX |
| 13 | Wed Dec 22 | vsTexas St | W80-47 | 11-2 | .846 | #13 | | Fertitta Center · Houston, TX |
| 14 | Tue Dec 28 | vsCincinnati | PPD | 11-2 | .846 | #12 | | Fertitta Center · Houston, TX |
| 15 | Sun Jan 2 | atTemple | W66-61 | 12-2 | .857 | #12 | ESPN | Liacouras Center · Philadelphia, PA |
| 16 | Wed Jan 5 | atSouth Florida | W83-66 | 13-2 | .867 | #12 | | Yuengling Center · Tampa, FL |
| 17 | Sat Jan 8 | vsWichita St | W76-66 | 14-2 | .875 | #12 | CBS | Fertitta Center · Houston, TX |
| 18 | Sat Jan 15 | atTulsa | W66-64 | 15-2 | .882 | #11 | ESPN2 | Donald W. Reynolds Center · Tulsa, OK |
| 19 | Tue Jan 18 | vsSouth Florida | W74-55 | 16-2 | .889 | #10 | | Fertitta Center · Houston, TX |
| 20 | Sat Jan 22 | vsE Carolina | W79-36 | 17-2 | .895 | #10 | | Fertitta Center · Houston, TX |
| 21 | Sat Jan 29 | atUCF | W63-49 | 18-2 | .900 | #7 | ESPN2 | Addition Financial Arena · Orlando, FL |
| 22 | Wed Feb 2 | vsTulane | W73-62 | 19-2 | .905 | #6 | | Fertitta Center · Houston, TX |
| 23 | Sun Feb 6 | atCincinnati | W80-58 | 20-2 | .909 | #6 | ESPN2 | Fifth Third Arena · Cincinnati, OH |
| 24 | Wed Feb 9 | atSMU | L83-85 | 20-3 | .870 | #6 | ESPN2 | Moody Coliseum · Dallas, TX |
| 25 | Sat Feb 12 | vsMemphis | L59-69 | 20-4 | .833 | #6 | ABC | Fertitta Center · Houston, TX |
| 26 | Thu Feb 17 | vsUCF | W70-52 | 21-4 | .840 | #14 | ESPN2 | Fertitta Center · Houston, TX |
| 27 | Sun Feb 20 | atWichita St | W76-74 (2OT) | 22-4 | .846 | #14 | ESPN | Charles Koch Arena · Wichita, KS |
| 28 | Wed Feb 23 | atTulane | W81-67 | 23-4 | .852 | #14 | | Devlin Fieldhouse · New Orleans, LA |
| 29 | Sun Feb 27 | vsSMU | W75-61 | 24-4 | .857 | #14 | ESPN | Fertitta Center · Houston, TX |
| 30 | Tue Mar 1 | vsCincinnati | W71-53 | 25-4 | .862 | #14 | ESPNU | Fertitta Center · Houston, TX |
| 31 | Thu Mar 3 | vsTemple | W84-46 | 26-4 | .867 | #14 | ESPN2 | Fertitta Center · Houston, TX |
| 32 | Sun Mar 6 | atMemphis | L61-75 | 26-5 | .839 | #14 | CBS | FedExForum · Memphis, TN |
| 33 | Fri Mar 11 | vsCincinnati | W69-56 | 27-5 | .844 | - | ESPN2 | Fertitta Center · Houston, TX |
| 34 | Sat Mar 12 | vsTulane | W86-66 | 28-5 | .848 | - | ESPN2 | Fertitta Center · Houston, TX |
| 35 | Sun Mar 13 | vsMemphis | W71-53 | 29-5 | .853 | - | ESPN | Fertitta Center · Houston, TX |
| 36 | Fri Mar 18 | vs#12UAB | W82-68 | 30-5 | .857 | #5 | TNT | Fertitta Center · Houston, TX |
| 37 | Sun Mar 20 | at#4Illinois | W68-53 | 31-5 | .861 | #5 | CBS | State Farm Center · Champaign, IL |
| 38 | Thu Mar 24 | at#1Arizona | W72-60 | 32-5 | .865 | #5 | TBS | McKale Center · Tucson, AZ |
| 39 | Sat Mar 26 | at#2Villanova | L44-50 | 32-6 | .842 | #5 | TBS | Finneran Pavilion · Villanova, PA |
