| 1 | Wed Nov 25 | at UT Arlington | W75-68 | 1-0 | 1.000 | - | ESPN | College Park Center · Arlington, TX |
| 2 | Sat Nov 28 | vsTexas So | W85-65 | 2-0 | 1.000 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 3 | Tue Dec 1 | atMarquette | W70-62 | 3-0 | 1.000 | - | | Fiserv Forum · Milwaukee, WI |
| 4 | Sat Dec 5 | vsOakland | W84-71 | 4-0 | 1.000 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 5 | Tue Dec 8 | vsOral Roberts | W83-78 | 5-0 | 1.000 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 6 | Sat Dec 12 | atWichita St | W67-64 | 6-0 | 1.000 | - | | Charles Koch Arena · Wichita, KS |
| 7 | Wed Dec 16 | vsTCU | L76-77 | 6-1 | .857 | - | ESPN | Gallagher-Iba Arena · Stillwater, OK |
| 8 | Sun Dec 20 | at#11Texas | L74-77 | 6-2 | .750 | - | LHN | Moody Center · Austin, TX |
| 9 | Sat Jan 2 | at#13Texas Tech | W82-77 (OT) | 7-2 | .778 | - | | United Supermarkets Arena · Lubbock, TX |
| 10 | Mon Jan 4 | vs#14West Virginia | L84-87 | 7-3 | .700 | - | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 11 | Sat Jan 9 | atKansas St | W70-54 | 8-3 | .727 | - | ESPN2 | Bramlage Coliseum · Manhattan, KS |
| 12 | Tue Jan 12 | vs#6Kansas | W75-70 | 9-3 | .750 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 13 | Sat Jan 16 | vsOklahoma | PPD | 21-9 | .700 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 14 | Tue Jan 19 | at#14West Virginia | PPD | 21-9 | .700 | - | | WVU Coliseum · Morgantown, WV |
| 15 | Sat Jan 23 | vs#2Baylor | L66-81 | 9-4 | .692 | - | CBS | Gallagher-Iba Arena · Stillwater, OK |
| 16 | Mon Jan 25 | atIowa State | W81-60 | 10-4 | .714 | - | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 17 | Sat Jan 30 | vsArkansas | W81-77 | 11-4 | .733 | - | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 18 | Wed Feb 3 | atTCU | L78-81 | 11-5 | .688 | - | ESPN2 | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 19 | Sat Feb 6 | vs#6Texas | W75-67 (2OT) | 12-5 | .706 | - | ABC | Gallagher-Iba Arena · Stillwater, OK |
| 20 | Mon Feb 8 | atKansas | L66-78 | 12-6 | .667 | #23 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 21 | Sat Feb 13 | vsKansas St | W67-60 | 13-6 | .684 | #23 | ESPNU | Gallagher-Iba Arena · Stillwater, OK |
| 22 | Tue Feb 16 | vsIowa State | W76-58 | 14-6 | .700 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 23 | Sat Feb 20 | at#2Baylor | PPD | 21-9 | .700 | - | | Ferrell Center · Waco, TX |
| 24 | Mon Feb 22 | vs#18Texas Tech | W74-69 (OT) | 15-6 | .714 | - | ESPN | Gallagher-Iba Arena · Stillwater, OK |
| 25 | Sat Feb 27 | at#7Oklahoma | W94-90 (OT) | 16-6 | .727 | - | ABC | Lloyd Noble Center · Norman, OK |
| 26 | Mon Mar 1 | vs#16Oklahoma | W79-75 | 17-6 | .739 | #17 | ESPN | Gallagher-Iba Arena · Stillwater, OK |
| 27 | Thu Mar 4 | at#3Baylor | L70-81 | 17-7 | .708 | #17 | ESPN2 | Ferrell Center · Waco, TX |
| 28 | Sat Mar 6 | at#6West Virginia | W85-80 | 18-7 | .720 | #17 | ESPN2 | WVU Coliseum · Morgantown, WV |
| 29 | Thu Mar 11 | atWest Virginia | W72-69 | 19-7 | .731 | - | ESPN | WVU Coliseum · Morgantown, WV |
| 30 | Fri Mar 12 | atBaylor | W83-74 | 20-7 | .741 | - | ESPN | Ferrell Center · Waco, TX |
| 31 | Sat Mar 13 | atTexas | L86-91 | 20-8 | .714 | - | ESPN | Moody Center · Austin, TX |
| 32 | Fri Mar 19 | vs#13Liberty | W69-60 | 21-8 | .724 | #4 | TBS | Gallagher-Iba Arena · Stillwater, OK |
| 33 | Sun Mar 21 | vs#12Oregon St | L70-80 | 21-9 | .700 | #4 | TBS | Gallagher-Iba Arena · Stillwater, OK |
