| 1 | Mon Nov 6 | vs UL Monroe | W84-31 | 1-0 | 1.000 | #7 | | Fertitta Center · Houston, TX |
| 2 | Sat Nov 11 | vsTexas A&M-CC | W82-50 | 2-0 | 1.000 | #7 | | Fertitta Center · Houston, TX |
| 3 | Mon Nov 13 | vsStetson | W79-48 | 3-0 | 1.000 | #6 | | Fertitta Center · Houston, TX |
| 4 | Thu Nov 16 | atTowson | W65-49 | 4-0 | 1.000 | #6 | ESPN2 | TD Arena · Charleston, SC |
| 5 | Fri Nov 17 | atUtah | W76-66 | 5-0 | 1.000 | #6 | ESPN2 | TD Arena · Charleston, SC |
| 6 | Sun Nov 19 | vsDayton | W69-55 | 6-0 | 1.000 | #6 | ESPN | TD Arena · Charleston, SC |
| 7 | Fri Nov 24 | vsMontana | W79-44 | 7-0 | 1.000 | #6 | | Fertitta Center · Houston, TX |
| 8 | Fri Dec 1 | atXavier | W66-60 | 8-0 | 1.000 | #6 | FS1 | Cintas Center · Cincinnati, OH |
| 9 | Wed Dec 6 | vsRice | W75-39 | 9-0 | 1.000 | #3 | | Fertitta Center · Houston, TX |
| 10 | Sat Dec 9 | vsJackson St | W89-55 | 10-0 | 1.000 | #3 | | Fertitta Center · Houston, TX |
| 11 | Sat Dec 16 | vsTexas A&M | W70-66 | 11-0 | 1.000 | #4 | ESPN2 | Toyota Center · Houston, TX |
| 12 | Thu Dec 21 | vsTexas St | W72-37 | 12-0 | 1.000 | #3 | | Fertitta Center · Houston, TX |
| 13 | Sat Dec 30 | vsPenn | W81-42 | 13-0 | 1.000 | #3 | | Fertitta Center · Houston, TX |
| 14 | Sat Jan 6 | vsWest Virginia | W89-55 | 14-0 | 1.000 | #3 | | Fertitta Center · Houston, TX |
| 15 | Tue Jan 9 | atIowa State | L53-57 | 14-1 | .933 | #2 | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 16 | Sat Jan 13 | atTCU | L67-68 | 14-2 | .875 | #2 | ESPN | Schollmaier Arena · Fort Worth, TX |
| 17 | Wed Jan 17 | vs25Texas Tech | W77-54 | 15-2 | .882 | #5 | ESPNU | Fertitta Center · Houston, TX |
| 18 | Sat Jan 20 | vsUCF | W57-42 | 16-2 | .889 | #5 | | Fertitta Center · Houston, TX |
| 19 | Tue Jan 23 | at21BYU | W75-68 | 17-2 | .895 | #4 | | Marriott Center · Provo, UT |
| 20 | Sat Jan 27 | vsKansas St | W74-52 | 18-2 | .900 | #4 | ESPN | Fertitta Center · Houston, TX |
| 21 | Mon Jan 29 | atTexas | W76-72 (OT) | 19-2 | .905 | #4 | ESPN | Moody Center · Austin, TX |
| 22 | Sat Feb 3 | at8Kansas | L65-78 | 19-3 | .864 | #4 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 23 | Tue Feb 6 | vsOklahoma St | W79-63 | 20-3 | .870 | #5 | ESPN2 | Fertitta Center · Houston, TX |
| 24 | Sat Feb 10 | atCincinnati | W67-62 | 21-3 | .875 | #5 | ESPN2 | Fifth Third Arena · Cincinnati, OH |
| 25 | Sat Feb 17 | vsTexas | W82-61 | 22-3 | .880 | #3 | CBS | Fertitta Center · Houston, TX |
| 26 | Mon Feb 19 | vs6Iowa State | W73-65 | 23-3 | .885 | #2 | ESPN | Fertitta Center · Houston, TX |
| 27 | Sat Feb 24 | at11Baylor | W82-76 (OT) | 24-3 | .889 | #2 | CBS | Ferrell Center · Waco, TX |
| 28 | Tue Feb 27 | vsCincinnati | W67-59 | 25-3 | .893 | #1 | ESPN2 | Fertitta Center · Houston, TX |
| 29 | Sat Mar 2 | atOklahoma | W87-85 | 26-3 | .897 | #1 | ESPN2 | Lloyd Noble Center · Norman, OK |
| 30 | Wed Mar 6 | atUCF | W67-59 | 27-3 | .900 | #1 | | Addition Financial Arena · Orlando, FL |
| 31 | Sat Mar 9 | vs14Kansas | W76-46 | 28-3 | .903 | #1 | ESPN | Fertitta Center · Houston, TX |
| 32 | Thu Mar 14 | vsTCU | W60-45 | 29-3 | .906 | #1 | ESPN | T-Mobile Center · Kansas City, MOS |
| 33 | Fri Mar 15 | vs25Texas Tech | W82-59 | 30-3 | .909 | #1 | ESPN2 | T-Mobile Center · Kansas City, MOS |
| 34 | Sat Mar 16 | vs7Iowa State | L41-69 | 30-4 | .882 | #1 | ESPN | T-Mobile Center · Kansas City, MOS |
| 35 | Fri Mar 22 | vs16Longwood | W86-46 | 31-4 | .886 | #1 | TNT | FedExForum · Memphis, TN |
| 36 | Sun Mar 24 | vs9Texas A&M | W100-95 (OT) | 32-4 | .889 | #1 | TNT | FedExForum · Memphis, TN |
| 37 | Fri Mar 29 | vs4Duke | L51-54 | 32-5 | .865 | #1 | CBS | Fertitta Center · Houston, TX |
