| 1 | Mon Nov 6 | vs Abilene Chrstn | L59-64 | 0-1 | .000 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 2 | Sun Nov 12 | vs Sam Houston | W85-70 | 1-1 | .500 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 3 | Thu Nov 16 | at St Bonaventure | L64-66 | 1-2 | .333 | - | ESPNU | Reilly Center · Saint Bonaventure, NY |
| 4 | Fri Nov 17 | vs Notre Dame | L64-66 (OT) | 1-3 | .250 | - | ESPNU | Gallagher-Iba Arena · Stillwater, OK |
| 5 | Mon Nov 20 | vs New Orleans | W96-68 | 2-3 | .400 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 6 | Fri Nov 24 | vs Hou Christian | W92-65 | 3-3 | .500 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 7 | Thu Nov 30 | vs #15Creighton | L65-79 | 3-4 | .429 | - | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 8 | Tue Dec 5 | at S Illinois | L68-70 | 3-5 | .375 | - | CBS | Banterra Center · Carbondale, IL |
| 9 | Sun Dec 10 | vs Tulsa | W72-57 | 4-5 | .444 | - | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 10 | Sun Dec 17 | vs Oral Roberts | W81-60 | 5-5 | .500 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 11 | Wed Dec 20 | vs Wofford | W76-70 | 6-5 | .545 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 12 | Sun Dec 31 | vs SC State | W86-70 | 7-5 | .583 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 13 | Wed Jan 3 | vs Chicago St | W72-53 | 8-5 | .615 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 14 | Sat Jan 6 | vs #18Baylor | L70-75 (OT) | 8-6 | .571 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 15 | Tue Jan 9 | at Texas Tech | L73-90 | 8-7 | .533 | - | | United Supermarkets Arena · Lubbock, TX |
| 16 | Sat Jan 13 | at Iowa State | L42-66 | 8-8 | .500 | - | | James H. Hilton Coliseum · Ames, IA |
| 17 | Tue Jan 16 | vs #3Kansas | L66-90 | 8-9 | .471 | - | ESPN | Gallagher-Iba Arena · Stillwater, OK |
| 18 | Sat Jan 20 | at Kansas St | L66-70 | 8-10 | .444 | - | | Bramlage Coliseum · Manhattan, KS |
| 19 | Tue Jan 23 | vs TCU | L69-74 | 8-11 | .421 | - | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 20 | Sat Jan 27 | vs West Virginia | W70-66 | 9-11 | .450 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 21 | Tue Jan 30 | at#8Kansas | L54-83 | 9-12 | .429 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 22 | Sat Feb 3 | vsKansas St | W75-72 | 10-12 | .455 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 23 | Tue Feb 6 | at #5Houston | L63-79 | 10-13 | .435 | - | ESPN2 | Fertitta Center · Houston, TX |
| 24 | Sat Feb 10 | at Oklahoma | L62-66 | 10-14 | .417 | - | | Lloyd Noble Center · Norman, OK |
| 25 | Sat Feb 17 | vs #19BYU | W93-83 | 11-14 | .440 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 26 | Wed Feb 21 | at Cincinnati | W80-76 | 12-14 | .462 | - | | Fifth Third Arena · Cincinnati, OH |
| 27 | Sat Feb 24 | vsOklahoma | L82-84 (OT) | 12-15 | .444 | - | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 28 | Wed Feb 28 | vs UCF | L71-77 | 12-16 | .429 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 29 | Sat Mar 2 | at Texas | L65-81 | 12-17 | .414 | - | ESPN2 | Moody Center · Austin, TX |
| 30 | Tue Mar 5 | vsTexas Tech | L58-75 | 12-18 | .400 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 31 | Sat Mar 9 | at#20BYU | L71-85 | 12-19 | .387 | - | | Marriott Center · Provo, UT |
| 32 | Tue Mar 12 | atUCF | L62-77 | 12-20 | .375 | - | | Addition Financial Arena · Orlando, FL |
