| 1 | Tue Nov 4 | vs Oral Roberts | 8:00 PM | 7-23 | .233 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 2 | Sun Nov 9 | vsTexas A&M | 2:00 PM | 23-11 | .676 | - | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 3 | Wed Nov 12 | vsPrairie View | 8:00 PM | 5-27 | .156 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 4 | Sun Nov 16 | vsTexas A&M-CC | 2:00 PM | 20-14 | .588 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 5 | Wed Nov 19 | vsSouth Florida | 8:00 PM | 13-19 | .406 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 6 | Sat Nov 22 | vsNicholls | 3:00 PM | 20-13 | .606 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 7 | Thu Nov 27 | atNorthwestern | 10:30 PM | 17-16 | .515 | - | Peacock | Welsh-Ryan Arena · Evanston, IL |
| 8 | Tue Dec 2 | vsSam Houston | 8:00 PM | 13-19 | .406 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 9 | Sat Dec 6 | atGrand Canyon | 7:30 PM | 26-8 | .765 | - | CBS | GCU Arena · Phoenix, AZ |
| 10 | Sat Dec 13 | atOklahoma | 1:00 PM | 20-14 | .588 | - | FOX | Lloyd Noble Center · Norman, OK |
| 11 | Thu Dec 18 | vsKansas City | 8:00 PM | 13-20 | .394 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 12 | Sun Dec 21 | vsFullerton | 2:00 PM | 6-26 | .188 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 13 | Mon Dec 29 | vsBethune | 8:00 PM | 17-16 | .515 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 14 | Sat Jan 3 | at#10Texas Tech | 1:00 PM | 28-9 | .757 | - | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 15 | Tue Jan 6 | vsUCF | 8:00 PM | 20-17 | .541 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 16 | Sat Jan 10 | at#16Iowa State | 4:00 PM | 25-10 | .714 | - | | James H. Hilton Coliseum · Ames, IA |
| 17 | Tue Jan 13 | vsBaylor | 9:00 PM | 20-15 | .571 | - | CBS | Gallagher-Iba Arena · Stillwater, OK |
| 18 | Sat Jan 17 | vsKansas St | 10:00 PM | 16-17 | .485 | - | CBS | Gallagher-Iba Arena · Stillwater, OK |
| 19 | Tue Jan 20 | atTCU | 8:00 PM | 16-16 | .500 | - | ESPN+ | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 20 | Sat Jan 24 | vs#16Iowa State | 4:00 PM | 25-10 | .714 | - | Peacock | Gallagher-Iba Arena · Stillwater, OK |
| 21 | Sat Jan 31 | atUtah | 2:00 PM | 16-17 | .485 | - | TNT | Jon M. Huntsman Center · Salt Lake City, UT |
| 22 | Wed Feb 4 | vs#8BYU | 9:00 PM | 26-10 | .722 | - | FS1 | Gallagher-Iba Arena · Stillwater, OK |
| 23 | Sat Feb 7 | at#13Arizona | 4:00 PM | 24-13 | .649 | - | | McKale Center · Tucson, AZ |
| 24 | Tue Feb 10 | atArizona St | 8:00 PM | 13-20 | .394 | - | CBS | Desert Financial Arena · Tempe, AZ |
| 25 | Sat Feb 14 | vsTCU | 12:00 PM | 16-16 | .500 | - | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 26 | Wed Feb 18 | vs#19Kansas | 9:00 PM | 21-13 | .618 | - | Peacock | Gallagher-Iba Arena · Stillwater, OK |
| 27 | Sat Feb 21 | atColorado | 3:30 PM | 14-21 | .400 | - | TNT | CU Events Center · Boulder, CO |
| 28 | Tue Feb 24 | vsWest Virginia | 7:00 PM | 19-13 | .594 | - | CBS | Gallagher-Iba Arena · Stillwater, OK |
| 29 | Sat Feb 28 | atCincinnati | 2:00 PM | 19-16 | .543 | - | CBS | Fifth Third Arena · Cincinnati, OH |
| 30 | Tue Mar 3 | atUCF | 7:00 PM | 20-17 | .541 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 31 | Sat Mar 7 | vs#2Houston | 12:00 PM | 35-5 | .875 | - | CBS | Gallagher-Iba Arena · Stillwater, OK |
