| 1 | Tue Nov 9 | vs UT Arlington | W88-45 | 1-0 | 1.000 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 2 | Fri Nov 12 | vsOakland | L55-56 | 1-1 | .500 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 3 | Sun Nov 14 | vsPrairie View | W72-59 | 2-1 | .667 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 4 | Tue Nov 16 | vsUMass Lowell | W80-58 | 3-1 | .750 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 5 | Wed Nov 17 | atNC State | W74-68 | 4-1 | .800 | - | CBSSN | PNC Arena · Raleigh, NC |
| 6 | Mon Nov 22 | vsCharleston | W96-66 | 5-1 | .833 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 7 | Fri Nov 26 | atOral Roberts | W78-77 (OT) | 6-1 | .857 | - | | Mabee Center · Tulsa, OK |
| 8 | Wed Dec 1 | vsWichita St | L51-60 | 6-2 | .750 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 9 | Sun Dec 5 | vsXavier | L71-77 | 6-3 | .667 | - | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 10 | Mon Dec 13 | vsCleveland St | W98-93 (OT) | 7-3 | .700 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 11 | Sat Dec 18 | at14Houston | L61-72 | 7-4 | .636 | - | ESPNU | Fertitta Center · Houston, TX |
| 13 | Sat Jan 1 | at25Texas Tech | PPD | 15-15 | .500 | - | | United Supermarkets Arena · Lubbock, TX |
| 14 | Tue Jan 4 | vs6Kansas | L63-74 | 7-5 | .583 | - | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 15 | Sat Jan 8 | vs14Texas | W64-51 | 8-5 | .615 | - | CBS | Gallagher-Iba Arena · Stillwater, OK |
| 16 | Tue Jan 11 | atWest Virginia | L60-70 | 8-6 | .571 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 17 | Thu Jan 13 | at19Texas Tech | L57-78 | 8-7 | .533 | - | | United Supermarkets Arena · Lubbock, TX |
| 18 | Sat Jan 15 | at1Baylor | W61-54 | 9-7 | .563 | - | ESPN | Ferrell Center · Waco, TX |
| 19 | Wed Jan 19 | vsTCU | W57-56 | 10-7 | .588 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 20 | Sat Jan 22 | at23Texas | L51-56 | 10-8 | .556 | - | ESPN2 | Moody Center · Austin, TX |
| 21 | Wed Jan 26 | vs23Iowa State | L81-84 (OT) | 10-9 | .526 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 22 | Sat Jan 29 | atFlorida | L72-81 | 10-10 | .500 | - | ESPN2 | O'Connell Center · Gainesville, FL |
| 23 | Wed Feb 2 | atKansas St | L68-71 | 10-11 | .476 | - | ESPNU | Bramlage Coliseum · Manhattan, KS |
| 24 | Sat Feb 5 | vsOklahoma | W64-55 | 11-11 | .500 | - | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 25 | Tue Feb 8 | atTCU | L73-77 | 11-12 | .478 | - | ESPNU | Schollmaier Arena · Fort Worth, TX |
| 26 | Sat Feb 12 | vsWest Virginia | W81-58 | 12-12 | .500 | - | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 27 | Mon Feb 14 | at6Kansas | L62-76 | 12-13 | .480 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 28 | Sat Feb 19 | vsKansas St | W82-79 (OT) | 13-13 | .500 | - | ESPNU | Gallagher-Iba Arena · Stillwater, OK |
| 29 | Mon Feb 21 | vs10Baylor | L64-66 (OT) | 13-14 | .481 | - | ESPN | Gallagher-Iba Arena · Stillwater, OK |
| 30 | Sat Feb 26 | atOklahoma | L62-66 (OT) | 13-15 | .464 | - | CBS | Lloyd Noble Center · Norman, OK |
| 31 | Wed Mar 2 | atIowa State | W53-36 | 14-15 | .483 | - | | James H. Hilton Coliseum · Ames, IA |
| 32 | Sat Mar 5 | vs12Texas Tech | W52-51 | 15-15 | .500 | - | | Gallagher-Iba Arena · Stillwater, OK |
